Microarray Experiment Design and Statistical Analysis

Microarray technology is a new kid on the block for biological researchers, and it has shown a great potential in many fields. While biologists are thrilled by the power of this new technology, they are also over-whelmed by the enormous amount of data generated, and often feel uncomfortable about how to extract useful information from the data. On one hand, there is always some information to be mined in such big data sets; on the other hand, it is almost certain that spurious findings will result even if extreme care has been exercised in mining the data. This challenge mandates interdisciplinary cooperation among biologists, statisticians and computer scientists. Although research in this area is still in its infancy, it is our goal in this chapter to discuss some of the most prominent issues in experiment design and statistical analysis for microarray research and to present possible solutions to some of these problems.

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