A New Metoclopramide Potentiometric Membrane Sensor for Analysis in Pharmaceutical Formulation and Urine: Concerns to Theoretical Study

methoxy benzamide, is usually marketed as the hydrochloride salt is a potent dopamine receptor antagonist used for its antiemetic and prokinetic properties. In this study, a potentiometric liquid membrane sensor for simple and fast determination of metoclopramide hydrochloride in pharmaceutical formulation and urine were constructed. Since Computational chemistry and molecular modeling play an important role in the modern drug discovery, after some theoretical calculations metoclopramide-tetraphenyl borate complex was used as electroactive material in the membrane preparation. The wide linear range (10