Cellular Senescence Minireview Mitotic Clock or Culture Shock?

Department of Tumor Cell Biology with a high degree of probability for each independent St. Jude Children’s Research Hospital embryo-derived culture) and give rise to established Memphis, Tennessee 38105 “3T3 cell lines.” These cells have an increased growth †Department of Adult Oncology rate and a greater ability to proliferate at low density Dana Farber Cancer Institute and than early-passage MEF strains. The vast majority Departments of Genetics and Medicine (z80%) are hypotetraploid and contain mutant p53 alHarvard Medical School leles, whereas most others sustain biallelic loss of the Boston, Massachusetts 02115 INK4a/ARF locus and remain pseudodiploid. The rea-

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