An innovative rhein-matrine cocrystal: Synthesis, characterization, formation mechanism and pharmacokinetic study

[1]  F. Acartürk,et al.  Electrospun orally disintegrating film formulation of telmisartan , 2021, Pharmaceutical development and technology.

[2]  R. Pi,et al.  A research update on the therapeutic potential of rhein and its derivatives. , 2021, European journal of pharmacology.

[3]  Ming-Rui Shen,et al.  Development of chromatographic technologies for the quality control of Traditional Chinese Medicine in the Chinese Pharmacopoeia , 2020, Journal of pharmaceutical analysis.

[4]  Yang Lu,et al.  Anti-inflammatory Effects and Mechanisms of Rhein, an Anthraquinone Compound, and Its Applications in Treating Arthritis: A Review , 2020, Natural Products and Bioprospecting.

[5]  R. Pi,et al.  Discovery of a novel rhein-SAHA hybrid as a multi-targeted anti-glioblastoma drug , 2019, Investigational New Drugs.

[6]  Pintong Huang,et al.  Kidney-targeted rhein-loaded liponanoparticles for diabetic nephropathy therapy via size control and enhancement of renal cellular uptake , 2019, Theranostics.

[7]  Leiting Pan,et al.  Rhein inhibits ATP-triggered inflammatory responses in rheumatoid rat fibroblast-like synoviocytes. , 2019, International immunopharmacology.

[8]  G. Walker,et al.  Pharmaceutical Cocrystal Drug Products: An Outlook on Product Development. , 2018, Trends in pharmacological sciences.

[9]  Chaofeng Mu,et al.  Low molecular weight chitosan-based conjugates for efficient Rhein oral delivery: synthesis, characterization, and pharmacokinetics , 2018, Drug development and industrial pharmacy.

[10]  Gavin Walker,et al.  Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications , 2018, Crystal Growth & Design.

[11]  Y. Kuk,et al.  Effects of different fractions of Rheum palmatum root extract and anthraquinone compounds on fungicidal, insecticidal, and herbicidal activities , 2018, Journal of Plant Diseases and Protection.

[12]  Dechuan Li,et al.  Preparation, characterization, and in vivo study of rhein solid lipid nanoparticles for oral delivery , 2017, Chemical biology & drug design.

[13]  Jianping Ma,et al.  Biodegradable nanoparticles for improved kidney bioavailability of rhein: preparation, characterization, plasma, and kidney pharmacokinetics , 2017, Drug development and industrial pharmacy.

[14]  B. Aungst,et al.  Optimizing Oral Bioavailability in Drug Discovery: An Overview of Design and Testing Strategies and Formulation Options. , 2017, Journal of pharmaceutical sciences.

[15]  Bo Yang,et al.  Synthesis, characterization and biological activity of Rhein-cyclodextrin conjugate , 2017 .

[16]  S. Garneau‐Tsodikova,et al.  Inhibition of glioma progression by a newly discovered CD38 inhibitor , 2015, International journal of cancer.

[17]  D. Grenier,et al.  The anthraquinone rhein exhibits synergistic antibacterial activity in association with metronidazole or natural compounds and attenuates virulence gene expression in Porphyromonas gingivalis. , 2015, Archives of oral biology.

[18]  T. Lu,et al.  Pharmaceutical Cocrystals of Ribavirin with Reduced Release Rates , 2014 .

[19]  Limin Shi,et al.  Baicalein-nicotinamide cocrystal with enhanced solubility, dissolution, and oral bioavailability. , 2014, Journal of pharmaceutical sciences.

[20]  Cheng Peng,et al.  Rhein exerts pro- and anti-inflammatory actions by targeting IKKβ inhibition in LPS-activated macrophages. , 2014, Free radical biology & medicine.

[21]  Baochang Cai,et al.  Fourier Transform Near-Infrared Spectroscopy Used for Purity Determination of Rhein-L-arginine Cocrystal (Argirein) , 2013, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[22]  Xuegang Li,et al.  Synthesis and hypoglycemic activity evaluation of rhein amide derivatives , 2013, Medicinal Chemistry Research.

[23]  D. Dai,et al.  ER Stress, P66shc, and P-Akt/Akt Mediate Adjuvant-Induced Inflammation, Which Is Blunted by Argirein, a Supermolecule and Rhein in Rats , 2012, Inflammation.

[24]  P. Maršík,et al.  Active constituents in Rheum acuminatum and Rheum australe (Polygonaceae) roots: A variation between cultivated and naturally growing plants , 2012 .

[25]  Miranda L. Cheney,et al.  Coformer selection in pharmaceutical cocrystal development: a case study of a meloxicam aspirin cocrystal that exhibits enhanced solubility and pharmacokinetics. , 2011, Journal of pharmaceutical sciences.

[26]  Christopher A. Hunter,et al.  Virtual cocrystal screening , 2011 .

[27]  S. Ignacimuthu,et al.  Antifeedant and larvicidal activities of Rhein isolated from the flowers of Cassia fistula L. , 2011, Saudi journal of biological sciences.

[28]  Valter Travagli,et al.  Solubility, spectroscopic properties and photostability of Rhein/cyclodextrin inclusion complex. , 2009, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[29]  Kengo Kinoshita,et al.  Analyses of homo-oligomer interfaces of proteins from the complementarity of molecular surface, electrostatic potential and hydrophobicity. , 2006, Protein engineering, design & selection : PEDS.