MR ventilation‐perfusion imaging of human lung using oxygen‐enhanced and arterial spin labeling techniques

Magnetic resonance ventilation‐perfusion (V/Q) imaging has been demonstrated using oxygen and arterial spin labeling techniques. Inhaled oxygen is used as a paramagnetic contrast agent in ventilation imaging using a multiple inversion recovery (MIR) approach. Pulmonary perfusion imaging is conducted using a flow‐sensitive alternating inversion recovery with an extra radiofrequency pulse (FAIRER) technique. A half Fourier single‐short turbo spin echo (HASTE) sequence is used for data acquisition in both techniques. V/Q imaging was performed in ten of the twenty volunteers, while either ventilation or perfusion was imaged in the other ten. This V/Q imaging scheme is completely noninvasive, does not involve ionized radiation, and shows promising potential for clinical use in the diagnosis of lung diseases such as pulmonary embolism. J. Magn. Reson. Imaging 2001;14:574–579. © 2001 Wiley‐Liss, Inc.

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