Mutation of the Angelman Ubiquitin Ligase in Mice Causes Increased Cytoplasmic p53 and Deficits of Contextual Learning and Long-Term Potentiation

[1]  J. Bressler,et al.  Imprinting in Angelman and Prader-Willi syndromes. , 1998, Current opinion in genetics & development.

[2]  R. Olsen,et al.  Angelman syndrome: Correlations between epilepsy phenotypes and genotypes , 1998, Annals of neurology.

[3]  Ken Chen,et al.  The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53 , 1998, Cell.

[4]  A. Ciechanover,et al.  The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[5]  P. Howley,et al.  The Role of E6AP in the Regulation of p53 Protein Levels in Human Papillomavirus (HPV)-positive and HPV-negative Cells* , 1998, The Journal of Biological Chemistry.

[6]  P. Daniels,et al.  Characterization of the interactions of human papillomavirus type 16 E6 with p53 and E6-associated protein in insect and human cells. , 1998, The Journal of general virology.

[7]  Wolfgang Baumeister,et al.  The Proteasome: Paradigm of a Self-Compartmentalizing Protease , 1998, Cell.

[8]  N. Copeland,et al.  The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice , 1998, Nature Genetics.

[9]  C. Stevens,et al.  A Million Dollar Question: Does LTP = Memory? , 1998, Neuron.

[10]  Michael Davis,et al.  Evidence of Contextual Fear after Lesions of the Hippocampus: A Disruption of Freezing But Not Fear-Potentiated Startle , 1997, The Journal of Neuroscience.

[11]  H. Zoghbi,et al.  Purkinje Cell Expression of a Mutant Allele of SCA1in Transgenic Mice Leads to Disparate Effects on Motor Behaviors, Followed by a Progressive Cerebellar Dysfunction and Histological Alterations , 1997, The Journal of Neuroscience.

[12]  A. Hoffman,et al.  Imprinting of the Angelman syndrome gene, UBE3A, is restricted to brain , 1997, Nature Genetics.

[13]  J. Sutcliffe,et al.  Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons , 1997, Nature Genetics.

[14]  C. Rougeulle,et al.  The Angelman syndrome candidate gene, UBE3AIE6-AP, is imprinted in brain , 1997, Nature Genetics.

[15]  J. Piette,et al.  Mdm2: keeping p53 under control , 1997, Oncogene.

[16]  T. Soderling,et al.  Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. , 1997, Science.

[17]  J. P. Jensen,et al.  Subcellular Localization and Ubiquitin-conjugating Enzyme (E2) Interactions of Mammalian HECT Family Ubiquitin Protein Ligases* , 1997, The Journal of Biological Chemistry.

[18]  P. Howley,et al.  Physical Interaction between Specific E2 and Hect E3 Enzymes Determines Functional Cooperativity* , 1997, The Journal of Biological Chemistry.

[19]  Stephen N. Jones,et al.  Regulation of p53 stability by Mdm2 , 1997, Nature.

[20]  M. Oren,et al.  Mdm2 promotes the rapid degradation of p53 , 1997, Nature.

[21]  P. Howley,et al.  The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing. , 1997, Genomics.

[22]  James H. Schwartz,et al.  Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia , 1997, Cell.

[23]  D. J. Driscoll,et al.  Genomic imprinting: potential function and mechanisms revealed by the Prader-Willi and Angelman syndromes. , 1997, Molecular human reproduction.

[24]  P. Beer-Romero,et al.  Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells , 1997, Oncogene.

[25]  B. Horsthemke,et al.  Imprinting mutations on human chromosome 15 , 1997, Human mutation.

[26]  Ping Fang,et al.  De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome , 1997, Nature Genetics.

[27]  M. Lalande,et al.  UBE3A/E6-AP mutations cause Angelman syndrome , 1996, Nature Genetics.

[28]  M. Bartolomei,et al.  Genomic imprinting in mammals. , 1997, Annual review of genetics.

[29]  J. Sweatt,et al.  Transient Activation of Cyclic AMP-dependent Protein Kinase during Hippocampal Long-term Potentiation* , 1996, The Journal of Biological Chemistry.

[30]  R. Jaenisch,et al.  Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[31]  J. Schein,et al.  An essential ubiquitin‐conjugating enzyme with tissue and developmental specificity in th nematode Caenorhabditis elegans. , 1996, EMBO Journal.

[32]  A. Beaudet,et al.  Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice , 1996, The Journal of experimental medicine.

[33]  C. Prives,et al.  p53: puzzle and paradigm. , 1996, Genes & development.

[34]  M. Hochstrasser,et al.  Protein Degradation or Regulation: Ub the Judge , 1996, Cell.

