Human yolk sac tumor serially transplanted in nude mice: Its morphologic and functional properties

Three human yolk sac tumors (TE, OE, and TT‐1) were serially transplanted into nude mice. The histology of the transplanted tumors is moderately different from that of the original tumor: the transplants had mainly a tubular structure with an inconspicuous endodermal sinus structure due to a decreased mesenchymal element surrounding the vascular core. Ultrastructural features of the transplanted tumor cells, however, were identical to those of the original tumor.

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