A controlled trial of methylprednisolone in the emergency treatment of acute asthma.

Ninety-seven acutely ill patients with bronchial asthma were enrolled in a double-blind, placebo-controlled, randomized trial of intravenous methylprednisolone (125 mg), given on presentation in the emergency room in addition to standard emergency treatments for asthma. Subjective and spirometric indexes of the severity of the asthma were similar on entry into the study in all patients, but only 9 of 48 patients (19 percent) treated with methylprednisolone required hospital admission, as compared with 23 of 49 patients (47 percent) in the control group (P less than 0.003). Our results suggest that prompt use of glucocorticoids in the emergency treatment of severe asthma can prevent significant morbidity, reduce the number of hospitalizations, and effect substantial savings in health care costs.

[1]  C. Berry,et al.  The immediate effects of cortisol on pulmonary function in normals and asthmatics. , 1983, The Journal of allergy and clinical immunology.

[2]  E. R. Mcfadden,et al.  Glucocorticoids in acute asthma. A critical controlled trial. , 1983, The American journal of medicine.

[3]  H. Chai,et al.  Corticosteroids in the treatment of acute exacerbations of asthma. , 1980, Annals of allergy.

[4]  J. Tukey.  Some thoughts on clinical trials, especially problems of multiplicity. , 1977, Science.

[5]  Klaustermeyer Wb,et al.  The physiologic effect of an intravenous glucocorticoid in bronchial asthma. , 1976 .

[6]  J. Morris.  Spirometry in the evaluation of pulmonary function. , 1976, The Western journal of medicine.

[7]  A. Rubinfeld,et al.  PERCEPTION OF ASTHMA , 1976, The Lancet.

[8]  E. R. Mcfadden,et al.  A controlled study of the effects of single doses of hydrocortisone on the resolution of acute attacks of asthma. , 1976, The American journal of medicine.

[9]  A. Fauci,et al.  Comparison of agents producing a neutrophilic leukocytosis in man. Hydrocortisone, prednisone, endotoxin, and etiocholanolone. , 1975, The Journal of clinical investigation.

[10]  F. Fenech,et al.  Intravenous prednisolone in chronic bronchial asthma. , 1975, Thorax.

[11]  W. Pierson,et al.  A double-blind trial of corticosteroid therapy in status asthmaticus. , 1974, Pediatrics.

[12]  A. Fauci,et al.  The effect of in vivo hydrocortisone on subpopulations of human lymphocytes. , 1974, The Journal of clinical investigation.

[13]  C. Parker,et al.  Alterations in cyclic AMP metabolism in human bronchial asthma. II. Leukocyte and lymphocyte responses to prostaglandins. , 1973, The Journal of clinical investigation.

[14]  S. Kalsner,et al.  Mechanism of Hydrocortisone Potentiation of Responses to Epinephrine and Norepinephrine in Rabbit Aorta , 1969, Circulation research.