The Cellulose Synthase Superfamily 1

The availability of a nearly complete genome sequence for Arabidopsis has created many novel op-portunities to identify, by computational methods, the genes that encode enzymes, which have been difficult to characterize by conventional means. We have used this approach to identify a large family of genes of unknown function that show sequence similarity to cellulose synthase. Our working hypothesis is that these genes encode enzymes that catalyze the synthesis of non-cellulosic polysaccharides (Cutler and Somerville, 1997).

[1]  I. Bach The LIM domain: regulation by association , 2000, Mechanisms of Development.

[2]  P. Freemont Ubiquitination: RING for destruction? , 2000, Current Biology.

[3]  Deborah P. Delmer,et al.  CELLULOSE BIOSYNTHESIS: Exciting Times for A Difficult Field of Study. , 1999, Annual review of plant physiology and plant molecular biology.

[4]  S. Cutler,et al.  The irregular xylem3 locus of Arabidopsis encodes a cellulose synthase required for secondary cell wall synthesis. , 1999, The Plant cell.

[5]  P. Broun,et al.  Catalytic plasticity of fatty acid modification enzymes underlying chemical diversity of plant lipids. , 1998, Science.

[6]  S J de Souza,et al.  Toward a resolution of the introns early/late debate: only phase zero introns are correlated with the structure of ancient proteins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[7]  W Herth,et al.  Molecular analysis of cellulose biosynthesis in Arabidopsis. , 1998, Science.

[8]  C. Somerville,et al.  Collapsed xylem phenotype of Arabidopsis identifies mutants deficient in cellulose deposition in the secondary cell wall. , 1997, The Plant cell.

[9]  D. Delmer,et al.  Higher plants contain homologs of the bacterial celA genes encoding the catalytic subunit of cellulose synthase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[10]  B. Muller,et al.  Characterization of the Cell-Wall Polysaccharides of Arabidopsis thaliana Leaves , 1995, Plant physiology.

[11]  B. Henrissat,et al.  Multidomain architecture of beta-glycosyl transferases: implications for mechanism of action , 1995, Journal of bacteriology.

[12]  P. Fisher,et al.  Detection of two loci involved in (1-->3)-beta-glucan (curdlan) biosynthesis by Agrobacterium sp. ATCC31749, and comparative sequence analysis of the putative curdlan synthase gene. , 1999, Glycobiology.

[13]  Bulone,et al.  A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities , 1998, The Biochemical journal.

[14]  D. Delmer,et al.  Pathways and genes involved in cellulose biosynthesis. , 1997, Genetic engineering.