An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes

[1]  I. Shapiro,et al.  Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB. , 2013, The American journal of pathology.

[2]  I. Shapiro,et al.  Inflammatory Cytokines Induce NOTCH Signaling in Nucleus Pulposus Cells , 2013, The Journal of Biological Chemistry.

[3]  I. Shapiro,et al.  Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. , 2013, Arthritis and rheumatism.

[4]  D. Sakai,et al.  Homing of Mesenchymal Stem Cells in Induced Degenerative Intervertebral Discs in a Whole Organ Culture System , 2012, Spine.

[5]  Y. Toyama,et al.  Prolyl Hydroxylase 3 (PHD3) Modulates Catabolic Effects of Tumor Necrosis Factor-α (TNF-α) on Cells of the Nucleus Pulposus through Co-activation of Nuclear Factor κB (NF-κB)/p65 Signaling* , 2012, The Journal of Biological Chemistry.

[6]  J. Niinimäki,et al.  Does Lumbar Disc Degeneration on Magnetic Resonance Imaging Associate With Low Back Symptom Severity in Young Finnish Adults? , 2011, Spine.

[7]  T. Albert,et al.  An organ culture system to model early degenerative changes of the intervertebral disc , 2011, Arthritis research & therapy.

[8]  T. Steffen,et al.  Development of an Organ Culture System for Long-Term Survival of the Intact Human Intervertebral Disc , 2011, Spine.

[9]  H. Gruber,et al.  Variations in aggrecan localization and gene expression patterns characterize increasing stages of human intervertebral disk degeneration. , 2011, Experimental and molecular pathology.

[10]  S. Hollister,et al.  Time course investigation of intervertebral disc degeneration produced by needle-stab injury of the rat caudal spine: laboratory investigation. , 2011, Journal of neurosurgery. Spine.

[11]  I. Shapiro,et al.  TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc* , 2011, The Journal of Biological Chemistry.

[12]  Safdar N. Khan,et al.  Mechanical Deformation and Glycosaminoglycan Content Changes in a Rabbit Annular Puncture Disc Degeneration Model , 2011, Spine.

[13]  James D. Kang,et al.  Human Nucleus Pulposus Cells React to IL-6: Independent Actions and Amplification of Response to IL-1 and TNF-&agr; , 2011, Spine.

[14]  T. Steffen,et al.  Development of an intact intervertebral disc organ culture system in which degeneration can be induced as a prelude to studying repair potential , 2011, European Spine Journal.

[15]  Laura S. Stone,et al.  Behavioral Signs of Chronic Back Pain in the SPARC-Null Mouse , 2011, Spine.

[16]  Keita Ito,et al.  The Combined Effects of Limited Nutrition and High-Frequency Loading on Intervertebral Discs With Endplates , 2010, Spine.

[17]  Simon C Watkins,et al.  Accelerated aging of intervertebral discs in a mouse model of progeria , 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[18]  A. Tricco,et al.  Synthesis of recommendations for the assessment and management of low back pain from recent clinical practice guidelines. , 2010, The spine journal : official journal of the North American Spine Society.

[19]  K. Cheung,et al.  Cryopreserved intervertebral disc with injected bone marrow-derived stromal cells: a feasibility study using organ culture. , 2010, The spine journal : official journal of the North American Spine Society.

[20]  T. Vos,et al.  Measuring the global burden of low back pain. , 2010, Best practice & research. Clinical rheumatology.

[21]  Xiong Guo,et al.  Gene expression profiles of disc tissues and peripheral blood mononuclear cells from patients with degenerative discs , 2010, Journal of Bone and Mineral Metabolism.

[22]  P. Fortina,et al.  Reversine enhances generation of progenitor-like cells by dedifferentiation of annulus fibrosus cells. , 2010, Tissue engineering. Part A.

[23]  H. Wilke,et al.  A New Porcine In Vivo Animal Model of Disc Degeneration: Response of Anulus Fibrosus Cells, Chondrocyte-Like Nucleus Pulposus Cells, and Notochordal Nucleus Pulposus Cells to Partial Nucleotomy , 2009, Spine.

