A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities
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Roland Arnold | Laurence Pelletier | Andrew Emili | Hiromasa Tanaka | Charles Boone | Mohan Babu | Anastasia Baryshnikova | Philip M. Kim | Kevin R Brown | Philip M Kim | Troy Ketela | Anthony B Mak | Alessandro Datti | Robert Rottapel | Jason Moffat | Glauber C. Brito | Azin Sayad | A. Emili | J. Moffat | B. Andrews | Charles Boone | M. Babu | A. Baryshnikova | Yaroslav Fedyshyn | Taras Makhnevych | F. Vizeacoumar | T. Ketela | L. Pelletier | S. Lawo | Azin Sayad | Roland Arnold | Z. Wainberg | A. Datti | Jordan T. F. Young | F. Vizeacoumar | R. Rottapel | J. Wrana | Dahlia Kasimer | Anthony B. Mak | M. Chandrashekhar | P. Mero | Yadong Wang | Julian H. Kwan | Megha Chandrashekhar | Patricia Mero | Steffen Lawo | Taras Makhnevych | Franco J Vizeacoumar | Brenda Andrews | Zev Wainberg | A. Buzina | Jeff Wrana | Yaroslav Fedyshyn | Glauber C Brito | Frederick S Vizeacoumar | Dahlia Kasimer | Alla Buzina | Jordan T F Young | Julian H M Kwan | Yadong Wang | Catherine A O'Brien | K. Brown | C. O’Brien | Hiromasa Tanaka
[1] K. Kinzler,et al. Hyper-recombination and genetic instability in BLM-deficient epithelial cells. , 2003, Cancer research.
[2] K. Miyagawa,et al. Haploinsufficiency of the Mus81–Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells , 2006, Nucleic acids research.
[3] R. Wollman,et al. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. , 2009, Molecular cell.
[4] S. Shirasawa,et al. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. , 1993, Science.
[5] Alan Ashworth,et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy , 2005, Nature.
[6] Adam A. Margolin,et al. The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity , 2012, Nature.
[7] P. Jaccard,et al. Etude comparative de la distribution florale dans une portion des Alpes et des Jura , 1901 .
[8] Kara Dolinski,et al. The Princeton Protein Orthology Database (P-POD): A Comparative Genomics Analysis Tool for Biologists , 2007, PloS one.
[9] W. Kaelin,et al. Use and Abuse of RNAi to Study Mammalian Gene Function , 2012, Science.
[10] Damian Szklarczyk,et al. eggNOG v2.0: extending the evolutionary genealogy of genes with enhanced non-supervised orthologous groups, species and functional annotations , 2009, Nucleic Acids Res..
[11] David M. Sabatini,et al. Building mammalian signalling pathways with RNAi screens , 2006, Nature Reviews Molecular Cell Biology.
[12] Gary D Bader,et al. International network of cancer genome projects , 2010, Nature.
[13] Steven P Gygi,et al. A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. , 2007, Molecular cell.
[14] J. Ptak,et al. Three classes of genes mutated in colorectal cancers with chromosomal instability. , 2004, Cancer research.
[15] Gary D Bader,et al. Quantitative analysis of fitness and genetic interactions in yeast on a genome scale , 2010, Nature Methods.
[16] K. Kinzler,et al. Use of isogenic human cancer cells for high-throughput screening and drug discovery , 2001, Nature Biotechnology.
[17] Robert P. St.Onge,et al. The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes , 2008, Science.
[18] D. Durocher,et al. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes , 2008, Proceedings of the National Academy of Sciences.
[19] Stephen J. Elledge,et al. Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening , 2008, Science.
[20] Ben Lehner,et al. Evolutionary plasticity of genetic interaction networks , 2008, Nature Genetics.
[21] Michael T. McManus,et al. A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility , 2013, Cell.
[22] P. Deloukas,et al. Signatures of mutation and selection in the cancer genome , 2010, Nature.
[23] Kevin R Brown,et al. Essential gene profiles in breast, pancreatic, and ovarian cancer cells. , 2012, Cancer discovery.
[24] Anne-Claude Gingras,et al. A Lentiviral Functional Proteomics Approach Identifies Chromatin Remodeling Complexes Important for the Induction of Pluripotency* , 2010, Molecular & Cellular Proteomics.
[25] Joshua M. Stuart,et al. A global analysis of genetic interactions in Caenorhabditis elegans , 2007, Journal of biology.
[26] Mathias Allemand,et al. Mechanisms and Implications , 2013 .
[27] Jill P. Mesirov,et al. Cancer Vulnerabilities Unveiled by Genomic Loss , 2012, Cell.
