IL-6 and Maturation Govern TLR2 and TLR4 Induced TLR Agonist Tolerance and Cross-Tolerance in Dendritic Cells

[1]  Y. Yanagawa,et al.  Enhanced IL-10 Production by TLR4- and TLR2-Primed Dendritic Cells upon TLR Restimulation1 , 2007, The Journal of Immunology.

[2]  N. Perkins,et al.  Integrating cell-signalling pathways with NF-κB and IKK function , 2007, Nature Reviews Molecular Cell Biology.

[3]  C. McCall,et al.  Induction of RelB Participates in Endotoxin Tolerance1 , 2006, The Journal of Immunology.

[4]  S. Akira,et al.  Toll-like receptors and innate immunity , 2006, Journal of Molecular Medicine.

[5]  I. Autenrieth,et al.  Colitogenic and non‐colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: An important role for IL‐6 , 2006, European journal of immunology.

[6]  H. Lochs,et al.  Spatial Organization and Composition of the Mucosal Flora in Patients with Inflammatory Bowel Disease , 2005, Journal of Clinical Microbiology.

[7]  U. Grohmann,et al.  Cutting Edge: Silencing Suppressor of Cytokine Signaling 3 Expression in Dendritic Cells Turns CD28-Ig from Immune Adjuvant to Suppressant1 , 2005, The Journal of Immunology.

[8]  F. Re,et al.  IL-10 Released by Concomitant TLR2 Stimulation Blocks the Induction of a Subset of Th1 Cytokines That Are Specifically Induced by TLR4 or TLR3 in Human Dendritic Cells1 , 2004, The Journal of Immunology.

[9]  F. Schmitz,et al.  Transcriptional activation induced in macrophages by Toll‐like receptor (TLR) ligands: from expression profiling to a model of TLR signaling , 2004, European journal of immunology.

[10]  T. Hirano,et al.  IL-6 Regulates In Vivo Dendritic Cell Differentiation through STAT3 Activation1 , 2004, The Journal of Immunology.

[11]  S. Hegde,et al.  Novel immunosuppressive properties of interleukin‐6 in dendritic cells: inhibition of NF‐κB binding activity and CCR7 expression , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  L. Ziegler‐Heitbrock,et al.  Tolerance Induced by the Lipopeptide Pam3Cys Is Due to Ablation of IL-1R-Associated Kinase-11 , 2004, The Journal of Immunology.

[13]  Shizuo Akira,et al.  Toll-like receptor signalling , 2004, Nature Reviews Immunology.

[14]  F. Liew,et al.  ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance , 2004, Nature Immunology.

[15]  S. Akira,et al.  IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages , 2003, Nature Immunology.

[16]  Ruslan Medzhitov,et al.  Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells , 2003, Science.

[17]  M. J. Cody,et al.  Induction of In Vitro Reprogramming by Toll-Like Receptor (TLR)2 and TLR4 Agonists in Murine Macrophages: Effects of TLR “Homotolerance” Versus “Heterotolerance” on NF-κB Signaling Pathway Components1 , 2003, The Journal of Immunology.

[18]  M. Rincón,et al.  The two faces of IL-6 on Th1/Th2 differentiation. , 2002, Molecular immunology.

[19]  Kenji Nakanishi,et al.  SOCS-1 participates in negative regulation of LPS responses. , 2002, Immunity.

[20]  M. Kubo,et al.  SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. , 2002, Immunity.

[21]  T. Crabtree,et al.  Preexposure of murine macrophages to CpG-containing oligonucleotides results in nuclear factor kappaB p50 homodimer-associated hyporesponsiveness. , 2002, Surgery.

[22]  S. Akira,et al.  Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins1 , 2002, The Journal of Immunology.

[23]  Thomas Hartung,et al.  Lipopolysaccharide- and Lipoteichoic Acid-Induced Tolerance and Cross-Tolerance: Distinct Alterations in IL-1 Receptor-Associated Kinase1 , 2002, The Journal of Immunology.

[24]  S. Kamiya,et al.  Experimental infection of germ-free mice with hyper-toxigenic enterohaemorrhagic Escherichia coli O157:H7, strain 6. , 2002, Journal of medical microbiology.

[25]  F. Re,et al.  Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells* , 2001, The Journal of Biological Chemistry.

[26]  J. Banchereau,et al.  Sensing Pathogens and Tuning Immune Responses , 2001, Science.

[27]  F. Sallusto,et al.  The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics. , 2001, Current opinion in immunology.

[28]  L. Ziegler-Heitbrock.  The p50-homodimer mechanism in tolerance to LPS , 2001, Journal of endotoxin research.

[29]  T. Hartung,et al.  Induction of Cross-Tolerance by Lipopolysaccharide and Highly Purified Lipoteichoic Acid Via Different Toll-Like Receptors Independent of Paracrine Mediators1 , 2001, The Journal of Immunology.

[30]  A. Aderem,et al.  Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism , 2001, Nature Immunology.

[31]  M. J. Cody,et al.  Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages , 2001, Infection and Immunity.

[32]  E. Kiss-Toth,et al.  Evidence for an Accessory Protein Function for Toll-Like Receptor 1 in Anti-Bacterial Responses1 , 2000, The Journal of Immunology.

[33]  S. Akira,et al.  Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways1 , 2000, The Journal of Immunology.

[34]  E. Fikrig,et al.  Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. , 2000, Immunity.

[35]  J. Banchereau,et al.  IL-6 switches the differentiation of monocytes from dendritic cells to macrophages , 2000, Nature Immunology.

[36]  Takatoshi Ito,et al.  Lipopolysaccharide‐triggered desensitization of TNF‐α mRNA expression involves lack of phosphorylation of IκBα in a murine macrophage‐like cell line, P388D1 , 2000, Journal of Leukocyte Biology.

[37]  M. Birrer,et al.  TNF-α Gene Expression in Macrophages: Regulation by NF-κB Is Independent of c-Jun or C/EBPβ1 , 2000, The Journal of Immunology.

[38]  S. Akira,et al.  Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression1 , 2000, The Journal of Immunology.

[39]  W. Ouyang,et al.  Signaling and transcription in T helper development. , 2000, Annual review of immunology.

[40]  D. Low,et al.  Assessment of bacterial pathogenesis by analysis of gene expression in the host. , 2000, Annual review of genetics.

[41]  David M. Rothwarf,et al.  The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus , 1999, Science's STKE.

[42]  G. Schuler,et al.  An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. , 1999, Journal of immunological methods.

[43]  P. Ricciardi-Castagnoli,et al.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. , 1998, Science.

[44]  Jean-François,et al.  Hyporesponsiveness to lipopolysaccharide alters the composition of NF‐κB binding to the regulatory regions of inducible nitric oxide synthase gene , 1998 .

[45]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[46]  T. Hirano.  Interleukin 6 and its receptor: ten years later. , 1998, International reviews of immunology.

[47]  R. Zinkernagel,et al.  Impaired immune and acute-phase responses in interleukin-6-deficient mice , 1994, Nature.

[48]  S. N. Vogel,et al.  An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance , 1991, Infection and immunity.