Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
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Antonio Duarte | Gerhard Christofori | Seppo Ylä-Herttuala | M. Shibuya | K. Alitalo | C. Betsholtz | G. Christofori | P. Laakkonen | A. Eichmann | S. Ylä-Herttuala | H. Isoniemi | M. Hellström | G. Zarkada | T. Tammela | Reetta Peltonen | Masabumi Shibuya | Pirjo Laakkonen | Kari Alitalo | Tuomas Tammela | Christer Betsholtz | Mats Hellström | Steven Suchting | Anne Eichmann | B. Pytowski | Elisabet Wallgard | Aino Murtomäki | Elisabet Wallgard | T. Schomber | Catarina Freitas | Bronislaw Pytowski | Helena Isoniemi | Georgia Zarkada | Aino Murtomäki | Maria Wirzenius | Marika Waltari | Tibor Schomber | Reetta Peltonen | Maria Wirzenius | A. Duarte | S. Suchting | Catarina Freitas | M. Waltari | Pirjo Laakkonen | Marika Waltari
[1] M. Skobe,et al. Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. , 2007, The Journal of clinical investigation.
[2] R. Adams,et al. Regulation of vascular morphogenesis by Notch signaling. , 2007, Genes & development.
[3] M. Shibuya,et al. Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting , 2007, The Journal of experimental medicine.
[4] D. Hicklin,et al. Cooperative and redundant roles of VEGFR‐2 and VEGFR‐3 signaling in adult lymphangiogenesis , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[5] G. Thurston,et al. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting , 2007, Proceedings of the National Academy of Sciences.
[6] Antonio Duarte,et al. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching , 2007, Proceedings of the National Academy of Sciences.
[7] Nathan D. Lawson,et al. Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries , 2007, Nature.
[8] Holger Gerhardt,et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis , 2007, Nature.
[9] K. Alitalo,et al. Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth. , 2007, Cancer research.
[10] Minhong Yan,et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis , 2006, Nature.
[11] MasabumiShibuya,et al. Chimeric VEGF-ENZ7/PlGF Promotes Angiogenesis Via VEGFR-2 Without Significant Enhancement of Vascular Permeability and Inflammation , 2006 .
[12] T. Veikkola,et al. Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation. , 2006, The American journal of pathology.
[13] B. Weinstein,et al. Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[14] K. Alitalo,et al. Lymphangiogenesis and cancer metastasis. , 2006 .
[15] Gavin Thurston,et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. , 2006, Nature.
[16] Napoleone Ferrara,et al. Angiogenesis as a therapeutic target , 2005, Nature.
[17] Peter Carmeliet,et al. Angiogenesis in life, disease and medicine , 2005, Nature.
[18] Tatiana V. Petrova,et al. Lymphangiogenesis in development and human disease , 2005, Nature.
[19] K. Alitalo,et al. Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. , 2005, Blood.
[20] Seppo Ylä-Herttuala,et al. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. , 2005, The Journal of clinical investigation.
[21] M. Skobe,et al. Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. , 2005, Journal of the National Cancer Institute.
[22] Janet Rossant,et al. Dosage-sensitive requirement for mouse Dll4 in artery development. , 2004, Genes & development.
[23] J. Partanen,et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins , 2004, Nature Immunology.
[24] H. Augustin,et al. Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[25] Lena Claesson-Welsh,et al. Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites* , 2003, Journal of Biological Chemistry.
[26] K. Alitalo,et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia , 2003, The Journal of cell biology.
[27] N. Ferrara,et al. The biology of VEGF and its receptors , 2003, Nature Medicine.
[28] M. Shibuya,et al. VEGFR-2-specific ligand VEGF-E induces non-edematous hyper-vascularization in mice. , 2003, Biochemical and biophysical research communications.
[29] L. Miele,et al. The Notch Ligand Jagged-1 Is Able to Induce Maturation of Monocyte-Derived Human Dendritic Cells1 , 2002, The Journal of Immunology.
[30] T. Veikkola,et al. Lymphangiogenic Gene Therapy With Minimal Blood Vascular Side Effects , 2002, The Journal of experimental medicine.
[31] K. Alitalo,et al. Metastasis: Lymphangiogenesis and cancer metastasis , 2002, Nature Reviews Cancer.
[32] D. Kerjaschki,et al. Isolation and Characterization of Dermal Lymphatic and Blood Endothelial Cells Reveal Stable and Functionally Specialized Cell Lineages , 2001, The Journal of experimental medicine.
[33] M. Karkkainen,et al. The Specificity of Receptor Binding by Vascular Endothelial Growth Factor-D Is Different in Mouse and Man* , 2001, The Journal of Biological Chemistry.
[34] K. Alitalo,et al. Adenoviral Expression of Vascular Endothelial Growth Factor-C Induces Lymphangiogenesis in the Skin , 2001, Circulation research.
[35] M. Karkkainen,et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. , 2001, Cancer research.
[36] N. Ferrara,et al. Analysis of Biological Effects and Signaling Properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2) , 2001, The Journal of Biological Chemistry.
[37] Seppo Ylä-Herttuala,et al. Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3 , 2001, Nature Medicine.
[38] F. D. Miller,et al. Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain , 2000, Journal of neurochemistry.
[39] K. Alitalo,et al. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. , 2000, The American journal of pathology.
[40] T. Tsukamoto,et al. Establishment and characterization of a human lung cancer cell line NCI-H460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation. , 2000, Cancer research.
[41] D. Hicklin,et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. , 1999, Cancer research.
[42] K. Alitalo,et al. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. , 1999, American Journal of Pathology.
[43] G. Christofori,et al. Neural Cell Adhesion Molecule (N-CAM) Is Required for Cell Type Segregation and Normal Ultrastructure in Pancreatic Islets , 1999, The Journal of cell biology.
[44] K. Alitalo,et al. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. , 1998, Science.
[45] E. Tschachler,et al. Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3. , 1998, Cancer research.
[46] Lieve Moons,et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele , 1996, Nature.
[47] Kenneth J. Hillan,et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene , 1996, Nature.
[48] Janet Rossant,et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice , 1995, Nature.
[49] K. Alitalo,et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[50] H. Inoko,et al. Expression and function of class II antigens on gastric carcinoma cells and gastric epithelia: differential expression of DR, DQ, and DP antigens. , 1987, Journal of the National Cancer Institute.
[51] D. Hanahan,et al. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. , 1985, Nature.