Metabolic dysregulation in the SHROB rat reflects abnormal expression of transcription factors and enzymes that regulate carbohydrate metabolism.
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P. Ernsberger | F. Bone | D. Massillon | I. Arinze | Tertius T Tuy | Janean Johnson | Chuan Xu | Frederic Bone
[1] J. Holloszy,et al. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. , 2005, Cell metabolism.
[2] Shwu‐Yuan Wu,et al. SREBP-1c and Sp1 Interact to Regulate Transcription of the Gene for Phosphoenolpyruvate Carboxykinase (GTP) in the Liver* , 2004, Journal of Biological Chemistry.
[3] F. Bone,et al. Regulation of Glucose-6-phosphatase Gene Expression in Cultured Hepatocytes and H4IIE Cells by Short-chain Fatty Acids , 2003, Journal of Biological Chemistry.
[4] R. Knutsen,et al. Dexamethasone induction of hypertension and diabetes is PPAR-α dependent in LDL receptor–null mice , 2003, Nature Medicine.
[5] J. K. Oeser,et al. Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells. , 2003, The Biochemical journal.
[6] F. Gonzalez,et al. Defective Ureagenesis in Mice Carrying a Liver-specific Disruption of Hepatocyte Nuclear Factor 4α (HNF4α) , 2002, The Journal of Biological Chemistry.
[7] P. Ernsberger,et al. Plasma Glucagon and Free Fatty Acid Responses to a Glucose Load in the Obese Spontaneous Hypertensive Rat (SHROB) Model of Metabolic Syndrome X , 2002, Experimental biology and medicine.
[8] J. Berger,et al. The mechanisms of action of PPARs. , 2002, Annual review of medicine.
[9] G. Reach,et al. PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance , 2001 .
[10] M. Foretz,et al. Sterol Regulatory Element-binding Protein-1c Mimics the Negative Effect of Insulin on Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription* , 2001, The Journal of Biological Chemistry.
[11] Marc Montminy,et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 , 2001, Nature.
[12] Guillaume Adelmant,et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 , 2001, Nature.
[13] D. Massillon. Regulation of the Glucose-6-phosphatase Gene by Glucose Occurs by Transcriptional and Post-transcriptional Mechanisms , 2001, The Journal of Biological Chemistry.
[14] Jerrold M. Ward,et al. Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis , 2001, Molecular and Cellular Biology.
[15] V. Poli,et al. Mice with a Deletion in the Gene for CCAAT/Enhancer-binding Protein β Have an Attenuated Response to cAMP and Impaired Carbohydrate Metabolism* , 2001, The Journal of Biological Chemistry.
[16] W. Roesler,et al. The role of C/EBP in nutrient and hormonal regulation of gene expression. , 2001, Annual review of nutrition.
[17] P. Ernsberger,et al. Molecular Pathology in the Obese Spontaneous Hypertensive Koletsky Rat: A Model of Syndrome X , 1999, Annals of the New York Academy of Sciences.
[18] M. Roden,et al. Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver , 1999, Hepatology.
[19] P. Ernsberger,et al. Phenotypic consequences of a nonsense mutation in the leptin receptor gene (fak) in obese spontaneously hypertensive Koletsky rats (SHROB). , 1998, The Journal of nutrition.
[20] J. Peters,et al. Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)* , 1998, The Journal of Biological Chemistry.
[21] N. Barzilai,et al. Short Term Effects of Leptin on Hepatic Gluconeogenesis and in Vivo Insulin Action* , 1997, The Journal of Biological Chemistry.
[22] J. Beavo,et al. Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[23] M. Nicolson,et al. Phenotype of the Obese Koletsky (f) Rat Due to Tyr763Stop Mutation in the Extracellular Domain of the Leptin Receptor (Lepr): Evidence for Deficient Plasma-to-CSF Transport of Leptin in Both the Zucker and Koletsky Obese Rat , 1997, Diabetes.
[24] R. Hanson,et al. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. , 1997, Annual review of biochemistry.
[25] K. Nakao,et al. Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat , 1996, Nature Genetics.
[26] G. Reaven,et al. Pathophysiology of insulin resistance in human disease. , 1995, Physiological reviews.
[27] P. Ernsberger,et al. Synthesis, binding properties, and 18F labeling of fluorocarazolol, a high-affinity beta-adrenergic receptor antagonist. , 1994, Journal of medicinal chemistry.
[28] E. Degerman,et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[29] G. Reaven. Role of Insulin Resistance in Human Disease , 1988, Diabetes.
[30] G. Reaven,et al. Evidence of abnormalities of insulin metabolism in rats with spontaneous hypertension. , 1988, Metabolism: clinical and experimental.
[31] A. Newman,et al. Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand. , 1987, The Journal of biological chemistry.
[32] M. Bollen,et al. An assessment of the importance of intralysosomal and of alpha-amylolytic glycogenolysis in the liver of normal rats and of rats with a glycogen-storage disease. , 1985, European journal of biochemistry.