Biology of wound healing.

A clear understanding of wound healing is vital to a rational surgical approach. This article describes the major biologic processes of tissue repair and the factors influencing the healing processes, and it discusses specific wound-healing problems and recommends management regimens.

[1]  T. K. Hunt,et al.  Direct measurement of wound and tissue oxygen tension in postoperative patients. , 1983, Annals of surgery.

[2]  J. Neifeld,et al.  Lack of effect of Vitamin A on corticosteroid-induced immunosuppression. , 1975, The Journal of surgical research.

[3]  T. K. Hunt,et al.  Effects of Cortisone and Vitamin A on Wound Healing , 1968, Annals of surgery.

[4]  T. K. Hunt,et al.  The Effects of Cortisone and Anabolic Steroids on the Tensile Strength of Healing Wounds , 1969, Annals of surgery.

[5]  M. Dobke,et al.  Antinuclear (ANA), antimitochondrial (AMA) and anti-smooth muscles (SMA) autoantibodies following thermal trauma , 1978 .

[6]  T. K. Hunt,et al.  Deficient collagen formation by obese mice in a standard wound model. , 1979, American journal of surgery.

[7]  B. Hirschel,et al.  Contraction of Granulation Tissue in vitro: Similarity to Smooth Muscle , 1971, Science.

[8]  I. K. Cohen,et al.  The Role of Macrophages in Wound Repair: A Review , 1981, Plastic and reconstructive surgery.

[9]  T. K. Hunt,et al.  Wound healing and the diabetic patient. , 1979, Surgery, gynecology & obstetrics.

[10]  Peter J. E. Cruse,et al.  A five-year prospective study of 23,649 surgical wounds. , 1973, Archives of surgery.

[11]  T. K. Hunt,et al.  Effect of Vitamin A on Reversing the Inhibitory Effect of Cortisone on Healing of Open Wounds in Animals and Man , 1969, Annals of surgery.

[12]  Irvin Tt,et al.  Effects of malnutrition and hyperalimentation on wound healing. , 1978 .

[13]  E. Peacock,et al.  Biologic basis for the treatment of keloids and hypertrophic scars. , 1970 .

[14]  W. Goodson,et al.  Studies of wound healing in experimental diabetes mellitus. , 1977, The Journal of surgical research.

[15]  Herrmann Jb,et al.  Stimulation of fibroplasia by vitamin A. , 1969 .

[16]  J. Desprez,et al.  THE EFFECTS OF CYTOXAN (CYCLOPHOSPHAMIDE) ON WOUND HEALING , 1960, Plastic and reconstructive surgery and the transplantation bulletin.

[17]  C. F. Tessmer Radiation effects on the skin , 1991 .

[18]  I. K. Cohen,et al.  Immunoglobulin, Complement, and Histocompatibility Antigen Studies in Keloid Patients , 1979, Plastic and reconstructive surgery.

[19]  S. Benson,et al.  Inhibition of lysyl oxidase and prolyl hydroxylase activity in glucocorticoid treated rats. , 1981, Biochemical and biophysical research communications.

[20]  R. Ross,et al.  A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[21]  B. Baker,et al.  Interference with wound healing by the local action of adrenocortical steroids. , 1950, Endocrinology.

[22]  J. Niinikoski Oxygen and wound healing. , 1977 .

[23]  R. Rudolph,et al.  The Ultrastructure and Etiology of Chronic Radiotherapy Damage in Human Skin , 1982, Annals of plastic surgery.

[24]  I. K. Cohen,et al.  Effect of corticosteroids on collagen synthesis. , 1977, Surgery.

[25]  M Rojkind,et al.  The extracellular matrix of the liver. , 1982, Collagen and related research.

[26]  E. Seifter,et al.  Influence of vitamin A on wound healing in rats with femoral fracture. , 1975, Annals of surgery.

[27]  S. Wahl,et al.  The effect of complement depletion on wound healing. , 1974, The American journal of pathology.

[28]  N. Sandberg,et al.  Influence of acute hemorrhage on wound healing in the rabbit. , 1960, Acta chirurgica Scandinavica.

[29]  N. Sandberg TIME RELATIONSHIP BETWEEN ADMINISTRATION OF CORTISONE AND WOUND HEALING IN RATS. , 1964, Acta chirurgica Scandinavica.

[30]  M. Nimni Penicillamine and collagen metabolism. , 1979, Scandinavian journal of rheumatology. Supplement.

[31]  E. Peacock,et al.  Administration of beta-aminopropionitrile to human beings with urethral strictures: A prelimary report. , 1978, American journal of surgery.

[32]  R. D. Harkness,et al.  The effect of a protein‐free diet on the collagen content of mice , 1958, The Journal of physiology.

[33]  P. Peltokallio,et al.  The effect of high dose cyclophosphamide therapy in the abdominal cavity of the rat: adhesions and their vascular pattern. , 1974, Annales chirurgiae et gynaecologiae Fenniae.

[34]  R. Craig,et al.  Collagen Biosynthesis in Normal Human Skin, Normal and Hypertrophic Scar and Keloid , 1975, European journal of clinical investigation.

[35]  E. J. Weringer,et al.  Wound healing: a model for the study of diabetic angiopathy. , 1976, Diabetes.

[36]  A. Ooshima Collagen alpha B chain: increased proportion in human atherosclerosis. , 1981, Science.

[37]  I. K. Cohen,et al.  Collagen synthesis in human keloid and hypertrophic scar. , 1972, Surgical forum.

[38]  R. Ross,et al.  The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. , 1975, The American journal of pathology.