[24]  S. Yamasaki,et al.  Proinflammatory Cytokines Synergistically Enhance the Production of Chemokine Ligand 20 (CCL20) from Rheumatoid Fibroblast-like Synovial Cells in vitro and Serum CCL20 Is Reduced in vivo by Biologic Disease-modifying Antirheumatic Drugs , 2009, The Journal of Rheumatology.

[25]  Wei-Hong Chen,et al.  Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma. , 2009, Biomaterials.

[26]  Takashi Nakamura,et al.  CCL20 produced in the cytokine network of rheumatoid arthritis recruits CCR6+ mononuclear cells and enhances the production of IL-6. , 2009, Cytokine.

[27]  Xue-jun Cui,et al.  A Continuous Observation of the Degenerative Process in the Intervertebral Disc of Smad3 Gene Knock-Out Mice , 2009, Spine.

[28]  N. Boos,et al.  Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration , 2009, European Spine Journal.

[29]  S. Goldstein,et al.  Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture. , 2009, Journal of neurosurgery. Spine.

[30]  Keita Ito,et al.  Effect of Limited Nutrition on In Situ Intervertebral Disc Cells Under Simulated-Physiological Loading , 2009, Spine.

[31]  A. Freemont,et al.  Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration , 2009, Arthritis research & therapy.

[32]  Yubo Sun,et al.  Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc , 2009, Arthritis research & therapy.

[33]  A. Freemont,et al.  Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration. , 2009, Arthritis and rheumatism.

[34]  Koichi Masuda,et al.  Age-Related Changes in the Extracellular Matrix of Nucleus Pulposus and Anulus Fibrosus of Human Intervertebral Disc , 2009, Spine.

[35]  R. Ching,et al.  Intervertebral disc degeneration in a naturally occurring primate model: Radiographic and biomechanical evidence , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[36]  A. Freemont,et al.  Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc , 2008, Arthritis research & therapy.

[37]  Bin Han,et al.  A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail , 2008, Spine.

[38]  J. Iatridis,et al.  Dynamic Compression Effects on Intervertebral Disc Mechanics and Biology , 2008, Spine.

[39]  H. Gruber,et al.  Analysis of cell death and vertebral end plate bone mineral density in the annulus of the aging sand rat. , 2008, The spine journal : official journal of the North American Spine Society.

[40]  Jeffrey C. Wang,et al.  A porcine model of intervertebral disc degeneration induced by annular injury characterized with magnetic resonance imaging and histopathological findings. Laboratory investigation. , 2008, Journal of neurosurgery. Spine.

[41]  T. Smit,et al.  Reproducible Long-term Disc Degeneration in a Large Animal Model , 2008, Spine.

[42]  P. Sham,et al.  Association of the asporin D14 allele with lumbar-disc degeneration in Asians. , 2008, American journal of human genetics.

[43]  J. Urban,et al.  Bovine explant model of degeneration of the intervertebral disc , 2008, BMC musculoskeletal disorders.

[44]  S. Surrey,et al.  Heterozygous disruption of Flk-1 receptor leads to myocardial ischaemia reperfusion injury in mice: application of affymetrix gene chip analysis , 2008, Journal of cellular and molecular medicine.

[45]  J. Costi,et al.  Needle Puncture Injury Affects Intervertebral Disc Mechanics and Biology in an Organ Culture Model , 2008, Spine.

[46]  Sounok Sen,et al.  An In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc , 2008, Spine.

[47]  L. Dai,et al.  The cell biology of intervertebral disc aging and degeneration , 2007, Ageing Research Reviews.

[48]  A. Freemont,et al.  Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile , 2007, Arthritis research & therapy.

[49]  V. Podichetty The aging spine: the role of inflammatory mediators in intervertebral disc degeneration. , 2007, Cellular and molecular biology.

[50]  A. Freemont,et al.  Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration , 2007, Arthritis research & therapy.

[51]  H. Gruber,et al.  Microarray Analysis of Laser Capture Microdissected-Anulus Cells From the Human Intervertebral Disc , 2007, Spine.

