Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity.
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George C Schatz | Matthew D Disney | HaJeung Park | Jessica L. Childs-Disney | Jessica L Childs-Disney | Ilyas Yildirim | M. Disney | G. Schatz | Hajeung Park | Ilyas Yildirim | Jeremy R Lohman | Lirui Guan | Tuan Tran | Partha Sarkar | T. Tran | L. Guan | J. Lohman | P. Sarkar | Jessica L. Childs‐Disney
[1] M. Disney,et al. Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor. , 2014, Chemical Communications.
[2] Juan J. Marugan,et al. Induction and Reversal of Myotonic Dystrophy Type 1 Pre-mRNA Splicing Defects by Small Molecules , 2013, Nature Communications.
[3] J. Fransen,et al. Design and Analysis of Effects of Triplet Repeat Oligonucleotides in Cell Models for Myotonic Dystrophy , 2013, Molecular therapy. Nucleic acids.
[4] Two new drugs for homozygous familial hyperchelesterolemia. , 2013, The Medical letter on drugs and therapeutics.
[5] Jessica L. Childs-Disney,et al. Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1. , 2012, ACS chemical biology.
[6] J. Berglund,et al. Utilizing the GAAA tetraloop/receptor to facilitate crystal packing and determination of the structure of a CUG RNA helix. , 2012, Biochemistry.
[7] Bruce M. Wentworth,et al. Targeting nuclear RNA for in vivo correction of myotonic dystrophy , 2012, Nature.
[8] T. Cooper,et al. RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1 , 2012, Proceedings of the National Academy of Sciences.
[9] M. Disney,et al. Recent advances in developing small molecules targeting RNA. , 2012, ACS chemical biology.
[10] A. Baranger,et al. MBNL1–RNA Recognition: Contributions of MBNL1 Sequence and RNA Conformation , 2012, Chembiochem : a European journal of chemical biology.
[11] G. van Ommen,et al. Targeting Several CAG Expansion Diseases by a Single Antisense Oligonucleotide , 2011, PloS one.
[12] M. Disney,et al. Influencing uptake and localization of aminoglycoside-functionalized peptoids. , 2011, Molecular bioSystems.
[13] A. Baranger,et al. Selective inhibition of MBNL1–CCUG interaction by small molecules toward potential therapeutic agents for myotonic dystrophy type 2 (DM2)† , 2011, Nucleic acids research.
[14] A. Laquérriere,et al. Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy , 2011, Nature Medicine.
[15] D. Lilley,et al. Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking , 2011, Chemistry & biology.
[16] N. Greig,et al. The alpha-synuclein 5′untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen , 2011, Journal of Neural Transmission.
[17] Eric B. Roesch,et al. Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat. , 2010, Biochemistry.
[18] Harry A. Stern,et al. Reparameterization of RNA χ Torsion Parameters for the AMBER Force Field and Comparison to NMR Spectra for Cytidine and Uridine , 2010, Journal of chemical theory and computation.
[19] S. Richard,et al. Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients , 2010, The EMBO journal.
[20] Jessica L. Childs-Disney,et al. The Role of Flexibility in the Rational Design of Modularly Assembled Ligands Targeting the RNAs that Cause the Myotonic Dystrophies , 2010, Chembiochem : a European journal of chemical biology.
[21] Giulio Rastelli,et al. Fast and accurate predictions of binding free energies using MM‐PBSA and MM‐GBSA , 2009, J. Comput. Chem..
[22] G. Breningstall. Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy , 2010 .
[23] A. Baranger,et al. A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding , 2009, Proceedings of the National Academy of Sciences.
[24] B. Wieringa,et al. Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy , 2009, Proceedings of the National Academy of Sciences.
[25] J. H. Maddocks,et al. Conformational analysis of nucleic acids revisited: Curves+ , 2009, Nucleic acids research.
[26] Krzysztof Sobczak,et al. Reversal of RNA Dominance by Displacement of Protein Sequestered on Triplet Repeat RNA , 2009, Science.
[27] M. Disney,et al. Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2. , 2009, ACS chemical biology.
[28] D. Patel,et al. Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1 , 2008, Nature Structural &Molecular Biology.
[29] L. M. Alvarez-Salas,et al. Nucleic acids as therapeutic agents. , 2008, Current topics in medicinal chemistry.
[30] Matthew D Disney,et al. Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners. , 2008, Journal of the American Chemical Society.
[31] T. Cheatham,et al. Determination of Alkali and Halide Monovalent Ion Parameters for Use in Explicitly Solvated Biomolecular Simulations , 2008, The journal of physical chemistry. B.
[32] Paul J Hergenrother,et al. Targeting RNA with small molecules. , 2008, Chemical reviews.
[33] Warf Mb,et al. MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T , 2007 .
[34] Matthew D Disney,et al. A small molecule microarray platform to select RNA internal loop-ligand interactions. , 2007, ACS chemical biology.
[35] J. Holton,et al. Structural basis for aminoglycoside inhibition of bacterial ribosome recycling , 2007, Nature Structural &Molecular Biology.
