Scale-Up of Agitation Fluidized Bed Granulation. I. Preliminary Experimental Approach for Optimization of Process Variables

Granulation scale-up with an agitation fluidized bed of three sizes (vessel diameter 125, 230, 500 mm) was preliminary investigated. In order to evaluate accurately the scale-up factor on granule properties, process variables such as spray conditions, method for moisture measurement and control, powder feed weight and drying efficiency were optimized.