Discovery of a novel small molecule with efficacy in protecting against inflammation in vitro and in vivo by enhancing macrophages activation.

[1]  D. Xie,et al.  A Novel Prenylflavonoid Icariside I Ameliorates Estrogen Deficiency-Induced Osteoporosis via Simultaneous Regulation of Osteoblast and Osteoclast Differentiation. , 2023, ACS pharmacology & translational science.

[2]  Xiang Zhang,et al.  Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites in Mice , 2022, Engineering.

[3]  Limin Zhang,et al.  Structural Insights into Amelioration Effects of Quercetin and Its Glycoside Derivatives on NAFLD in Mice by Modulating the Gut Microbiota and Host Metabolism. , 2022, Journal of agricultural and food chemistry.

[4]  S. Nie,et al.  Protective effects of flavonoids isolated from Agrocybe aegirita on dextran sodium sulfate-induced colitis , 2022, eFood.

[5]  H. Tilg,et al.  Gut microbiome and health: mechanistic insights , 2022, Gut.

[6]  Limin Zhang,et al.  In Vitro and In Vivo Studies Reveal that Hesperetin-7-O-glucoside, a Naturally Occurring Monoglucoside, Exhibits Strong Anti-inflammatory Capacity. , 2021, Journal of agricultural and food chemistry.

[7]  A. Vella,et al.  What to do about the leaky gut , 2021, Gut.

[8]  Jinxia Wang,et al.  The Flavonoid Kurarinone Regulates Macrophage Functions via Aryl Hydrocarbon Receptor and Alleviates Intestinal Inflammation in Irritable Bowel Syndrome , 2021, Journal of inflammation research.

[9]  T. Hoashi,et al.  The Defect in Regulatory T Cells in Psoriasis and Therapeutic Approaches , 2021, Journal of clinical medicine.

[10]  Limin Zhang,et al.  Microbiome analysis combined with targeted metabolomics reveal immunological anti-tumor activity of icariside I in a melanoma mouse model. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[11]  B. Stockinger,et al.  AHR in the intestinal microenvironment: safeguarding barrier function , 2021, Nature Reviews Gastroenterology & Hepatology.

[12]  Y. Cong,et al.  Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases , 2021, Cellular & Molecular Immunology.

[13]  Le Zhang,et al.  Dietary Taxifolin Protects Against Dextran Sulfate Sodium-Induced Colitis via NF-κB Signaling, Enhancing Intestinal Barrier and Modulating Gut Microbiota , 2021, Frontiers in Immunology.

[14]  F. Zheng,et al.  Yeast β-glucan, a potential prebiotic, showed a similar probiotic activity to inulin. , 2020, Food & function.

[15]  F. Powrie,et al.  Host–microbiota maladaptation in colorectal cancer , 2020, Nature.

[16]  Jingjing Fu,et al.  Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor , 2020, Proceedings of the National Academy of Sciences.

[17]  Wenjing Zhao,et al.  The microbiome in inflammatory bowel diseases: from pathogenesis to therapy , 2020, Protein & Cell.

[18]  Xiao-dong Liu,et al.  Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine , 2020, Acta Pharmacologica Sinica.

[19]  Jun Yu,et al.  High-Fat Diet Promotes Colorectal Tumorigenesis through Modulating Gut Microbiota and Metabolites. , 2020, Gastroenterology.

[20]  H. Sokol,et al.  Gut microbiota-derived metabolites as key actors in inflammatory bowel disease , 2020, Nature Reviews Gastroenterology & Hepatology.

[21]  G. Núñez,et al.  Host–microbiota interactions in inflammatory bowel disease , 2020, Nature Reviews Immunology.

[22]  N. Segata,et al.  Endogenous murine microbiota member Faecalibaculum rodentium and its human homolog protect from intestinal tumor growth , 2019, Nature Microbiology.

[23]  Lanjuan Li,et al.  Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice , 2019, Front. Microbiol..

[24]  G. Matteoli,et al.  Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD , 2019, Nature Reviews Gastroenterology & Hepatology.

[25]  M. Camilleri Leaky gut: mechanisms, measurement and clinical implications in humans , 2019, Gut.

[26]  F. Quintana,et al.  The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease , 2019, Nature Reviews Immunology.

[27]  E. Martens,et al.  Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier , 2018, Nature Reviews Microbiology.

[28]  Harry Sokol,et al.  Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease. , 2018, Cell host & microbe.

[29]  C. Hoffmann,et al.  The human gut microbiota: Metabolism and perspective in obesity , 2018, Gut microbes.

[30]  M. Cho,et al.  Immunological pathogenesis of inflammatory bowel disease , 2018, Intestinal research.

[31]  Michael Krawczak,et al.  Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases. , 2017, Gastroenterology.

[32]  T. Cullen,et al.  Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling , 2017, mSystems.

[33]  A. Basit,et al.  Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets. , 2016, Translational research : the journal of laboratory and clinical medicine.

[34]  E. Bézard,et al.  LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain. , 2016, Bioanalysis.

[35]  M. Balda,et al.  Tight junctions: from simple barriers to multifunctional molecular gates , 2016, Nature Reviews Molecular Cell Biology.

[36]  I. Amit,et al.  Host microbiota constantly control maturation and function of microglia in the CNS , 2015, Nature Neuroscience.

[37]  J. Sonnenburg,et al.  Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates. , 2014, Cell metabolism.

[38]  William W. Agace,et al.  Regional specialization within the intestinal immune system , 2014, Nature Reviews Immunology.

[39]  Judy H. Cho,et al.  Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease , 2014, Cell.

[40]  David Artis,et al.  Intestinal epithelial cells: regulators of barrier function and immune homeostasis , 2014, Nature Reviews Immunology.

[41]  P. Rosenstiel,et al.  ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation , 2012, Nature.

[42]  C. Elson,et al.  Host-microbiota interactions in inflammatory bowel disease , 2012, Gut microbes.

[43]  Liang Zhou,et al.  The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. , 2012, Immunity.

[44]  Natalie A. Roberts,et al.  Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation , 2011, Cell.

[45]  Fiona Powrie,et al.  Intestinal homeostasis and its breakdown in inflammatory bowel disease , 2011, Nature.

[46]  S. Massart,et al.  Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa , 2010, Proceedings of the National Academy of Sciences.

[47]  Jerrold R. Turner,et al.  Intestinal mucosal barrier function in health and disease , 2009, Nature Reviews Immunology.

[48]  Johan Auwerx,et al.  Targeting bile-acid signalling for metabolic diseases , 2008, Nature Reviews Drug Discovery.

[49]  B Havsteen,et al.  Flavonoids, a class of natural products of high pharmacological potency. , 1983, Biochemical pharmacology.

[50]  M. Talamini,et al.  Ulcerative colitis , 2012, The Lancet.