The Size of Blood–Brain Barrier Opening Induced by Focused Ultrasound is Dictated by the Acoustic Pressure

[1]  Ankur Tyagi Focal delivery of AAV2/1-transgenes into the rat brain by localized ultrasound-induced BBB Opening , 2014, Annals of Neurosciences.

[2]  Kullervo Hynynen,et al.  Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound , 2013, Experimental Neurology.

[3]  Paul S. Sheeran,et al.  Targeted drug delivery with focus ultrasound-induced blood-brain barrier opening Using acoustically-activated nanodroplets , 2013, 2013 IEEE International Ultrasonics Symposium (IUS).

[4]  K. Hynynen,et al.  Noninvasive and targeted drug delivery to the brain using focused ultrasound. , 2013, ACS chemical neuroscience.

[5]  T. Yen,et al.  Noninvasive and Targeted Gene Delivery into the Brain Using Microbubble-Facilitated Focused Ultrasound , 2013, PloS one.

[6]  M. Hennerici,et al.  Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening , 2013, Molecular therapy. Nucleic acids.

[7]  Natalia Vykhodtseva,et al.  Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. , 2012, Ultrasound in medicine & biology.

[8]  D. Bihan,et al.  Dynamic study of blood-brain barrier closure after its disruption using ultrasound: a quantitative analysis. , 2012 .

[9]  Natalia Vykhodtseva,et al.  Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques. , 2012, Cancer research.

[10]  James J. Choi,et al.  Ultrasound-induced blood-brain barrier opening. , 2012, Current pharmaceutical biotechnology.

[11]  James J. Choi,et al.  Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood–brain barrier using focused ultrasound and microbubbles , 2012, Physics in medicine and biology.

[12]  Kullervo Hynynen,et al.  Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller. , 2012, Radiology.

[13]  Zhibiao Wang,et al.  Targeted gene delivery to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption , 2012, Experimental Neurology.

[14]  Yao-Sheng Tung,et al.  The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in mice. , 2011, The Journal of the Acoustical Society of America.

[15]  V. Ferrera,et al.  Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates. , 2011, Applied physics letters.

[16]  Wayne Kreider,et al.  Blood vessel deformations on microsecond time scales by ultrasonic cavitation. , 2011, Physical review letters.

[17]  Cheri X Deng,et al.  Targeted drug delivery across the blood-brain barrier using ultrasound technique. , 2010, Therapeutic delivery.

[18]  K. Hynynen,et al.  Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats , 2010, BMC neurology.

[19]  Yao-Sheng Tung,et al.  In vivo transcranial cavitation threshold detection during ultrasound-induced blood–brain barrier opening in mice , 2010, Physics in medicine and biology.

[20]  James J. Choi,et al.  In vivo transcranial cavitation detection during ultrasound-induced blood-brain barrier opening , 2010, 2010 IEEE International Ultrasonics Symposium.

[21]  Yao-Sheng Tung,et al.  Multi-modality safety assessment of blood-brain barrier opening using focused ultrasound and definity microbubbles: a short-term study. , 2010, Ultrasound in medicine & biology.

[22]  Rajiv Chopra,et al.  Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease , 2010, PloS one.

[23]  M. Hennerici,et al.  Reorganization of Gap Junctions after Focused Ultrasound Blood–Brain Barrier Opening in the Rat Brain , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[24]  R. Gabathuler,et al.  Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases , 2010, Neurobiology of Disease.

[25]  Kullervo Hynynen,et al.  Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium. , 2008, Ultrasound in medicine & biology.

[26]  K. Hynynen,et al.  Ultrasound Enhanced Delivery of Molecular Imaging and Therapeutic Agents in Alzheimer's Disease Mouse Models , 2008, PloS one.

[27]  Manabu Kinoshita,et al.  Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[28]  Nico de Jong,et al.  Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[29]  K. Hynynen,et al.  Targeted disruption of the blood–brain barrier with focused ultrasound: association with cavitation activity , 2006, Physics in medicine and biology.

[30]  Natalia Vykhodtseva,et al.  MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits. , 2005, Ultrasound in medicine & biology.

[31]  K. Hynynen,et al.  Targeted disruption of the blood-brain barrier with focused ultrasound: association with inertial cavitation , 2005, IEEE Ultrasonics Symposium, 2005..

[32]  K. Hynynen,et al.  Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. , 2004, Ultrasound in medicine & biology.

[33]  Akira Tsuji,et al.  Drug delivery through the blood-brain barrier , 1996 .

[34]  L. Lebrun,et al.  Diffusion of dextran through microporous membrane filters , 1994 .

[35]  M. Danhof,et al.  Drug transport across the blood-brain barrier , 1992, Pharmaceutisch Weekblad.

[36]  S. Rapoport,et al.  Size selectivity of blood-brain barrier permeability at various times after osmotic opening. , 1987, The American journal of physiology.

[37]  D. Heistad,et al.  Permeability of blood-brain barrier to various sized molecules. , 1985, The American journal of physiology.

[38]  Yao-Sheng Tung,et al.  Microbubble-Size Dependence of Focused Ultrasound-Induced Blood–Brain Barrier Opening in Mice In Vivo , 2010, IEEE Transactions on Biomedical Engineering.

[39]  Yao-Sheng Tung,et al.  Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo. , 2010, Ultrasound in medicine & biology.

[40]  James J. Choi,et al.  Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice. , 2007, Ultrasound in medicine & biology.