Predicting pulmonary adenocarcinoma outcome based on a cytology grading system

Pulmonary adenocarcinoma (AD) has a variety of architectural patterns. Recently, a 3‐tiered histological pattern‐based grading system was developed for stage I lung AD, stratifying patients into low, intermediate, and high risk for recurrence. However, cytology may serve as the primary method for diagnosis in patients with inoperable disease. Attempts to correlate architecture between parallel cytological and histological preparations have not been successful. Therefore, we evaluated cytomorphologic features of previously histologically graded AD to identify features of potential prognostic significance.

[1]  W. Travis,et al.  Suitability of Thoracic Cytology for New Therapeutic Paradigms in Non-small Cell Lung Carcinoma: High Accuracy of Tumor Subtyping and Feasibility of EGFR and KRAS Molecular Testing , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[2]  Masahiro Tsuboi,et al.  International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[3]  P Giraud,et al.  Chapter 44 – Non–Small Cell Lung Cancer , 2016 .

[4]  Akihiko Yoshizawa,et al.  A Grading System of Lung Adenocarcinomas Based on Histologic Pattern is Predictive of Disease Recurrence in Stage I Tumors , 2010, The American journal of surgical pathology.

[5]  L. Chirieac,et al.  Prognostic significance of grading in lung adenocarcinoma , 2010, Cancer.

[6]  Karsten Schlüns,et al.  Core classification of lung cancer: correlating nuclear size and mitoses with ploidy and clinicopathological parameters. , 2009, Lung cancer.

[7]  A. Moreira,et al.  Cytologic diagnosis of pulmonary adenocarcinoma with micropapillary pattern: Does it correlate with the histologic findings? , 2009, Diagnostic cytopathology.

[8]  H. Horinouchi,et al.  Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma , 2008, Modern Pathology.

[9]  W. Gerald,et al.  Lung Adenocarcinoma: Modification of the 2004 WHO Mixed Subtype to Include the Major Histologic Subtype Suggests Correlations Between Papillary and Micropapillary Adenocarcinoma Subtypes, EGFR Mutations and Gene Expression Analysis , 2008, The American journal of surgical pathology.

[10]  C. Henschke,et al.  Reliability of cytologic diagnosis of early lung cancer , 2007, Cancer.

[11]  C. Foucault,et al.  Prognostic value of histology in resected lung cancer with emphasis on the relevance of the adenocarcinoma subtyping. , 2006, The Annals of thoracic surgery.

[12]  H. Iwasaki,et al.  Micropapillary pattern: a distinct pathological marker to subclassify tumours with a significantly poor prognosis within small peripheral lung adenocarcinoma (≤20 mm) with mixed bronchioloalveolar and invasive subtypes (Noguchi's type C tumours) , 2005, Histopathology.

[13]  N. P. Ohori,et al.  Cytopathologic Diagnosis of Bronchioloalveolar Carcinoma , 2004 .

[14]  N. P. Ohori,et al.  Cytopathologic diagnosis of bronchioloalveolar carcinoma: does it correlate with the 1999 World Health Organization definition? , 2004, American journal of clinical pathology.

[15]  F. Erdoğan,et al.  Prognostic significance of morphologic parameters in renal cell carcinoma , 2004, International journal of clinical practice.

[16]  Jungsil Ro,et al.  Micropapillary Component in Lung Adenocarcinoma: A Distinctive Histologic Feature With Possible Prognostic Significance , 2002, The American journal of surgical pathology.

[17]  H. Yazdi,et al.  Fine‐needle aspiration biopsy of bronchioloalveolar carcinoma , 2001, Cancer.

[18]  D. Dabbs.  Prognostic information from fine-needle aspiration biopsy of breast carcinoma. , 2000, American journal of clinical pathology.

[19]  J. Silverman,et al.  Prognostic factors from the fine‐needle aspirate: Breast carcinoma nuclear grade , 1994, Diagnostic cytopathology.

[20]  E. Berg,et al.  World Health Organization Classification of Tumours , 2002 .

[21]  H. Hansen,et al.  Lung cancer. , 1990, Cancer chemotherapy and biological response modifiers.