[28] Yang Wang,et al. RRM1 gene expression in peripheral blood is predictive of shorter survival in Chinese patients with advanced non-small-cell lung cancer treated by gemcitabine and platinum , 2011, Journal of Zhejiang University SCIENCE B.
[29] Kohzoh Imai,et al. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. , 2005, Gastroenterology.
[30] James E. DiCarlo,et al. RNA-Guided Human Genome Engineering via Cas9 , 2013, Science.
[31] M. Kenward,et al. An Introduction to the Bootstrap , 2007 .
[32] P. Yaswen,et al. A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells , 2009, PloS one.
[33] C. Paweletz,et al. A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors , 2010, BMC Medical Genomics.
[34] Thomas Helleday,et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase , 2005, Nature.
[35] K. Matsumoto,et al. IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein. , 1990, Molecular and cellular biology.
[36] P. Pandolfi,et al. PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop. , 2008, Molecular cell.
[37] Ian M. Donaldson,et al. iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence , 2010, Database J. Biol. Databases Curation.
[38] Frederick S. Vizeacoumar,et al. Systematic exploration of essential yeast gene function with temperature-sensitive mutants , 2011, Nature Biotechnology.
[39] Erik L. L. Sonnhammer,et al. InParanoid 7: new algorithms and tools for eukaryotic orthology analysis , 2009, Nucleic Acids Res..
[40] R. Schimke. Methotrexate resistance and gene amplification. Mechanisms and implications , 1986, Cancer.
[41] Michael L. Creech,et al. Integration of biological networks and gene expression data using Cytoscape , 2007, Nature Protocols.
[42] Ji Luo,et al. Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction , 2009, Cell.
[43] S. Serrano,et al. Methotrexate resistance in vitro is achieved by a dynamic selectionprocess of tumor cell variants emerging during treatment , 2006, International journal of cancer.
[44] J. Moffat,et al. Pooled lentiviral shRNA screening for functional genomics in mammalian cells. , 2011, Methods in molecular biology.
[45] A. Ashworth,et al. Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1. , 2012, Cancer discovery.
[46] C. Greenman. Estimation of Rearrangement Phylogeny in Cancer , 2012 .
[47] Gary D Bader,et al. The Genetic Landscape of a Cell , 2010, Science.
[48] R. Durbin,et al. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes , 2010, Nature.
[49] K. Matsumoto,et al. IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae , 1989, Molecular and cellular biology.
[50] Thomas Lengauer,et al. ROCR: visualizing classifier performance in R , 2005, Bioinform..
[51] A. Børresen-Dale,et al. COMPLEX LANDSCAPES OF SOMATIC REARRANGEMENT IN HUMAN BREAST CANCER GENOMES , 2009, Nature.
[52] Le Cong,et al. Multiplex Genome Engineering Using CRISPR/Cas Systems , 2013, Science.
[53] Kim Nasmyth,et al. An ESP1/PDS1 Complex Regulates Loss of Sister Chromatid Cohesion at the Metaphase to Anaphase Transition in Yeast , 1998, Cell.
[54] P. Hieter,et al. Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing , 2009, Proceedings of the National Academy of Sciences.
[55] M. Gerstein,et al. Genomic analysis of regulatory network dynamics reveals large topological changes , 2004, Nature.
[56] Feng Chen,et al. OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups , 2005, Nucleic Acids Res..
[57] Stefan Götz,et al. SIMAP—a comprehensive database of pre-calculated protein sequence similarities, domains, annotations and clusters , 2009, Nucleic Acids Res..
[58] Jill P. Mesirov,et al. β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis , 2012, Cell.
[59] H. Himmelbauer,et al. An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division , 2004, Nature.
[60] T. Ideker,et al. Differential network biology , 2012, Molecular systems biology.
[61] A comprehensive platform for highly multiplexed mammalian functional genetic screens , 2011, BMC Genomics.
[62] B. Fleischer,et al. CD83 regulates lymphocyte maturation, activation and homeostasis. , 2008, Trends in immunology.
[63] Erik L. L. Sonnhammer,et al. Inparanoid: a comprehensive database of eukaryotic orthologs , 2004, Nucleic Acids Res..
[64] Ben S. Wittner,et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 , 2009, Nature.
[65] J. Mesirov,et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer , 2011, Proceedings of the National Academy of Sciences.
[66] M. Mann,et al. A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly , 2011, Nature Cell Biology.
[67] Alan Mackay,et al. Functional viability profiles of breast cancer. , 2011, Cancer discovery.
[68] L. Hesson,et al. RASSF2 associates with and stabilizes the proapoptotic kinase MST2 , 2009, Oncogene.
[69] N. Hacohen,et al. Highly parallel identification of essential genes in cancer cells , 2008, Proceedings of the National Academy of Sciences.
