Structures of Ebola Virus GP and sGP in Complex with Therapeutic Antibodies

[1]  Jens Meiler,et al.  Web‐accessible molecular modeling with Rosetta: The Rosetta Online Server that Includes Everyone (ROSIE) , 2018, Protein science : a publication of the Protein Society.

[2]  Erin E. H. Tran,et al.  Mapping of Ebolavirus Neutralization by Monoclonal Antibodies in the ZMapp Cocktail Using Cryo-Electron Tomography and Studies of Cellular Entry , 2016, Journal of Virology.

[3]  Ben M. Webb,et al.  Comparative Protein Structure Modeling Using MODELLER , 2016, Current protocols in bioinformatics.

[4]  G. Gao,et al.  Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection , 2016, Cell.

[5]  U. Baxa,et al.  Structural and molecular basis for Ebola virus neutralization by protective human antibodies , 2016, Science.

[6]  K. Chandran,et al.  Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies , 2016, mBio.

[7]  James E. Crowe,et al.  Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection , 2016, Cell.

[8]  James D. Campbell,et al.  Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial , 2016, The Lancet. Infectious diseases.

[9]  Keith S Wilson,et al.  Privateer: software for the conformational validation of carbohydrate structures , 2015, Nature Structural &Molecular Biology.

[10]  John-Arne Røttingen,et al.  Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial , 2015, The Lancet.

[11]  J. Rucker,et al.  Mechanism of Binding to Ebola Virus Glycoprotein by the ZMapp, ZMAb, and MB-003 Cocktail Antibodies , 2015, Journal of Virology.

[12]  Pardis C. Sabeti,et al.  Monitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in Liberia , 2015, Emerging infectious diseases.

[13]  James E. Crowe,et al.  Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus , 2015, Cell.

[14]  Matthias J. Brunner,et al.  Atomic accuracy models from 4.5 Å cryo-electron microscopy data with density-guided iterative local refinement , 2015, Nature Methods.

[15]  Nathaniel Echols,et al.  EMRinger: Side-chain-directed model and map validation for 3D Electron Cryomicroscopy , 2015, Nature Methods.

[16]  X. Qiu,et al.  The multiple roles of sGP in Ebola pathogenesis. , 2015, Viral immunology.

[17]  X. Qiu,et al.  Structures of protective antibodies reveal sites of vulnerability on Ebola virus , 2014, Proceedings of the National Academy of Sciences.

[18]  G. Gao,et al.  Molecular Characterization of the Monoclonal Antibodies Composing ZMAb: A Protective Cocktail Against Ebola Virus , 2014, Scientific Reports.

[19]  Rachel S. G. Sealfon,et al.  Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak , 2014, Science.

[20]  Mario Roederer,et al.  Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge , 2014, Nature Medicine.

[21]  J. Strong,et al.  Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp™ , 2014, Nature.

[22]  J. Ravetch,et al.  Type I and type II Fc receptors regulate innate and adaptive immunity , 2014, Nature Immunology.

[23]  X. Qiu,et al.  Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb , 2013, Scientific Reports.

[24]  Dafna M. Abelson,et al.  Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle , 2013, Cell.

[25]  D. Agard,et al.  Electron counting and beam-induced motion correction enable near atomic resolution single particle cryoEM , 2013, Nature Methods.

[26]  Brian D. Weitzner,et al.  Serverification of Molecular Modeling Applications: The Rosetta Online Server That Includes Everyone (ROSIE) , 2013, PloS one.

[27]  K. Katoh,et al.  MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability , 2013, Molecular biology and evolution.

[28]  Sjors H.W. Scheres,et al.  RELION: Implementation of a Bayesian approach to cryo-EM structure determination , 2012, Journal of structural biology.

[29]  Lisa Hensley,et al.  Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques , 2012, Proceedings of the National Academy of Sciences.

[30]  Shaoxia Chen,et al.  Prevention of overfitting in cryo-EM structure determination , 2012, Nature Methods.

[31]  X. Qiu,et al.  Successful Treatment of Ebola Virus–Infected Cynomolgus Macaques with Monoclonal Antibodies , 2012, Science Translational Medicine.

[32]  Xueming Li,et al.  Fabs enable single particle cryoEM studies of small proteins. , 2012, Structure.

[33]  N. Bohorova,et al.  Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant , 2011, Proceedings of the National Academy of Sciences.

[34]  V. Volchkov,et al.  Genomic RNA editing and its impact on Ebola virus adaptation during serial passages in cell culture and infection of guinea pigs. , 2011, The Journal of infectious diseases.

[35]  X. Qiu,et al.  Characterization of Zaire ebolavirus glycoprotein-specific monoclonal antibodies. , 2011, Clinical immunology.

[36]  Kathryn L. Schornberg,et al.  Cathepsin Cleavage Potentiates the Ebola Virus Glycoprotein To Undergo a Subsequent Fusion-Relevant Conformational Change , 2011, Journal of Virology.

[37]  Yoshihiro Kawaoka,et al.  A Shared Structural Solution for Neutralizing Ebolaviruses , 2011, Nature Structural &Molecular Biology.

[38]  Vincent B. Chen,et al.  Correspondence e-mail: , 2000 .

[39]  E. Saphire,et al.  Ebolavirus glycoprotein structure and mechanism of entry. , 2009, Future virology.

[40]  Dafna M. Abelson,et al.  Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein. , 2009, Acta crystallographica. Section D, Biological crystallography.

[41]  D. Baker,et al.  Refinement of protein structures into low-resolution density maps using rosetta. , 2009, Journal of molecular biology.

[42]  M Radermacher,et al.  DoG Picker and TiltPicker: software tools to facilitate particle selection in single particle electron microscopy. , 2009, Journal of structural biology.

[43]  Jeffrey J. Gray,et al.  Toward high‐resolution homology modeling of antibody Fv regions and application to antibody–antigen docking , 2009, Proteins.

[44]  D. Burton,et al.  Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor , 2008, Nature.

[45]  Ben M. Webb,et al.  Comparative Protein Structure Modeling Using MODELLER , 2007, Current protocols in protein science.

[46]  D. Burton,et al.  Neutralizing Antibody Fails to Impact the Course of Ebola Virus Infection in Monkeys , 2007, PLoS pathogens.

[47]  Claus-Wilhelm von der Lieth,et al.  GlyProt: in silico glycosylation of proteins , 2005, Nucleic Acids Res..

[48]  Martin Frank,et al.  Carbohydrate Structure Suite (CSS): analysis of carbohydrate 3D structures derived from the PDB , 2004, Nucleic Acids Res..

[49]  Kevin Cowtan,et al.  research papers Acta Crystallographica Section D Biological , 2005 .

[50]  A. Sanchez,et al.  Disulfide bond assignment of the Ebola virus secreted glycoprotein SGP. , 2004, Biochemical and biophysical research communications.

[51]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[52]  N. Grigorieff,et al.  Accurate determination of local defocus and specimen tilt in electron microscopy. , 2003, Journal of structural biology.

[53]  J. Wilson,et al.  Epitopes involved in antibody-mediated protection from Ebola virus. , 2000, Science.

[54]  H. Feldmann,et al.  The nonstructural small glycoprotein sGP of Ebola virus is secreted as an antiparallel-orientated homodimer. , 1998, Virology.

[55]  A. Sanchez,et al.  Biochemical Analysis of the Secreted and Virion Glycoproteins of Ebola Virus , 1998, Journal of Virology.

[56]  A. Sanchez,et al.  The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[57]  D. Dassey.  Outbreak , 1995, The Lancet.