[36] J. Šponer,et al. Refinement of the AMBER Force Field for Nucleic Acids: Improving the Description of α/γ Conformers , 2007 .
[37] Jessica L. Childs-Disney,et al. Using Selection to Identify and Chemical Microarray to Study the RNA Internal Loops Recognized by 6′‐N‐Acylated Kanamycin A , 2007, Chembiochem : a European journal of chemical biology.
[38] Yaser Hashem,et al. SwS: a solvation web service for nucleic acids , 2007, Bioinform..
[39] Daniel Svozil,et al. Refinement of the AMBER force field for nucleic acids: improving the description of alpha/gamma conformers. , 2007, Biophysical journal.
[40] S. Gullans,et al. Drug discovery targeted to the Alzheimer’s APP mRNA 5′-untranslated region , 2007, Journal of Molecular Neuroscience.
[41] Jeremy S Logue,et al. The structural basis of myotonic dystrophy from the crystal structure of CUG repeats. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[42] Rangarajan Sampath,et al. SAR by MS: discovery of a new class of RNA-binding small molecules for the hepatitis C virus: internal ribosome entry site IIA subdomain. , 2005, Journal of medicinal chemistry.
[43] Eric Westhof,et al. Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding , 2005, Nucleic acids research.
[44] Y. Cho‐Chung,et al. Killing the messenger: antisense DNA and siRNA. , 2004, Current drug targets.
[45] R. Andino,et al. Solution structure of a consensus stem-loop D RNA domain that plays important roles in regulating translation and replication in enteroviruses and rhinoviruses. , 2004, Biochemistry.
[46] Junmei Wang,et al. Development and testing of a general amber force field , 2004, J. Comput. Chem..
[47] Randy J Read,et al. Electronic Reprint Biological Crystallography Likelihood-enhanced Fast Rotation Functions Biological Crystallography Likelihood-enhanced Fast Rotation Functions , 2003 .
[48] J. Wöhnert,et al. The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C. , 2004, Structure.
[49] Randy J Read,et al. Electronic Reprint Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination , 2022 .
[50] E. Westhof,et al. X-ray crystal structures of antibiotic-RNA complexes , 2002 .
[51] R. Griffey,et al. SAR by MS: a ligand based technique for drug lead discovery against structured RNA targets. , 2002, Journal of medicinal chemistry.
[52] E. Garvey,et al. Small molecule modulators of HIV Rev/Rev response element interaction identified by random screening. , 2002, Antiviral research.
[53] P. Harper,et al. Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells. , 2002, Human molecular genetics.
[54] W. Delano. The PyMOL Molecular Graphics System , 2002 .
[55] Richard S Geary,et al. Fomivirsen: clinical pharmacology and potential drug interactions. , 2002, Clinical pharmacokinetics.
[56] M. Swanson,et al. Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2. , 2001, Human molecular genetics.
[57] Nathan A. Baker,et al. Electrostatics of nanosystems: Application to microtubules and the ribosome , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[58] G. Varani,et al. Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges. , 2001, Accounts of chemical research.
[59] S. Naylor,et al. Myotonic Dystrophy Type 2 Caused by a CCTG Expansion in Intron 1 of ZNF9 , 2001, Science.
[60] J. Sühnel,et al. Molecular Dynamics Simulation Reveals Conformational Switching of Water-Mediated Uracil-Cytosine Base Pairs in an RNA Duplex , 2022 .
[61] Steven,et al. SAR by MS , 2001 .
[62] V. Ramakrishnan,et al. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics , 2000, Nature.
[63] Y. Kyōgoku,et al. Solution structure of an RNA duplex including a C-U base pair. , 2000, Biochemistry.
[64] E. Westhof,et al. Aminoglycoside-RNA interactions. , 1999, Current opinion in chemical biology.
[65] D. Filman,et al. Crystal structure of a brominated RNA helix with four mismatched base pairs: An investigation into RNA conformational variability. , 1999, Biochemistry.
[66] J. Puglisi,et al. Recognition of the codon-anticodon helix by ribosomal RNA. , 1999, Science.
[67] A. Ferré-D’Amaré,et al. A general module for RNA crystallization. , 1998, Journal of molecular biology.
[68] E. Vivés,et al. Pharmacokinetics of oligonucleotides in cell culture. , 1997, Ciba Foundation symposium.
[69] O Kennard,et al. Structure of a mispaired RNA double helix at 1.6-A resolution and implications for the prediction of RNA secondary structure. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[70] I. Tinoco,et al. Crystal structure of an RNA double helix incorporating a track of non-Watson–Crick base pairs , 1991, Nature.
[71] Harry F. Noller,et al. Interaction of antibiotics with functional sites in 16S ribosomal RNA , 1987, Nature.
[72] W. L. Jorgensen,et al. Comparison of simple potential functions for simulating liquid water , 1983 .
[73] Hilla Peretz,et al. Ju n 20 03 Schrödinger ’ s Cat : The rules of engagement , 2003 .