[70] Nir Hacohen,et al. Genome-scale loss-of-function screening with a lentiviral RNAi library , 2006, Nature Methods.
[71] R. Durbin,et al. Systematic Analysis of Human Protein Complexes Identifies Chromosome Segregation Proteins , 2010, Science.
[72] Kara Dolinski,et al. The BioGRID Interaction Database: 2011 update , 2010, Nucleic Acids Res..
[73] H. Dai,et al. Biomarker Discovery: Identification of a Growth Factor Gene Signature , 2009, Clinical pharmacology and therapeutics.
[74] Tsviya Olender,et al. GeneCards Version 3: the human gene integrator , 2010, Database J. Biol. Databases Curation.
[75] A. Hyman,et al. HAUS, the 8-Subunit Human Augmin Complex, Regulates Centrosome and Spindle Integrity , 2009, Current Biology.
[76] L. Hartwell,et al. Integrating genetic approaches into the discovery of anticancer drugs. , 1997, Science.
[77] René Bernards,et al. A Missing Link in Genotype-Directed Cancer Therapy , 2012, Cell.
[78] Rachael P. Huntley,et al. The UniProt-GO Annotation database in 2011 , 2011, Nucleic Acids Res..
[79] A. Barabasi,et al. Network biology: understanding the cell's functional organization , 2004, Nature Reviews Genetics.
[80] M. Kirschner,et al. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. , 1999, Science.
[81] A. Fraser,et al. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways , 2006, Nature Genetics.
[82] Wolfgang Huber,et al. Mapping of signaling networks through synthetic genetic interaction analysis by RNAi , 2011, Nature Methods.
[83] A. D’Andrea,et al. The USP1/UAF1 Complex Promotes Double-Strand Break Repair through Homologous Recombination , 2011, Molecular and Cellular Biology.
[84] J. Mesirov,et al. β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis , 2013, Cell.
[85] K. Kinzler,et al. Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells , 2009, Science.
[86] C. Obuse,et al. Proteomics analysis of the centromere complex from HeLa interphase cells: UV‐damaged DNA binding protein 1 (DDB‐1) is a component of the CEN‐complex, while BMI‐1 is transiently co‐localized with the centromeric region in interphase , 2004, Genes to cells : devoted to molecular & cellular mechanisms.
[87] A. Rose,et al. Synthetic Lethal Interactions Identify Phenotypic “Interologs” of the Spindle Assembly Checkpoint Components , 2007, Genetics.
[88] E. Lander,et al. The mystery of missing heritability: Genetic interactions create phantom heritability , 2012, Proceedings of the National Academy of Sciences.
[89] R. M. Simpson,et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression , 2010, Proceedings of the National Academy of Sciences.
[90] Sourav Bandyopadhyay,et al. Quantitative genetic-interaction mapping in mammalian cells , 2013, Nature Methods.
[91] R. Kolodner,et al. Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[92] The UniProt Consortium,et al. Reorganizing the protein space at the Universal Protein Resource (UniProt) , 2011, Nucleic Acids Res..
[93] M. Mann,et al. Proteomic characterization of the human centrosome by protein correlation profiling , 2003, Nature.
[94] Anne E Carpenter,et al. A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen , 2006, Cell.
[95] A. Alavi,et al. Akt Stimulates Aerobic Glycolysis in Cancer Cells , 2004, Cancer Research.
[96] J. Cheng,et al. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[97] Bert Vogelstein,et al. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21 , 1996, Nature.
[98] Carlota Oleaga,et al. Networking of differentially expressed genes in human cancer cells resistant to methotrexate , 2009, Genome Medicine.
[99] M. Nakafuku,et al. S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein , 1990, Cell.
[100] Gary D. Bader,et al. DRYGIN: a database of quantitative genetic interaction networks in yeast , 2009, Nucleic Acids Res..
[101] N. Carter,et al. Estimation of rearrangement phylogeny for cancer genomes. , 2012, Genome research.
[102] Michael J. Emanuele,et al. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene , 2009, Cell.
[103] Walter Kolch,et al. Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. , 2010, Cancer research.
[104] J. Moffat,et al. Off-target effects associated with long dsRNAs in Drosophila RNAi screens. , 2007, Trends in pharmacological sciences.
[105] Thomas M Green,et al. A public genome-scale lentiviral expression library of human ORFs , 2011, Nature Methods.
[106] Michael R. Speicher,et al. Securin Is Required for Chromosomal Stability in Human Cells , 2001, Cell.
[107] Benjamin J. Raphael,et al. Integrated Genomic Analyses of Ovarian Carcinoma , 2011, Nature.
[108] T. Waldman,et al. PTEN Gene Targeting Reveals a Radiation-Induced Size Checkpoint in Human Cancer Cells , 2004, Cancer Research.