Vacuolar protein sorting 35 (VPS35) acts as a tumor promoter via facilitating cell cycle progression in pancreatic ductal adenocarcinoma

[1]  Tiejun Chen,et al.  Vacuolar protein sorting-associated protein 72 homolog (VPS72) binding to lysine acetyltransferase 5 (KAT5) promotes the proliferation, invasion and migration of hepatocellular carcinoma through regulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway , 2022, Bioengineered.

[2]  S. Goel,et al.  Targeting CDK4 and CDK6 in cancer , 2022, Nature Reviews Cancer.

[3]  Huan-min Niu,et al.  Overexpression of VPS16 correlates with tumor progression and chemoresistance in colorectal cancer. , 2022, Biochemical and biophysical research communications.

[4]  J. Durivault,et al.  Pancreatic Ductal Adenocarcinoma: The Dawn of the Era of Nuclear Medicine? , 2021, International journal of molecular sciences.

[5]  J. Rosenfeld,et al.  Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking , 2021, Brain : a journal of neurology.

[6]  B. Mania-Farnell,et al.  Advanced Pediatric Diffuse Pontine Glioma Murine Models Pave the Way towards Precision Medicine , 2021, Cancers.

[7]  M. Jücker,et al.  The Role of mTOR Signaling as a Therapeutic Target in Cancer , 2021, International journal of molecular sciences.

[8]  Zhiyong Gao,et al.  Circ-PRKDC Facilitates the Progression of Colorectal Cancer Through miR-198/DDR1 Regulatory Axis , 2020, Cancer management and research.

[9]  I. Endo,et al.  High G2M Pathway Score Pancreatic Cancer is Associated with Worse Survival, Particularly after Margin-Positive (R1 or R2) Resection , 2020, Cancers.

[10]  M. Mansukhani,et al.  Diffuse midline glioma with novel, potentially targetable, FGFR2–VPS35 fusion , 2020, Cold Spring Harbor molecular case studies.

[11]  Charles R. Thomas,et al.  Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma , 2020, CA: a cancer journal for clinicians.

[12]  K. Ding,et al.  DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinoma , 2020, Oncogene.

[13]  Vacuolar Protein Sorting , 2020, Definitions.

[14]  K. Tennekoon,et al.  Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance. , 2019, Seminars in cancer biology.

[15]  H. Hua,et al.  Targeting mTOR for cancer therapy , 2019, Journal of Hematology & Oncology.

[16]  G. Leone,et al.  The broken cycle: E2F dysfunction in cancer , 2019, Nature Reviews Cancer.

[17]  B. Morrison,et al.  Contributions of VPS35 Mutations to Parkinson’s Disease , 2019, Neuroscience.

[18]  Ying Jiang,et al.  Identification and validation of alternative splicing isoforms as novel biomarker candidates in hepatocellular carcinoma. , 2018, Oncology reports.

[19]  Dirk Mossmann,et al.  mTOR signalling and cellular metabolism are mutual determinants in cancer , 2018, Nature Reviews Cancer.

[20]  K. Wennerberg,et al.  Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib. , 2018, Cancer letters.

[21]  J. Iovanna,et al.  E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments , 2018, Scientific Reports.

[22]  Fei Zhang,et al.  Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells , 2017, Journal of Experimental & Clinical Cancer Research.

[23]  M. Lucas,et al.  Retromer , 2017, Current Biology.

[24]  M. Falasca,et al.  Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies , 2017, International journal of molecular sciences.

[25]  J. Pipas,et al.  Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma , 2017, The Journal of clinical investigation.

[26]  Xi Chen,et al.  VPS35, the Retromer Complex and Parkinson’s Disease , 2017, Journal of Parkinson's disease.

[27]  Jin Chen,et al.  mTORC1 and mTORC2 in cancer and the tumor microenvironment , 2016, Oncogene.

[28]  Yong Zhou,et al.  VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking , 2016, The Journal of cell biology.

[29]  Xiaohong Xu,et al.  Cell adhesion down-regulates the expression of vacuolar protein sorting 4B (VPS4B) and contributes to drug resistance in multiple myeloma cells , 2015, International Journal of Hematology.

[30]  R. Ni,et al.  High expression of vacuolar protein sorting 4B (VPS4B) is associated with accelerated cell proliferation and poor prognosis in human hepatocellular carcinoma. , 2015, Pathology, research and practice.

[31]  Aris Fiser,et al.  Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration , 2014, Human molecular genetics.

[32]  R. Nicoll,et al.  Retromer Mediates a Discrete Route of Local Membrane Delivery to Dendrites , 2014, Neuron.

[33]  Qiang Sun,et al.  Gallotannin Imposes S Phase Arrest in Breast Cancer Cells and Suppresses the Growth of Triple-Negative Tumors In Vivo , 2014, PloS one.

[34]  C. Wan,et al.  Vacuolar protein sorting 4B, an ATPase protein positively regulates the progression of NSCLC via promoting cell division , 2013, Molecular and Cellular Biochemistry.

[35]  C. Wan,et al.  Vacuolar protein sorting 4B, an ATPase protein positively regulates the progression of NSCLC via promoting cell division , 2013, Molecular and Cellular Biochemistry.

[36]  M. Seaman The retromer complex – endosomal protein recycling and beyond , 2012, Journal of Cell Science.

[37]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[38]  D. Teis,et al.  The ESCRT machinery , 2012, Current Biology.

[39]  Masakazu Yamamoto,et al.  Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas , 2011, Scientific reports.

[40]  Marc N. Offman,et al.  A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. , 2011, American journal of human genetics.

[41]  W. Sundquist,et al.  Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance , 2010, Proceedings of the National Academy of Sciences.

[42]  M. Barbacid,et al.  Cell cycle, CDKs and cancer: a changing paradigm , 2009, Nature Reviews Cancer.

[43]  L. Honig,et al.  Model‐guided microarray implicates the retromer complex in Alzheimer's disease , 2005, Annals of neurology.

[44]  A. Inui,et al.  Therapy Insight: cancer anorexia–cachexia syndrome—when all you can eat is yourself , 2005, Nature Clinical Practice Oncology.

[45]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[46]  K. Vermeulen,et al.  The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer , 2003, Cell proliferation.

[47]  J. Bartek,et al.  Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. , 2003, Cancer cell.

[48]  Victor X. Jin,et al.  Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle-Related Transcription and Attenuated Androgen Response. , 2018, Cancer research.

[49]  D. Yalnızoǧlu,et al.  A probable new syndrome with the storage disease phenotype caused by the VPS33A gene mutation , 2017, Clinical dysmorphology.

[50]  Manuel Hidalgo,et al.  Addressing the challenges of pancreatic cancer: future directions for improving outcomes. , 2015, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[51]  N. Yoo,et al.  Frameshift mutations of vacuolar protein sorting genes in gastric and colorectal cancers with microsatellite instability. , 2012, Human pathology.

[52]  G. Stark,et al.  Analyzing the G2/M checkpoint. , 2004, Methods in molecular biology.