A convenient four-component one-pot synthesis of 2-amino-1,3,4-thiadiazoles in water

[1]  Z. Ge,et al.  Propylene Oxide Assisted One-Pot, Tandem Synthesis of Substituted-1,3,4-oxadiazole-2(3H)-ones in Water. , 2013 .

[2]  S. Yang,et al.  Regioselective synthesis of 2-amino-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via reagent-based cyclization of thiosemicarbazide intermediate. , 2013, The Journal of organic chemistry.

[3]  Suresh Kumar,et al.  Design, Synthesis and Screening of Quinoline‐Incorporated Thiadiazole as a Potential Anticonvulsant , 2012, Chemical biology & drug design.

[4]  A. Shafiee,et al.  Synthesis and antileishmanial activity of novel 5-(5-nitrofuran-2-y1)-1,3,4-thiadiazoles with piperazinyl-linked benzamidine substituents. , 2011, European journal of medicinal chemistry.

[5]  K. Shah,et al.  One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles. , 2011, Bioorganic & medicinal chemistry letters.

[6]  V. Padmavathi,et al.  Synthesis and biological activity of 2-(bis((1,3,4-oxadiazolyl/1,3,4-thiadiazolyl)methylthio)methylene)malononitriles. , 2011, European journal of medicinal chemistry.

[7]  N. Siddiqui,et al.  Synthesis, anticonvulsant and toxicity screening of thiazolyl–thiadiazole derivatives , 2011, Medicinal Chemistry Research.

[8]  A. Shafiee,et al.  Synthesis and antileishmanial activity of 5-(5-nitroaryl)-2-substituted-thio-1,3,4-thiadiazoles , 2011, Journal of enzyme inhibition and medicinal chemistry.

[9]  Pinaki S. Bhadury,et al.  Synthesis and Antiviral Activity of 5‑(4‑Chlorophenyl)-1,3,4-Thiadiazole Sulfonamides , 2010, Molecules.

[10]  N. Al-Masoudi,et al.  Amino Acid Derivatives. Part 4. Synthesis and anti-HIV Activity of New Naphthalene Derivatives. , 2010 .

[11]  K. Shah,et al.  Synthesis and anticancer activity of 5-(3-indolyl)-1,3,4-thiadiazoles. , 2010, European journal of medicinal chemistry.

[12]  M. R. Saidi,et al.  Dithiocarbamate as an Efficient Intermediate for the Synthesis of 2-Amino-1,3,4-thiadiazoles in Water. , 2010 .

[13]  A. Amani,et al.  Efficient synthesis of 1,3,4‐thiadiazoles using hydrogen bond donor (thio)urea derivatives as organocatalysts , 2010 .

[14]  E. Korkusuz,et al.  Synthesis and reactions of 4-benzoyl-1,5-diaryl-1H-pyrazole-3-carbonyl chlorides with various semi- and thiosemicarbazides , 2010 .

[15]  M. R. Saidi,et al.  Dithiocarbamate as an efficient intermediate for the synthesis of 2-amino-1,3,4-thiadiazoles in water , 2010 .

[16]  A. Gürsoy,et al.  Synthesis, structure, and antifungal evaluation of some novel 1,2,4-triazolylmercaptoacetylthiosemicarbazide and 1,2,4-triazolylmercaptomethyl-1,3,4-thiadiazole analogs , 2010, Journal of enzyme inhibition and medicinal chemistry.

[17]  Z. Ge,et al.  An Efficient Four‐Component, One‐Pot Synthesis of Polysubstituted Pyrimidines in Water. , 2009 .

[18]  P. Mishra,et al.  Synthesis of Novel 2,5‐Disubstituted 1,3,4‐Thiadiazoles for Their Potential Anticonvulsant Activity: Pharmacophoric Model Studies , 2009, Archiv der Pharmazie.

[19]  Z. Ge,et al.  Synthesis of Highly SubstitutedPyridines via a One-Pot, Three-Component Cascade Reactionof Malononitrile with Aldehydes and S-AlkylisothiouroniumSalts in Water , 2009 .

[20]  Dennis G Hall,et al.  Natural product synthesis using multicomponent reaction strategies. , 2009, Chemical reviews.

[21]  A. Shafiee,et al.  Nitroimidazolyl-1,3,4-thiadiazole-based anti-leishmanial agents: synthesis and in vitro biological evaluation. , 2009, European journal of medicinal chemistry.

[22]  H. Kumar,et al.  1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: synthesis and preliminary evaluation of biological properties. , 2008, European journal of medicinal chemistry.

[23]  Ashok Kumar,et al.  Synthesis of new substituted azetidinoyl and thiazolidinoyl-1,3,4-thiadiazino (6,5-b) indoles as promising anti-inflammatory agents. , 2008, European journal of medicinal chemistry.

[24]  J. Matysiak,et al.  2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole analogues: Antifungal activity in vitro against Candida species , 2007, Russian Journal of Bioorganic Chemistry.

[25]  D. Tejedor,et al.  Chemo-Differentiating ABB′ Multicomponent Reactions: Privileged Building Blocks , 2007 .

[26]  Pinaki S. Bhadury,et al.  Synthesis and antifungal activities of 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-thiadiazole and 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-oxadiazole derivatives. , 2007, Bioorganic & medicinal chemistry.

[27]  A. Shafiee,et al.  A Mechanistic QSAR Study on the Leishmanicidal Activity of Some 5‐Substituted‐1,3,4‐Thiadiazole Derivatives , 2007, Chemical biology & drug design.

[28]  J. Matysiak,et al.  Synthesis and antiproliferative activity of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles. , 2006, Bioorganic & medicinal chemistry.