[39]  I. K. Cohen,et al.  Onset and Localization of Collagen Synthesis during Wound Healing in Open Rat Skin Wounds 1 , 1979, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[40]  E. Seifter,et al.  Impaired Wound Healing in Streptozotocin Diabetes: Prevention by Supplemental Vitamin A , 1981, Annals of surgery.

[41]  E. Widdowson,et al.  RESPONSE OF YOUNG RATS TO DEPRIVATION OF PROTEIN OR OF CALORIES. , 1963, The British journal of nutrition.

[42]  I. Tannock,et al.  Influence of vitamin A on immunological response. , 1972, Immunology.

[43]  S. Abston,et al.  Tissue levels of various globulins in burned patients. , 1971, The Journal of trauma.

[44]  I. K. Cohen,et al.  TISSUE ALPHA‐GLOBULINS IN KELOID FORMATION , 1977, Plastic and reconstructive surgery.

[45]  A. Kang,et al.  Collagen-and collagen peptide-induced chemotaxis of human blood monocytes , 1976, The Journal of experimental medicine.

[46]  E. Peacock,et al.  Induction of collagen synthesis in rats by transplantation of allogenic macrophages. , 1976, Surgical forum.

[47]  E. Seifter,et al.  Dysnutrition, wound healing, and resistance to infection. , 1977, Clinics in plastic surgery.

[48]  Madden Jw,et al.  Some studies on the effects of beta-aminopropionitrile in patients with injured flexor tendons. , 1969 .

[49]  Griffith Bh The treatment of keloids with triamcinolone acetonide. , 1966 .

[50]  J. Gross,et al.  Collagenolytic activity during mammalian wound repair. , 1967, Developmental biology.

[51]  S. Krane,et al.  Effects of colchicine on collagenase in cultures of rheumatoid synovium. , 1971, Arthritis and rheumatism.

[52]  S. Rittgers,et al.  Prediction of amputation wound healing. Roles of Doppler ultrasound and digit photoplethysmography. , 1981, Archives of surgery.

[53]  G. Brazenor,et al.  The effect of vitamin A on the immunosuppressive action of cortisone on skin homografts in mice. , 1973, The Australian and New Zealand journal of surgery.

[54]  R. Nakamura,et al.  Biochemical evaluation of postsurgical wound repair: prevention of intraperitoneal adhesion formation with ibuprofen. , 1983, The Journal of surgical research.

[55]  T. K. Hunt,et al.  Effect of Delayed Administration of Corticosteroids on Wound Contraction , 1971, Annals of surgery.

[56]  R. Rutherford,et al.  Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate , 1976, The Journal of cell biology.

[57]  T. R. Allen,et al.  Beneficial effects of immediate postoperative total parenteral nutrition. , 1971, Surgical forum.

[58]  I K Cohen,et al.  An update on wound healing. , 1979, Annals of plastic surgery.

[59]  R. Diegelmann,et al.  Inhibition of collagen secretion from bone and cultured fibroblasts by microtubular disruptive drugs. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[60]  C. Plotz,et al.  Retardation of wound healing by cortisone. , 1950, Surgery.

[61]  T. K. Hunt,et al.  The Effect of Differing Ambient Oxygen Tensions on Wound Infection , 1975, Annals of surgery.

[62]  S. Schultz-Haudt,et al.  Dynamics of the inflammatory reaction. , 1966, Journal of periodontal research.

[63]  R. Rudolph Complications of Surgery for Radiotherapy Skin Damage , 1982, Plastic and reconstructive surgery.

[64]  J. Uitto,et al.  Synthesis and secretion of under-hydroxylated procollagen at various temperatures by cells subject to temporary anoxia. , 1974, Biochemical and Biophysical Research Communications - BBRC.

[65]  T. K. Hunt,et al.  Effects of Vitamin A and Glucocorticoids upon Inflammation and Collagen Synthesis , 1973, Annals of surgery.

[66]  R. Ross,et al.  The neutrophilic leukocyte in wound repair a study with antineutrophil serum. , 1972, The Journal of clinical investigation.

[67]  F. Bozzetti,et al.  Parenteral hyperalimentation and wound healing. , 1975, Surgery, gynecology & obstetrics.

[68]  A. Eisen,et al.  Human skin collagenase. The role of serum alpha-globulins in the control of activity in vivo and in vitro. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[69]  S. Abston,et al.  Serum protein profiles in thermal burns. I. Serum electrophoretic patterns, immunoglobulins, and transport proteins. , 1974, The Journal of trauma.

[70]  I. K. Cohen,et al.  Vitamin A: adjuvant and steroid antagonist in the immune response. , 1973, Journal of immunology.

[71]  Madden Jw,et al.  Studies on the biology of collagen during wound healing. I. Rate of collagen synthesis and deposition in cutaneous wounds of the rat. , 1968, Surgery.

[72]  J. Milsom,et al.  Collagen degradation in cultured keloid and hypertrophic scar tissue , 1973, The British journal of dermatology.

[73]  V. Albergoni,et al.  Effect of penicillamine on some metals and metalloproteins in the rat. , 1975, Biochemical pharmacology.

[74]  D. Costello,et al.  Alteration of proline hydroxylase activity by glucocorticoids. , 1971, Biochemical pharmacology.

[75]  L. D. Ketchum,et al.  The Treatment of Hypertrophic Scar, Keloid and Scar Contracture by Triamcinolone Acetonide , 1966, Plastic and reconstructive surgery.

[76]  S. Abston,et al.  Serum protein profiles in thermal burns. II. Protease inhibitors, complement factors, and c-reactive protein. , 1974, The Journal of trauma.

[77]  R. Ross,et al.  A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro. , 1976, The American journal of pathology.

[78]  T. K. Hunt,et al.  Evidence for the involvement of microtubules in wound contraction. , 1977, American journal of surgery.