Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

[1]  J. Bertin,et al.  Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes1 , 2006, The Journal of Immunology.

[2]  D. Kastner,et al.  Familial autoinflammatory diseases: genetics, pathogenesis and treatment , 2005, Current opinion in rheumatology.

[3]  L. Liau,et al.  The TLR7 Agonist Imiquimod Enhances the Anti-Melanoma Effects of a Recombinant Listeria monocytogenes Vaccine1 , 2005, The Journal of Immunology.

[4]  Houping Ni,et al.  Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. , 2005, Immunity.

[5]  M. Chamaillard,et al.  NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. , 2005, Annual review of biochemistry.

[6]  Richard A. Flavell,et al.  Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract , 2005, Science.

[7]  F. Martinon,et al.  Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome , 2004, Current Biology.

[8]  R. Janssen,et al.  Enhanced interleukin-1β and interleukin-18 release in a patient with chronic infantile neurologic, cutaneous, articular syndrome , 2004 .

[9]  V. Dixit,et al.  Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf , 2004, Nature.

[10]  P. Vandenabeele,et al.  Caspase-1 Activates Nuclear Factor of the κ-Enhancer in B Cells Independently of Its Enzymatic Activity* , 2004, Journal of Biological Chemistry.

[11]  G. Núñez,et al.  Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. , 2004, The Journal of biological chemistry.

[12]  Akiko Iwasaki,et al.  Recognition of single-stranded RNA viruses by Toll-like receptor 7. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[13]  D. Weissman,et al.  Cutting Edge: Innate Immune System Discriminates between RNA Containing Bacterial versus Eukaryotic Structural Features That Prime for High-Level IL-12 Secretion by Dendritic Cells1 , 2004, The Journal of Immunology.

[14]  Shizuo Akira,et al.  Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA , 2004, Science.

[15]  S. Akira,et al.  Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8 , 2004, Science.

[16]  F. Martinon,et al.  NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. , 2004, Immunity.

[17]  D. Philpott,et al.  Innate immunity via Toll-like receptors and Nod proteins. , 2004, Current opinion in microbiology.

[18]  J. Ting,et al.  Cutting Edge: CIAS1/Cryopyrin/PYPAF1/NALP3/ CATERPILLER 1.1 Is an Inducible Inflammatory Mediator with NF-κB Suppressive Properties , 2003, The Journal of Immunology.

[19]  H. Wagner,et al.  Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848 , 2002, Nature Immunology.

[20]  S. Akira,et al.  Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway , 2002, Nature Immunology.

[21]  G. Kinghorn,et al.  Imiquimod and resiquimod as novel immunomodulators. , 2001, The Journal of antimicrobial chemotherapy.

[22]  R. Marks,et al.  Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-week dose-response trial. , 2001, Journal of the American Academy of Dermatology.

[23]  C. Gabel,et al.  ATP Acts as an Agonist to Promote Stimulus-Induced Secretion of IL-1β and IL-18 in Human Blood , 2000, The Journal of Immunology.

[24]  M. Netea,et al.  Interleukin‐18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin‐1β , 2000, European journal of immunology.

[25]  C. Dinarello.  Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzyme a , 1998 .

[26]  R. Miller,et al.  Immunomodulating and antiviral activities of the imidazoquinoline S-28463. , 1995, Antiviral research.

[27]  D. Bernstein,et al.  Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection. , 1988, Antiviral research.