[29]  M. Świtalska,et al.  Synthesis and antiproliferative activity of some 5-substituted 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles. , 2006, European journal of medicinal chemistry.

[30]  D. Hall,et al.  Multicomponent Reactions in the Total Synthesis of Natural Products , 2005 .

[31]  J. Kilburn,et al.  Versatile strategies for the solid phase synthesis of small heterocyclic scaffolds: [1,3,4]-thiadiazoles and [1,3,4]-oxadiazoles , 2005 .

[32]  J. Chern,et al.  Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells. , 2003, Biochemical pharmacology.

[33]  G. Şener,et al.  Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities. , 2002, Bioorganic & medicinal chemistry.

[34]  Shuiming Lu,et al.  FACILE AND EFFICIENT SYNTHESIS OF α-AMINOPHOSPHONATE DERIVATIVES OF 1,3,4-OXADIAZOLE AND 1,3,4-THIADIAZOLE , 2000 .

[35]  Q. Xue,et al.  Study on 1,3,4-thiadiazole derivatives as novel multifunctional oil additives , 1999 .

[36]  R. D. Dyer,et al.  Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series. , 1999, Journal of medicinal chemistry.

[37]  S. Jung,et al.  Theoretical Study of the Nonlinear Optical Properties of Thiophene, Furan, Pyrrole, (1,2,4‐Triazole), (1,3,4‐Oxadiazole), and (1,3,4‐Thiadiazole) Monomers and Oligomers. , 1998 .

[38]  C. Supuran,et al.  Carbonic anhydrase inhibitors: ureido and thioureido derivatives of aromatic sulfonamides possessing increased affinities for isozyme I. A novel route to 2,5-disubstituted-1,3,4-thiadiazoles via thioureas, and their interaction with isozymes I, II and IV. , 1998, Journal of enzyme inhibition.

[39]  R. D. Dyer,et al.  1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities. , 1993, Journal of medicinal chemistry.

[40]  R. D. Dyer,et al.  Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents. , 1993, Journal of medicinal chemistry.

[41]  T. Hasegawa,et al.  Antitumor activity of 5-substituted 2-acylamino-1,3,4-thiadiazoles against transplantable rodent tumors. , 1985, Chemical & pharmaceutical bulletin.

[42]  S. Suman,et al.  Synthesis of 2‐Aryl Amino‐5‐Aryl/Aryloxy Methyl‐1,3,4‐Oxadiazoles, 2‐Aryl Amino‐5‐Aryl/Aryloxy Methyl‐1,3,4‐Thiadiazoles, N1‐Aryl/Aryloxy Acetyl‐3,5‐DimethylPyrazoles and N1‐Aryl/Aryloxy Acetyl‐3‐Methyl‐5‐Pyrazolones as Possible Fungicides. , 1979 .

[43]  F. Buccheri,et al.  Reactivity of the A-CH=N=NR-CX-B System. 1,3,4-thiadiazoles and Δ2 -thiadiazolines , 1977 .

[44]  R. Glennon,et al.  Mesoionic purinone analogs. 7. In vitro antibacterial activity of mesoionic 1,3,4-thiadiazolo(3,2-a)pyrimidine-5,7-diones. , 1974, Journal of medicinal chemistry.

[45]  A. Mauger,et al.  Some hypotensive thiadiazoles. , 1972, Journal of medicinal chemistry.

[46]  M. Mhasalkar,et al.  Synthesis and hypoglycemic activity of 3-aryl(or pyridyl)-5-alkyl(or aryl)amino-1,3,4-thiadiazoles and some sulfonylurea derivatives of 4H-1,2,4-triazoles. , 1971, Journal of medicinal chemistry.

[47]  C. W. Whitehead,et al.  Reactions of Orthoesters with Ureas. II , 1955 .

[48]  M. Faramarzi,et al.  Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. , 2011, European journal of medicinal chemistry.

[49]  D. Doğruer,et al.  Synthesis and antimicrobial activity of new 1,2,4-triazole and 1,3,4-thiadiazole derivatives. , 2008, Journal of enzyme inhibition and medicinal chemistry.

[50]  R. D. Dyer,et al.  Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series. , 1999, Journal of medicinal chemistry.

[51]  C. Supuran,et al.  Carbonic anhydrase inhibitors - Part 57 : Quantum chemical QSAR of a group of 1,3,4-thiadiazole- and 1,3,4-thiadiazoline disulfonamides with carbonic anhydrase inhibitory properties , 1999 .

[52]  R. D. Dyer,et al.  Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series. , 1999, Journal of medicinal chemistry.

[53]  Jinghan Gui.  The Synthesis and Biological Activity of 1-Aryl-4-substituted Pyrazoloyl Thiosemicarbazides and Related Heterocyclic Compounds , 1997 .

[54]  C. Supuran,et al.  1,3,4-THIADIAZOLE DERIVATIVES. PART 8 : BINUCLEAR COMPLEXES OF CU(II), MN(II), CO(II), NI(II) AND ZN(II) WITH A SCHIFF BASE DERIVED FROM 5-AMINO-1,3,4 -THIADIAZOLE-2-SULFONAMIDE , 1997 .

[55]  Z. Zhenghua,et al.  Color Photographic Development Accelerators: Part IV: Adsorption of hydrazines containing the 1,3,4-thiadiazole heterocyclic system on silver halides , 1993 .

[56]  S. Zareba.  Spektrophotometrische Fe(II)-Bestimmung in Arzneizubereitungen mittels Azofarbstoffen aus der 1,3,4-Thiadiazol- und 1,2,4-Triazol-Reihe , 1993 .

[57]  Z. Zhenghua,et al.  Color photographic development accelerators , 1991 .

[58]  C. Chapleo,et al.  Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 4. Amidines. , 1988, Journal of medicinal chemistry.