A Comparative Study of Coagulation and Fibrinolysis in Blood from Normal Men and Women

It is well known that several coagulation factors increase in concentration in the blood during pregnancy (Pechet and Alexander, 1961; Kasper, Hogg, Aggeler and Stone, 1964), and changes in the fibrinolytic system have also been described (Brakman and Astrup, 1963). Some coagulation factors and components of the fibrinolytic system are reported to be influenced by male and female hormones (Tagnon, Schulman, Whitmore and Leons, 1953). Mixtures of progestational and oestrogenic hormones influence coagulation and fibrinolysis in blood (Brakman and Astrup, 1964a; Hougie, Rutherford, Banks and Coburn, 1965). An increase in fibrinolytic activity of the circulating blood during menstruation has been reported by some authors, though others have been unable to confirm this. It is often difficult to evaluate these results because inaccurate or insensitive assay methods have been used. The present paper attempts to establish carefully assayed, normal values of certain parameters of blood coagulation and fibrinolysis in peripheral blood from men and women in order to compare them and to elucidate their possible fluctuations during menstruation. Such data are needed for establishing the normal patterns of coagulation and fibrinolysis, and in order to evaluate the possible influence of male and female hormones on these patterns. The present report provides a baseline for further studies of coagulation and fibrinolysis in blood.

[1]  C. Hougie,et al.  EFFECT OF A PROGESTIN-ESTROGEN ORAL CONTRACEPTIVE ON BLOOD CLOTTING FACTORS. , 1965, Metabolism: clinical and experimental.

[2]  A. Rao.  PLASMA FIBRINOLYTIC ACTIVITY AND MENSTRUAL CYCLE IN WOMEN , 1964 .

[3]  S. Stone,et al.  Blood Clotting Factors in Pregnancy: Factor VIII Concentrations in Normal and AHF‐deficient Women , 1964 .

[4]  T. Astrup,et al.  EFFECTS OF FEMALE HORMONES, USED AS ORAL CONTRACEPTIVES, ON THE FIBRINOLYTIC SYSTEM IN BLOOD. , 1964, Lancet.

[5]  U. Goebelsmann,et al.  The Fibrinolytic System During the Menstrual Cycle , 1964, Obstetrics and gynecology.

[6]  Sortor Rf.  ESTROGENS AND BLEEDING TIMES IN PSEUDOHEMOPHILIA A. , 1963 .

[7]  P. Owren,et al.  Oral Contraception and Blood Coagulability , 1963, British medical journal.

[8]  K. Brinkhous,et al.  THE PARTIAL THROMBOPLASTIN TIME AS A SCREENING TEST FOR THE DETECTION OF LATENT BLEEDERS , 1962, The American journal of the medical sciences.

[9]  R. Turksoy,et al.  Influence of ovarian function on the fibrinolytic enzyme system. II. Influence of exogenous steroids. , 1961, American journal of obstetrics and gynecology.

[10]  L. Pechet,et al.  Increased clotting factors in pregnacy. , 1961, The New England journal of medicine.

[11]  P. Ollendorff.  Improvements in the Thrombin Generation Test , 1960, Thrombosis and Haemostasis.

[12]  S. Lindsay,et al.  Elevation of Platelets in Mid-Cycle: an Indication of Ovulation , 1956 .

[13]  W. Whitmore,et al.  Prostatic fibrinolysin; study of a case illustrating role in hemorrhagic diathesis of cancer of the prostate. , 1953, The American journal of medicine.

[14]  T. Astrup,et al.  The fibrin plate method for estimating fibrinolytic activity. , 1952, Archives of biochemistry and biophysics.

[15]  O. Ratnoff,et al.  A new method for the determination of fibrinogen in small samples of plasma. , 1951, The Journal of laboratory and clinical medicine.

[16]  Grossman Bj,et al.  Observations on the clotting mechanism in menstruation and menorrhagia. , 1949 .

[17]  R. G. Macfarlane,et al.  Observations on fibrinolysis; spontaneous activity associated with surgical operations, trauma, & c. , 1946, Lancet.

[18]  E. Munnell,et al.  Fibrinolytic Activity in Blood Serum During Pregnancy Complicated by Hypertensive Toxemias , 1946, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[19]  O. Smith,et al.  A FIBRINOLYTIC ENZYME IN MENSTRUATION AND LATE PREGNANCY TOXEMIA. , 1945, Science.

[20]  F. Pohle.  THE BLOOD PLATELET COUNT IN RELATION TO THE MENSTRUAL CYCLE IN NORMAL WOMEN , 1939 .

[21]  W. Dameshek.  A METHOD FOR THE SIMULTANEOUS ENUMERATION OF BLOOD PLATELETS AND RETICULOCYTES: WITH CONSIDERATION OF THE NORMAL BLOOD PLATELET COUNT IN MEN AND IN WOMEN , 1932 .

[22]  T. Astrup,et al.  THE ESTIMATION OF FIBRINOGEN. A REVISION. , 1965, Scandinavian journal of clinical and laboratory investigation.

[23]  T. Astrup,et al.  FIBRINOLYTIC ACTIVITY IN HUMAN BLOOD ASSAYED IN A PEPTONE-LIKE SYSTEM. , 1964, Sangre.

[24]  T. Astrup,et al.  SELECTIVE INHIBITION IN HUMAN PREGNANCY BLOOD OF UROKINASE INDUCED FIBRINOLYSIS. , 1963, Scandinavian journal of clinical and laboratory investigation.

[25]  R. Turksoy,et al.  Influence of ovarian function on the fibrinolytic enzyme system. I. Ovulatory and anovulatory cycles. , 1961, American journal of obstetrics and gynecology.

[26]  T. Astrup,et al.  Estimation of thromboplastin activation in plasma. , 1961, Scandinavian journal of clinical and laboratory investigation.

[27]  J. Dausset,et al.  Fibrinolyse du sang péripheriquè au cours du flux menstruel physiologique. , 1958 .

[28]  T. Astrup,et al.  Estimation of the plasminogen activator and the trypsin inhibitor in animal and human tissues. , 1957, Scandinavian journal of clinical and laboratory investigation.

[29]  B. Rovatti,et al.  [Studies on fibrinolysis during the menstrual cycle]. , 1952, Haematologica.

[30]  P. Owren,et al.  The control of dicumarol therapy and the quantitative determination of prothrombin and proconvertin. , 1951, Scandinavian journal of clinical and laboratory investigation.