Blood levels of catecholamine metabolites and brain-derived neurotrophic factor in a case of Sydenham's chorea

We report a case of Sydenham's chorea with neuropsychiatric symptoms who was successfully treated with low-dose risperidone. We also longitudinally investigated serum BDNF levels and plasma levels of catecholamine metabolite in the patient. Serum BDNF levels were increased and plasma levels of HVA and MHPG were decreased according to the recovery from the active phase of the disease. These results suggest that dysfunctions of catecholaminergic neurons and neurotrophic factors might exist in Sydenham's chorea, and the decreasing catecholamine activities in response to risperidone might be associated with the improvement of the disease.

[1]  Frank Seifert,et al.  Correlation Between Serum Brain-Derived Neurotrophic Factor Level and An In Vivo Marker of Cortical Integrity , 2007, Biological Psychiatry.

[2]  T. Shinkai,et al.  Treatment with risperidone for 4 weeks increased plasma 3-methoxy-4-hydroxypnenylglycol (MHPG) levels, but did not alter plasma brain-derived neurotrophic factor (BDNF) levels in schizophrenic patients , 2007, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[3]  A. Teixeira,et al.  Psychosis following acute Sydenham’s chorea , 2007, European Child & Adolescent Psychiatry.

[4]  R. Yoshimura,et al.  Effect of risperidone on plasma catecholamine metabolites and brain‐derived neurotrophic factor in patients with bipolar disorders , 2006, Human psychopharmacology.

[5]  R. Yoshimura,et al.  An open study of risperidone liquid in the acute phase of schizophrenia , 2005, Human psychopharmacology.

[6]  R. Yoshimura,et al.  Clinical response to antidepressant treatment and 3-methoxy-4-hydroxyphenylglycol levels: mini review , 2004, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[7]  A. Spissu,et al.  Treatment of Sydenham's chorea with a combination of l-Dopa and a peripheral Dopa decarboxylase inhibitor , 1975, Psychopharmacologia.

[8]  A. Teixeira,et al.  Sydenham’s chorea may be a risk factor for drug induced parkinsonism , 2003, Journal of neurology, neurosurgery, and psychiatry.

[9]  M. Schwald,et al.  Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets , 2002, Neuroscience Letters.

[10]  O. Molina,et al.  Comparison of the efficacy of carbamazepine, haloperidol and valproic acid in the treatment of children with Sydenham's chorea: clinical follow-up of 18 patients. , 2002, Arquivos de neuro-psiquiatria.

[11]  B. Şaylan,et al.  Sydenham's chorea: clinical findings and comparison of the efficacies of sodium valproate and carbamazepine regimens , 2002, Brain and Development.

[12]  William A Banks,et al.  Transport of brain-derived neurotrophic factor across the blood–brain barrier , 1998, Neuropharmacology.

[13]  D. Moore.  Neuropsychiatric aspects of Sydenham's chorea: a comprehensive review. , 1996, The Journal of clinical psychiatry.

[14]  S. Naidu,et al.  Sydenham's chorea: A possible presynaptic dopaminergic dysfunction initially , 1980, Annals of Neurology.

[15]  S. Lal,et al.  Dopaminergic function in gilles de la tourette's syndrome, sydenham's chorea and torsion dystonia , 1976, Clinical Neurology and Neurosurgery.

[16]  J. Freeman,et al.  THE NATURAL HISTORY OF SYDENHAM'S CHOREA. REVIEW OF THE LITERATURE AND LONG-TERM EVALUATION WITH EMPHASIS ON CARDIAC SEQUELAE. , 1965, The American journal of medicine.

[17]  W. L. Bruetsch.  LATE CEREBRAL SEQUELAE OF RHEUMATIC FEVER , 1944 .