Clonal analysis of sacrococcygeal "teratomas".

Congenital masses of the sacrococcygeal region commonly contain multiple tissues and have variously been subclassified as neoplasms or congenital hamartomas based on clinicopathological and embryological observations. We have used a polymerase chain reaction-based assay for nonrandom X chromosome inactivation to infer the clonality of three cogenital sacrococcygeal tumors previously diagnosed as teratomas. One solid immature teratoma was monoclonal, and a predominantly cystic histologically mature mass was polyclonal. A third immature teratoma was noninformative because of baseline asymmetry of polyclonal tissue X inactivation. We confirm that immature teratomas at this site appear to be monoclonal neoplasms and suggest that at least some histologically mature "teratomas" are more appropriately classified as hamartomas.

[1]  G. Mutter,et al.  PCR bias in amplification of androgen receptor alleles, a trinucleotide repeat marker used in clonality studies. , 1995, Nucleic acids research.

[2]  J. Fletcher,et al.  A polymerase chain reaction assay for non-random X chromosome inactivation identifies monoclonal endometrial cancers and precancers. , 1995, The American journal of pathology.

[3]  K. Shroyer,et al.  Analysis of clonality in archival tissues by polymerase chain reaction amplification of PGK-1. , 1994, Human pathology.

[4]  G. Hansson,et al.  Sacrococcygeal teratoma in Sweden: a 10-year national retrospective study. , 1992, Journal of pediatric surgery.

[5]  G. Pinkus,et al.  Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp , 1992, Genes, chromosomes & cancer.

[6]  D. Shibata,et al.  Specific genetic analysis of microscopic tissue after selective ultraviolet radiation fractionation and the polymerase chain reaction. , 1992, The American journal of pathology.

[7]  M. Lyon,et al.  Some milestones in the history of X-chromosome inactivation. , 1992, Annual review of genetics.

[8]  H. Zoghbi,et al.  Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. , 1992, American journal of human genetics.

[9]  R. Willemze,et al.  Studies on clonality by PCR analysis of the PGK-1 gene. , 1991, Nucleic acids research.

[10]  G. Pinkus,et al.  Lineage-restricted clonality in biphasic solid tumors. , 1991, The American journal of pathology.

[11]  G. Mutter.  Teratoma genetics and stem cells: a review. , 1987, Obstetrical & gynecological survey.

[12]  G. Mahour,et al.  Sacrococcygeal teratomas in infants and children. , 1985, American journal of surgery.

[13]  A. Feinberg,et al.  Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors. , 1985, Science.

[14]  G. Vawter,et al.  Sacrococcygeal germ cell tumors in childhood: an updated experience with 118 patients. , 1981, Journal of pediatric surgery.

[15]  F. Gonzalez-crussi,et al.  Sacrococcygeal teratomas in infants and children: relationship of histology and prognosis in 40 cases. , 1978, Archives of pathology & laboratory medicine.

[16]  L. Rorke,et al.  Midline hamartomas masquerading as meningomyeloceles or teratomas in the newborn infant. , 1976, The Journal of pediatrics.

[17]  H. Norris,et al.  Immature (malignant) teratoma of the ovary. A clinical and pathologic study of 58 cases , 1976, Cancer.

[18]  P. Fialkow.  Primordial cell pool size and lineage relationships of five human cell types* , 1973, Annals of human genetics.

[19]  M. T. Salaymeh.  Giant sacrococcygeal teratoma in the newborn , 1972 .

[20]  P. Fialkow.  Use of genetic markers to study cellular origin and development of tumors in human females. , 1972, Advances in cancer research.

[21]  Salaymeh Mt.  Giant sacrococcygeal teratoma in the newborn. Case report and review of the literature. , 1971 .

[22]  L. Falin.  The development of genital glands and the origin of germ cells in human embryogenesis. , 1969, Acta anatomica.

[23]  S. Gartler,et al.  Glucose-6-Phosphate Dehydrogenase Mosaicism: Utilization as a Cell Marker in the Study of Leiomyomas , 1965, Science.

[24]  A. Stout,et al.  PERIANAL CYSTS OF VESTIGIAL ORIGIN , 1938 .

[25]  R. Raven.  Sacro‐coccygeal cysts and tumours , 1935 .