Lung cancer screening.

A 60-year-old woman who quit smoking 20 years earlier comes for a routine visit. She previously smoked one pack of cigarettes a day for 10 years. Her medical history is otherwise unremarkable. Her husband smoked one pack of cigarettes per day for at least 30 years but stopped smoking a decade ago. She asks whether she and her husband should undergo computed tomographic scanning to screen for lung cancer. What do you advise?

[1]  U. Pastorino,et al.  Detection of microsatellite alterations in plasma DNA of non-small cell lung cancer patients: a prospect for early diagnosis. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[2]  G Z Brett,et al.  Earlier diagnosis and survival in lung cancer , 1969, British medical journal.

[3]  O. Miettinen,et al.  CT screening for lung cancer: suspiciousness of nodules according to size on baseline scans. , 2004, Radiology.

[4]  Martin Fiebich,et al.  Automatic detection of pulmonary nodules at spiral CT: clinical application of a computer-aided diagnosis system , 2002, European Radiology.

[5]  J. Concato,et al.  Randomized, controlled trials, observational studies, and the hierarchy of research designs. , 2000, The New England journal of medicine.

[6]  A. Kurt,et al.  Microsatellite alterations in plasma DNA of small cell lung cancer patients , 1996, Nature Medicine.

[7]  C. Heath,et al.  Smoking cessation and mortality trends among 118,000 Californians, 1960-1997. , 1999, Epidemiology.

[8]  W J Kostis,et al.  Computer-aided diagnosis for lung cancer. , 2000, Radiologic clinics of North America.

[9]  H. Ohmatsu,et al.  Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography. , 1996, Radiology.

[10]  C. Henschke,et al.  Managing the small pulmonary nodule discovered by CT. , 2004, Chest.

[11]  J Polák,et al.  Lung cancer detection results of a randomized prospective study in Czechoslovakia , 1986, Cancer.

[12]  Pierre P Massion,et al.  Novel strategies for the early detection and prevention of lung cancer. , 2005, Seminars in oncology.

[13]  D. Mark,et al.  Patient and hospital characteristics related to in-hospital mortality after lung cancer resection. , 1992, Chest.

[14]  Andrew Dalton,et al.  Cost-effectiveness analysis of screening for lung cancer with low dose spiral CT (computed tomography) in the Australian setting. , 2005, Lung cancer.

[15]  Hironobu Ohmatsu,et al.  Screening for lung cancer with low-dose helical computed tomography: anti-lung cancer association project. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[16]  C. Wells,et al.  Clinical features of lung cancers discovered as a postmortem "surprise". , 1986, Chest.

[17]  G. Bepler,et al.  Screening for lung cancer. , 2000, The New England journal of medicine.

[18]  CT screening for lung cancer: is smaller better? , 2002, American journal of respiratory and critical care medicine.

[19]  W F Taylor,et al.  Survival of patients surgically treated for stage I lung cancer. , 1981, The Journal of thoracic and cardiovascular surgery.

[20]  Daniel S. Miller,et al.  Annual report to the nation on the status of cancer, 1973-1996, with a special section on lung cancer and tobacco smoking. , 1999, Journal of the National Cancer Institute.

[21]  S. Swensen,et al.  Thoracic surgical operations in patients enrolled in a computed tomographic screening trial. , 2004, The Journal of thoracic and cardiovascular surgery.

[22]  M. Spitz,et al.  Lung carcinoma in former smokers , 1996, Cancer.

[23]  David J Brenner,et al.  Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancer. , 2004, Radiology.

[24]  W. Heindel,et al.  Low-dose CT: new tool for screening lung cancer? , 2001, European Radiology.

[25]  Peter B Bach,et al.  Lung cancer in US women: a contemporary epidemic. , 2004, JAMA.

[26]  F. Fazio,et al.  Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results , 2003, The Lancet.

[27]  J. Mulshine,et al.  Lung cancer screening: panacea or pipe dream? , 2005, Annals of oncology : official journal of the European Society for Medical Oncology.

[28]  C. Henschke Early lung cancer action project , 2000, Cancer.

[29]  N. Martini,et al.  The Surgical Treatment of Lung Cancer , 1982, Seminars in oncology.

[30]  M. Oda,et al.  [Results of surgical treatment of stage I lung cancer]. , 1993, Nihon Geka Gakkai zasshi.

[31]  B J Flehinger,et al.  Screening for early lung cancer. Results of the Memorial Sloan-Kettering study in New York. , 1984, Chest.

