Data Reconciliation of Release Mechanism Research of LDH-Based Drug

Sebacate pillared layered double hydroxides (LDH) was prepared via co-precipitation method. And then the drug 10-hydroxy-camptothecin (10-HC) was intercalated into the gallery of LDH to form the drug–LDH composites. Three types of dissolution- diffusion kinetics models were used to make clear the drug release mechanism of the LDH composites. For the first time data reconciliation was used to make clear the drug release kinetics mechanism of the LDH composites, which was carried out by using a data filter algorithm based on first-order delay filter and time-delay principle to diminish random experimental errors resulting from the factors including stirring speed, solid content, and so on. Simulation results indicated that the data reconciliation adequately degraded the interactions between drug release rates at different times and made the data satisfy the kinetics models for the drug release mechanism more accurately.