Imiquimod as an adjuvant treatment measure for desmoplastic trichoepithelioma.

Desmoplastic trichoepithelioma is a rare benign adnexal tumor. Although it is a benign lesion, patients often want to treat it due to cosmetic concerns when it occurs in an easily visible site. For our two cases, topical 5% imiquimod was an attractive treatment option as it is applied by the patients themselves and it has minimal side effects, including leaving no scar. However, the lesions recurred after clinical remission. To the best of our knowledge, this is the only report on utilizing imiquimod to treat a benign adnexal tumor, and especially desmoplastic trichoepithelioma.

[1]  M. Kim,et al.  Multiple scrotal epidermolytic acanthomas successfully treated with topical imiquimod , 2007, The Journal of dermatology.

[2]  S. Chang,et al.  Case of linear porokeratosis: Successful treatment with topical 5% imiquimod cream , 2007, The Journal of dermatology.

[3]  H. Ko,et al.  Infiltrative Trichilemmal Carcinoma Treated with 5% Imiquimod Cream , 2005, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[4]  D. Sauder,et al.  Imiquimod: modes of action , 2003 .

[5]  S. Akira,et al.  Interferon-α and Interleukin-12 Are Induced Differentially by Toll-like Receptor 7 Ligands in Human Blood Dendritic Cell Subsets , 2002, The Journal of experimental medicine.

[6]  E. Ross,et al.  The use of the 1.0 mm handpiece in high energy, pulsed CO2 laser destruction of facial adnexal tumors. , 1999, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[7]  M. Shaffelburg,et al.  Treatment of multiple trichoepithelioma with electrosurgery. , 1998, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[8]  D. Massi,et al.  Desmoplastic trichoepithelioma , 1998, The Australasian journal of dermatology.

[9]  L. Shapiro,et al.  Desmoplastic trichoepithelioma , 1977, Cancer.