[32]  A. Hartz,et al.  A comparison of observational studies and randomized, controlled trials , 2000, American journal of ophthalmology.

[33]  O. Miettinen,et al.  Early Lung Cancer Action Project: overall design and findings from baseline screening , 1999, The Lancet.

[34]  S Capewell,et al.  Lung cancer in lifelong non-smokers. Edinburgh Lung Cancer Group. , 1991, Thorax.

[35]  E. Bergstralh,et al.  Screening for lung cancer. A critique of the mayo lung project , 1991, Cancer.

[36]  M. Tockman,et al.  Sensitive and specific monoclonal antibody recognition of human lung cancer antigen on preserved sputum cells: a new approach to early lung cancer detection. , 1988, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[37]  J. Mulshine,et al.  Radiologic screening for lung cancer , 2002, Expert review of anticancer therapy.

[38]  J. Herman,et al.  Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. , 1999, Cancer research.

[39]  P. Tassone,et al.  Detection of microsatellite instability and loss of heterozygosity in serum DNA of small and non-small cell lung cancer patients: a tool for early diagnosis? , 2000, Lung cancer.

[40]  E. Patz,et al.  Low-dose spiral computed tomography screening for lung cancer: not ready for prime time. , 2001, American journal of respiratory and critical care medicine.

[41]  S. Swensen,et al.  Lung cancer screening with CT: Mayo Clinic experience. , 2003, Radiology.

[42]  C. Mountain The new International Staging System for Lung Cancer. , 1986, The Surgical clinics of North America.

[43]  M. Stoeckli,et al.  Direct profiling of proteins in biological tissue sections by MALDI mass spectrometry. , 1999, Analytical chemistry.

[44]  W F Taylor,et al.  Lung cancer screening: the Mayo program. , 1986, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[45]  Feng Li,et al.  Mass screening for lung cancer with mobile spiral computed tomography scanner , 1998, The Lancet.

[46]  Melvyn S. Tockman,et al.  Survival and Mortality from Lung Cancer in a Screened Population: The Johns Hopkins Study , 1986 .

[47]  D. Page,et al.  Lung cancer classification: The relationship of disease extent and cell type to survival in a clinical trials population , 1987, Journal of surgical oncology.

[48]  John Eng,et al.  Lung cancer screening with helical computed tomography in older adult smokers: a decision and cost-effectiveness analysis. , 2003, JAMA.

[49]  Linda Humphrey,et al.  Lung Cancer Screening with Sputum Cytologic Examination, Chest Radiography, and Computed Tomography: An Update for the U.S. Preventive Services Task Force , 2004, Annals of Internal Medicine.

[50]  U. Pastorino,et al.  Quantification of Free Circulating DNA As a Diagnostic Marker in Lung Cancer , 2003 .

[51]  Anne-Marie Sykes,et al.  CT screening for lung cancer: five-year prospective experience. , 2005, Radiology.

[52]  U. Pastorino,et al.  Lung Cancers Detected by Screening with Spiral Computed Tomography Have a Malignant Phenotype when Analyzed by cDNA Microarray , 2004, Clinical Cancer Research.

[53]  Lung cancer overdiagnosis bias : "the gyanousa am loose!". , 2001, Chest.

[54]  C. Henschke,et al.  The cost-effectiveness of low-dose CT screening for lung cancer: preliminary results of baseline screening. , 2003, Chest.

[55]  David Spizarny,et al.  Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer. , 2005, Lung cancer.

[56]  P. Maloney,et al.  Cancer-specific genomic instability in bronchial lavage: a molecular tool for lung cancer detection. , 2001, Cancer research.

[57]  Wilson Jm,et al.  Principles and practice of mass screening for disease , 1968 .

[58]  A. Jemal,et al.  Cancer Statistics, 2005 , 2005, CA: a cancer journal for clinicians.

[59]  A. Mearns,et al.  Results of surgical treatment of stage I and II lung cancer. , 1996, The Journal of cardiovascular surgery.

[60]  S. Swensen,et al.  Screening for lung cancer with low-dose spiral computed tomography. , 2000, American journal of respiratory and critical care medicine.

[61]  James L Mulshine,et al.  Lung cancer screening. , 2005, The oncologist.

[62]  Marek Kimmel,et al.  CT screening for lung cancer: the first ten years. , 2002, Cancer journal.

[63]  L. Clarke,et al.  National Cancer Institute initiative: Lung image database resource for imaging research. , 2001, Academic radiology.