[35]  T. Maniatis,et al.  Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity , 1996, Cell.

[36]  Howard Riezman,et al.  Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis , 1996, Cell.

[37]  M. Hochstrasser.  Ubiquitin-dependent protein degradation. , 1996, Annual review of genetics.

[38]  M. Lalande.  Parental imprinting and human disease. , 1996, Annual review of genetics.

[39]  A. Ciechanover,et al.  Persistent activation of cAMP-dependent protein kinase by regulated proteolysis suggests a neuron-specific function of the ubiquitin system in Aplysia , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[40]  Bernhard Horsthemke,et al.  Inherited microdeletions in the Angelman and Prader–Willi syndromes define an imprinting centre on human chromosome 15 , 1995, Nature Genetics.

[41]  M. Scheffner,et al.  A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Eric R Kandel,et al.  A novel intermediate stage in the transition between short- and long-term facilitation in the sensory to motor neuron synapse of aplysia , 1995, Neuron.

[43]  Martin Scheffner,et al.  Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade , 1995, Nature.

[44]  H. Buckle,et al.  [Angelman syndrome]. , 2019, Nursing RSA = Verpleging RSA.

[45]  J. Sweatt,et al.  Autonomously active protein kinase C in the maintenance phase of N-methyl-D-aspartate receptor-independent long term potentiation. , 1994, The Journal of biological chemistry.

[46]  D. Ledbetter,et al.  Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region , 1994, Nature Genetics.

[47]  Y. Fukushima,et al.  Molecular and clinical study of 61 Angelman syndrome patients. , 1994, American journal of medical genetics.

[48]  S. Benzer,et al.  bendless, a Drosophila gene affecting neuronal connectivity, encodes a ubiquitin-conjugating enzyme homolog , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[49]  K. Tanaka,et al.  Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. , 1994, The EMBO journal.

[50]  D. Ledbetter,et al.  Imprinting analysis of three genes in the Prader-Willi/Angelman region: SNRPN, E6-associated protein, and PAR-2 (D15S225E). , 1994, Human molecular genetics.

[51]  M. Fanselow,et al.  Effects of amygdala, hippocampus, and periaqueductal gray lesions on short- and long-term contextual fear. , 1993, Behavioral neuroscience.

[52]  T. Sacktor,et al.  Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[53]  S. J. Chen,et al.  Mechanism of protein kinase C activation during the induction and maintenance of long-term potentiation probed using a selective peptide substrate. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[54]  D. Muller,et al.  Long-term potentiation is associated with an increased activity of Ca2+/calmodulin-dependent protein kinase II. , 1993, The Journal of biological chemistry.

[55]  M. Scheffner,et al.  Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53 , 1993, Molecular and cellular biology.

[56]  M. Fanselow,et al.  Modality-specific retrograde amnesia of fear. , 1992, Science.

[57]  James H. Schwartz,et al.  A regulatory subunit of the cAMP-dependent protein kinase down-regulated in aplysia sensory neurons during long-term sensitization , 1992, Neuron.

[58]  Joseph E LeDoux,et al.  Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. , 1992, Behavioral neuroscience.

[59]  S. J. Chen,et al.  Persistent protein kinase activation in the maintenance phase of long-term potentiation. , 1991, The Journal of biological chemistry.

[60]  M. Scheffner,et al.  A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. , 1991, The EMBO journal.

[61]  V. Rotter,et al.  Nuclear localization is essential for the activity of p53 protein. , 1991, Oncogene.

[62]  D. Johnston,et al.  N-methyl-D-aspartate receptor activation increases cAMP levels and voltage-gated Ca2+ channel activity in area CA1 of hippocampus. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[63]  V. Jay,et al.  Puppet‐like syndrome of Angelman , 1991, Neurology.

[64]  V. Rotter,et al.  Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells. , 1990, Oncogene.

[65]  E. Kandel,et al.  Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation ofAplysia sensory neurons , 1989, Nature.

[66]  E. Brett,et al.  The 'happy puppet' syndrome of Angelman: review of the clinical features. , 1989, Archives of disease in childhood.

[67]  H. Sambrook.  Molecular cloning : a laboratory manual. Cold Spring Harbor, NY , 1989 .

[68]  K. Hagino-Yamagishi,et al.  [Oncogene]. , 2019, Gan to kagaku ryoho. Cancer & chemotherapy.

[69]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[70]  D. MacGregor,et al.  The puppet-like syndrome of Angelman. , 1981, American journal of diseases of children.

[71]  E. Vicari.  Fatal Convulsive Seizures in the DBA Mouse Strain , 1951 .