Luminescent, mesoporous, and bioactive europium-doped calcium silicate (MCS: Eu3+) as a drug carrier.

Luminescent, mesoporous, and bioactive europium-doped calcium silicate (MCS: Eu) was successfully synthesized. The obtained MCS: Eu(3+) was performed as a drug delivery carrier to investigate the drug storage/release properties using ibuprofen (IBU) as the model drug. The structural, morphological, textural, and optical properties were well characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), N(2) adsorption/desorption, and photoluminescence (PL) spectra, respectively. The results reveal that the MCS: Eu exhibits the typical ordered characteristics of the mesostructure. This composite shows a sustained release profile with IBU as the model drug. The IBU-loaded samples still present red luminescence of Eu(3+) ((5)D(0)-(7)F(1,2)) under UV irradiation. The emission intensities of Eu(3+) in the drug carrier system vary with the amount of released IBU, making the drug release easily tracked and monitored. The system demonstrates a great potential for drug delivery and disease therapy.

[1]  Changsheng Liu,et al.  Development of calcium silicate/calcium phosphate cement for bone regeneration , 2007, Biomedical materials.

[2]  T. Higuchi.  MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES. , 1963, Journal of pharmaceutical sciences.

[3]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[4]  T Kitsugi,et al.  Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. , 1990, Journal of biomedical materials research.

[5]  Masahiro Yoshimura,et al.  Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants , 1998 .

[6]  J. Moradian-Oldak,et al.  Control of octacalcium phosphate and apatite crystal growth by amelogenin matrices , 2004 .

[7]  Larry L. Hench,et al.  Bioceramics: From Concept to Clinic , 1991 .

[8]  A. Scherz,et al.  Europium-labeled epidermal growth factor and neurotensin: novel probes for receptor-binding studies. , 2002, Analytical biochemistry.

[9]  G. F. Morgan.  Luminescent Materials , 1941, Nature.

[10]  Victor S-Y Lin,et al.  Stimuli-responsive controlled-release delivery system based on mesoporous silica nanorods capped with magnetic nanoparticles. , 2005, Angewandte Chemie.

[11]  D. Cowan,et al.  Boosting silica levels in wheat leaves reduces grazing by rabbits. , 2007, Pest management science.

[12]  T. Higuchi,et al.  Rate of release of medicaments from ointment bases containing drugs in suspension. , 1961, Journal of pharmaceutical sciences.

[13]  K. Okada,et al.  Effects of H2O in EtOH-H2O disperse medium on the electrophoretic deposition of CaSiO3 fine powder , 1999 .

[14]  F. Guitián,et al.  Bioeutectic: a new ceramic material for human bone replacement. , 1997, Biomaterials.

[15]  L. Francis,et al.  In vitro hydroxycarbonate apatite mineralization of CaO-SiO2 sol-gel glasses with a three-dimensionally ordered macroporous structure , 2001 .

[16]  Larry L. Hench,et al.  Bonding mechanisms at the interface of ceramic prosthetic materials , 1971 .

[17]  P. N. Aza,et al.  Reactivity of a wollastonite-tricalcium phosphate Bioeutectic ceramic in human parotid saliva. , 2000, Biomaterials.

[18]  Y. Kameshima,et al.  Formation of hydroxyapatite on CaSiO3 powders in simulated body fluid , 2002 .

[19]  Xuanyong Liu,et al.  Characterization of plasma sprayed wollastonite powder and coatings , 2002 .

[20]  Yufang Zhu,et al.  A template route to the preparation of mesoporous amorphous calcium silicate with high in vitro bone-forming bioactivity. , 2007, Journal of biomedical materials research. Part B, Applied biomaterials.

[21]  L. J. Bellamy.  The infra-red spectra of complex molecules , 1962 .

[22]  Yufang Zhu,et al.  Stimuli-responsive controlled drug release from a hollow mesoporous silica sphere/polyelectrolyte multilayer core-shell structure. , 2005, Angewandte Chemie.

[23]  Remo Guidieri.  Res , 1995, RES: Anthropology and Aesthetics.

[24]  Y. Urano,et al.  Development of a zinc ion-selective luminescent lanthanide chemosensor for biological applications. , 2004, Journal of the American Chemical Society.

[25]  Jiang Chang,et al.  Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. , 2008, Biomaterials.

[26]  Si-yu Ni,et al.  Study of the mechanical property and in vitro biocompatibility of CaSiO3 ceramics , 2005 .

[27]  Jenny Andersson,et al.  Influences of Material Characteristics on Ibuprofen Drug Loading and Release Profiles from Ordered Micro- and Mesoporous Silica Matrices , 2004 .

[28]  A. Hazar.  Preparation and in vitro bioactivity of CaSiO3 powders , 2007 .

[29]  F. Branda,et al.  Effect of the substitution of M2O3 (M = La, Y, In, Ga, Al) for CaO on the bioactivity of 2.5CaO x 2SiO2 glass. , 2002, Biomaterials.

[30]  Brian G. Trewyn,et al.  Mesoporous Silica Nanoparticles for Drug Delivery and Biosensing Applications , 2007 .

[31]  P. Taddei,et al.  Biomimetic calcium-silicate cements aged in simulated body solutions. Osteoblast response and analyses of apatite coating. , 2009, Journal of applied biomaterials & biomechanics : JABB.

[32]  X. Liu,et al.  Apatite formed on the surface of plasma-sprayed wollastonite coating immersed in simulated body fluid. , 2001, Biomaterials.

[33]  Jiang Chang,et al.  Preparation and the phase transformation behavior of amorphous mesoporous calcium silicate , 2008 .

[34]  M. Lindén,et al.  Sol-gel synthesis of a multifunctional, hierarchically porous silica/apatite composite. , 2005, Biomaterials.

[35]  Larry L Hench,et al.  Third-Generation Biomedical Materials , 2002, Science.

[36]  G. Tyler,et al.  Rare earth elements in soil and plant systems - A review , 2004, Plant and Soil.

[37]  T. Azaïs,et al.  Physical properties and in vitro bioactivity of hierarchical porous silica–HAP composites , 2007 .

[38]  F. Pooley,et al.  Biological reactivity of calcium silicate composites--in vitro studies. , 1981, Environmental research.

[39]  K. Burg,et al.  Biomaterial developments for bone tissue engineering. , 2000, Biomaterials.

[40]  Joseph L. Walter,et al.  The Infrared Spectra of Complex Molecules , 1982 .

[41]  M. Morra,et al.  Bioactive calcium silicate ceramics and coatings. , 2008, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[42]  María Vallet-Regí,et al.  Mesoporous materials for drug delivery. , 2007, Angewandte Chemie.

[43]  S. Cho,et al.  Induction of bioactivity of a non-bioactive glass-ceramic by a chemical treatment. , 1997, Biomaterials.

[44]  M. Vallet‐Regí,et al.  A New Property of MCM-41: Drug Delivery System , 2001 .

[45]  P. Cloirec,et al.  Characterization of Lanthanide Ions Binding Sites in the Cell Wall of Pseudomonas aeruginosa , 2000 .

[46]  M. Vallet‐Regí,et al.  In vitro calcium phosphate layer formation on sol-gel glasses of the CaO-SiO(2) system. , 1999, Journal of biomedical materials research.