[52]  B. Peng,et al.  A New In Vivo Animal Model to Create Intervertebral Disc Degeneration Characterized by MRI, Radiography, CT/Discogram, Biochemistry, and Histology , 2007, Spine.

[53]  L. Nolte,et al.  Establishment of a Novel Intervertebral Disc/Endplate Culture Model: Analysis of an Ex Vivo In Vitro Whole-Organ Rabbit Culture System , 2006, Spine.

[54]  V. Denaro,et al.  Toward an Optimum System for Intervertebral Disc Organ Culture: TGF-β3 Enhances Nucleus Pulposus and Anulus Fibrosus Survival and Function Through Modulation of TGF-β-R Expression and ERK Signaling , 2006, Spine.

[55]  J. Katz,et al.  Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. , 2006, The Journal of bone and joint surgery. American volume.

[56]  H. An,et al.  Animal models for human disc degeneration. , 2005, The spine journal : official journal of the North American Spine Society.

[57]  P. Roughley,et al.  Tumor Necrosis Factor&agr; Modulates Matrix Production and Catabolism in Nucleus Pulposus Tissue , 2005, Spine.

[58]  A. Freemont,et al.  The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration , 2005, Arthritis research & therapy.

[59]  Koichi Masuda,et al.  A Novel Rabbit Model of Mild, Reproducible Disc Degeneration by an Anulus Needle Puncture: Correlation Between the Degree of Disc Injury and Radiological and Histological Appearances of Disc Degeneration , 2005, Spine.

[60]  A. Freemont,et al.  Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc , 2004, The Journal of pathology.

[61]  T. Albert,et al.  An Organ Culture System for the Study of the Nucleus Pulposus: Description of the System and Evaluation of the Cells , 2003, Spine.

[62]  G. Balian,et al.  A Fibronectin Fragment Stimulates Intervertebral Disc Degeneration In Vivo , 2003, Spine.

[63]  A. Nerlich,et al.  New In Vivo Animal Model to Create Intervertebral Disc Degeneration and to Investigate the Effects of Therapeutic Strategies to Stimulate Disc Regeneration , 2002, Spine.

[64]  D. Hukins,et al.  Sheep lumbar intervertebral discs as models for human discs. , 2002, Clinical biomechanics.

[65]  J. Fitzpatrick,et al.  Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. , 2002, The Journal of bone and joint surgery. British volume.

[66]  F. Greco,et al.  Cytokines and growth factors in the protruded intervertebral disc of the lumbar spine , 2002, European Spine Journal.

[67]  C. Pfirrmann,et al.  Magnetic Resonance Classification of Lumbar Intervertebral Disc Degeneration , 2001, Spine.

[68]  E Viikari-Juntura,et al.  Low back pain in relation to lumbar disc degeneration. , 2000, Spine.

[69]  N. Bogduk,et al.  The Relative Contributions of the Disc and Zygapophyseal Joint in Chronic Low Back Pain , 1994, Spine.

[70]  R. Moskowitz,et al.  Spondylosis in sand rats: A model of intervertebral disc degeneration and hyperostosis , 1990, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[71]  J. P. Thompson,et al.  Preliminary Evaluation of a Scheme for Grading the Gross Morphology of the Human Intervertebral Disc , 1990, Spine.

[72]  Nicholas,et al.  Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. , 1990, The Journal of bone and joint surgery. American volume.

[73]  F. Shen,et al.  Therapeutic effects of adenovirus-mediated growth and differentiation factor-5 in a mice disc degeneration model induced by annulus needle puncture. , 2010, The spine journal : official journal of the North American Spine Society.

[74]  L. Setton,et al.  Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen. , 2008, Arthritis and rheumatism.

[75]  J. Ralphs,et al.  Are animal models useful for studying human disc disorders/degeneration? , 2007, European Spine Journal.

[76]  S D Kuslich,et al.  The tissue origin of low back pain and sciatica: a report of pain response to tissue stimulation during operations on the lumbar spine using local anesthesia. , 1991, The Orthopedic clinics of North America.