EchoCP: An Echocardiography Dataset in Contrast Transthoracic Echocardiography for Patent Foramen Ovale Diagnosis

Patent foramen ovale (PFO) is a potential separation between the septum, primum and septum secundum located in the anterosuperior portion of the atrial septum. PFO is one of the main factors causing cryptogenic stroke which is the fifth leading cause of death in the United States. For PFO diagnosis, contrast transthoracic echocardiography (cTTE) is preferred as being a more robust method compared with others. However, the current PFO diagnosis through cTTE is extremely slow as it is proceeded manually by sonographers on echocardiography videos. Currently there is no publicly available dataset for this important topic in the community. In this paper, we present EchoCP, as the first echocardiography dataset in cTTE targeting PFO diagnosis. EchoCP consists of 30 patients with both rest and Valsalva maneuver videos which covers various PFO grades. We further establish an automated baseline method for PFO diagnosis based on the state-of-the-art cardiac chamber segmentation technique, which achieves 0.89 average mean Dice score, but only 0.60/0.67 mean accuracies for PFO diagnosis, leaving large room for improvement. We hope that the challenging EchoCP dataset can stimulate further research and lead to innovative and generic solutions that would have an impact in multiple domains. Our dataset is released [1].

[1]  J. Somerville,et al.  Contrast echocardiography for diagnosis of pulmonary arteriovenous fistulas late after construction of a Glenn anastomosis , 1998, Cardiology in the Young.

[2]  Chen Wang,et al.  Standardized Evaluation System for Left Ventricular Segmentation Algorithms in 3D Echocardiography , 2016, IEEE Transactions on Medical Imaging.

[3]  Jinjun Xiong,et al.  MSU-Net: Multiscale Statistical U-Net for Real-time 3D Cardiac MRI Video Segmentation , 2019, MICCAI.

[4]  Jean-Marc Schleich,et al.  Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke , 2017, The New England journal of medicine.

[5]  J. Tobis,et al.  The effect of patent foramen ovale closure on visual aura without headache or typical aura with migraine headache. , 2012, JACC. Cardiovascular interventions.

[6]  Klaus H. Maier-Hein,et al.  Automated Design of Deep Learning Methods for Biomedical Image Segmentation , 2019 .

[7]  Jian Zhuang,et al.  ImageCHD: A 3D Computed Tomography Image Dataset for Classification of Congenital Heart Disease , 2020, MICCAI.

[8]  David E. Thaler,et al.  Long‐Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke , 2017, The New England journal of medicine.

[9]  G. Lip,et al.  Patent foramen ovale and migraine attacks: a systematic review. , 2014, The American journal of medicine.

[10]  A. Padovani,et al.  Low cerebrovascular event rate in subjects with patent foramen ovale and different clinical presentations: results from a prospective non randomized study on a population including patients with and without patent foramen ovale closure. , 2012, International journal of cardiology.

[11]  Curtis P. Langlotz,et al.  Video-based AI for beat-to-beat assessment of cardiac function , 2020, Nature.

[12]  Frederic Cervenansky,et al.  Deep Learning for Segmentation Using an Open Large-Scale Dataset in 2D Echocardiography , 2019, IEEE Transactions on Medical Imaging.

[13]  J. Tobis,et al.  Prevalence of migraine headaches in patients with congenital heart disease. , 2008, The American journal of cardiology.

[14]  Jimmy Ba,et al.  Adam: A Method for Stochastic Optimization , 2014, ICLR.

[15]  W. Edwards,et al.  Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts. , 1984, Mayo Clinic proceedings.

[16]  J. Tobis,et al.  PFO and paradoxical embolism producing events other than stroke , 2011, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[17]  Giorgio Ferriero,et al.  Migraine with Aura and Right-to-Left Shunt on Transcranial Doppler: A Case-Control Study , 1998, Cerebrovascular Diseases.

[18]  M. Schwerzmann,et al.  Risk of decompression illness among 230 divers in relation to the presence and size of patent foramen ovale. , 2004, European heart journal.

[19]  Yajuan Du,et al.  Modified Method of Contrast Transthoracic Echocardiography for the Diagnosis of Patent Foramen Ovale , 2019, BioMed research international.

[20]  Jinjun Xiong,et al.  ICA-UNet: ICA Inspired Statistical UNet for Real-time 3D Cardiac Cine MRI Segmentation , 2020, MICCAI.

[21]  Seyed-Ahmad Ahmadi,et al.  V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation , 2016, 2016 Fourth International Conference on 3D Vision (3DV).