EVIDENCE FOR AN INFECTIVE CAUSE OF CHILDHOOD LEUKAEMIA: COMPARISON OF A SCOTTISH NEW TOWN WITH NUCLEAR REPROCESSING SITES IN BRITAIN

Increases of leukaemia in young people that cannot be explained in terms of radiation have been recorded near both of Britain's nuclear reprocessing plants at Dounreay and Sellafield. These were built in unusually isolated places where herd immunity to a postulated widespread virus infection (to which leukaemia is a rare response) would tend to be lower than average. The large influxes of people in the 1950s to those areas might have been conducive to epidemics. The hypothesis has been tested in Scotland in an area identified at the outset as the only other rural area that received a large influx at the same time, when it was much more cut off from the nearest conurbation than at present--the New Town of Glenrothes. A significant increase of leukaemia below age 25 was found (10 observed, expected 3.6), with a greater excess below age 5 (7 observed, expected 1.5).

[1]  J. Yorke,et al.  Seasonality and the requirements for perpetuation and eradication of viruses in populations. , 1979, American journal of epidemiology.

[2]  J. Urquhart,et al.  CHILDHOOD LEUKAEMIA IN NORTHERN SCOTLAND , 1986, The Lancet.

[3]  M. Gardner,et al.  MORTALITY IN CUMBERLAND DURING 1959-78 WITH REFERENCE TO CANCER IN YOUNG PEOPLE AROUND WINDSCALE , 1984, The Lancet.

[4]  M. Gardner,et al.  Follow up study of children born to mothers resident in Seascale, West Cumbria (birth cohort). , 1987, British medical journal.

[5]  D. Francis,et al.  Increased risk for lymphoma and glomerulonephritis in a closed population of cats exposed to feline leukemia virus. , 1980, American Journal of Epidemiology.

[6]  A. Craft,et al.  CHILDHOOD CANCER IN CUMBRIA , 1983, The Lancet.

[7]  M. Bartlett Measles Periodicity and Community Size , 1957 .

[8]  James Cutler,et al.  CANCER IN CUMBRIA: THE WINDSCALE CONNECTION , 1984, The Lancet.

[9]  Macfarlane Burnet,et al.  Natural history of infectious disease , 1953 .

[10]  M. Gardner,et al.  Follow up study of children born elsewhere but attending schools in Seascale, West Cumbria (schools cohort). , 1987, British medical journal.

[11]  R. Doll,et al.  Fallout, radiation doses near Dounreay, and childhood leukaemia. , 1987, British medical journal.

[12]  D. Macgregor A survey of the social and economic effects of the forth road bridge with particular reference to the county of fife , 1966 .

[13]  I. Kemp,et al.  Leukaemia in young persons in Scotland: a study of its geographical distribution and relationship to nuclear installations. , 1987, Health bulletin.

[14]  D. Tyrrell,et al.  Common colds and related diseases. , 1965, British medical bulletin.