Absorption of radioactive vitamin B12 after total gastrectomy; relation to macrocytic anemia and to the site of origin of Castle's intrinsic factor.

Twenty-five years ago Castle1 showed that the oral administration of normal gastric juice mixed with beef muscle to patients with pernicious anemia resulted in a hematologic response, although neither substance was effective by itself. This led to the concept that pernicious anemia is caused by deficiency of a gastric or "intrinsic factor" that normally reacts with an "extrinsic" or food factor to produce a substance necessary for hematopoiesis. The intrinsic factor was found to be present not only in normal human gastric juice but also in the intestinal and gastric mucosa of other animal species, particularly swine.2 Since 1929 a . . .

[1]  S. Callender,et al.  Estimation of Intrinsic Factor of Castle by Use of Radioactive Vitamin B12 , 1954, British medical journal.

[2]  W. Castle.  Development of knowledge concerning the gastric intrinsic factor and its relation to pernicious anemia. , 1953, The New England journal of medicine.

[3]  M. Swendseid,et al.  Excretion of Cobalt60-Labeled Vitamin B12 after Total Gastrectomy.∗ , 1953 .

[4]  R. Wallerstein,et al.  Observations on the etiologic relationship of achylia gastrica to pernicious anemia. XV. Hematopoietic effects of simultaneous intravenous and of simultaneous or serial oral administration of intrinsic factor and vitamin B12. , 1953, The Journal of laboratory and clinical medicine.

[5]  W. Castle,et al.  OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA: XIV. Intrinsic Factor Activity of Desiccated and Defatted Human Fundus, Duodenum, and Jejunum , 1952, The American journal of the medical sciences.

[6]  C. Conley,et al.  Observations on the absorption, utilization, and excretion of vitamin B12. , 1951, The Journal of laboratory and clinical medicine.

[7]  R. Girdwood.  The intestinal content in pernicious anemia of factors for the growth of Streptococcus faecalis and Lactobacillus leichmannii. , 1950, Blood.

[8]  M. Paulson,et al.  I. ABSENCE OF INTRINSIC FACTOR FROM INTESTINAL JUICE OF PATIENTS FOLLOWING TOTAL GASTRECTOMY° , 1950, The American journal of the medical sciences.

[9]  L. Chaiet,et al.  Biosynthesis of radioactive vitamin B12 containing cobalt 60. , 1950, Science.

[10]  J. Harris,et al.  OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA , 1929 .

[11]  F. Ingelfinger,et al.  Late effects of total gastrectomy in man. , 1947, The New England journal of medicine.

[12]  S. Schwartz,et al.  RELAPSES IN PERNICIOUS ANEMIA , 1944 .

[13]  W. Castle,et al.  OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA: IX. Difference in Site of Secretion of Intrinsic Factor in the Hog and in the Human Stomach , 1942 .

[14]  S. M. Goldhamer,et al.  MACROCYTIC ANEMIA, OTHER THAN PERNICIOUS ANEMIA, ASSOCIATED WITH LESIONS OF THE GASTROINTESTINAL TRACT , 1939 .

[15]  H. Magnus,et al.  THE GASTRIC LESION IN PERNICIOUS ANÆMIA , 1938 .

[16]  S. Simpson,et al.  ADDISONIAN ANEMIA FOLLOWING GASTRECTOMY AND GASTRO-JEJUNOSTOMY , 1932 .

[17]  C. Heath,et al.  OBSERVATIONS ON THE ETIOLOGIC RELATIONSHIP OF ACHYLIA GASTRICA TO PERNICIOUS ANEMIA.: III. THE NATURE OF THE REACTION BETWEEN NORMAL HUMAN GASTRIC JUICE AND BEEF MUSCLE LEADING TO CLINICAL IMPROVEMENT AND INCREASED BLOOD FORMATION SIMILAR TO THE EFFECT OF LIVER FEEDING , 1930 .

[18]  C. C. Sturgis,et al.  DESICCATED STOMACH IN THE TREATMENT OF PERNICIOUS ANEMIA , 1929 .