Potential function for the Huntingtin protein as a scaffold for selective autophagy
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D. Housman | S. Finkbeiner | J. Marsh | D. Klionsky | L. Thompson | S. Humbert | F. Saudou | S. Zeitlin | J. Steffan | Kai Mao | T. Lukácsovich | Shuqiu Zheng | Alice L. Lau | Lisa Salazar | Joseph Ochaba | Julia Margulis | Sylvia Y. Yeung | G. Csikós | J. Ochaba | Diane E. Merry | Albert La Spada | Albert R. La Spada
[1] A. L. La Spada,et al. The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy. , 2014, Drug discovery today.
[2] S. Gygi,et al. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy , 2014, Nature.
[3] David A. Bennett,et al. REST and Stress Resistance in Aging and Alzheimer’s Disease , 2014, Nature.
[4] V. Promponas,et al. iLIR , 2014, Autophagy.
[5] R. Vierstra,et al. AUTOPHAGY-RELATED11 Plays a Critical Role in General Autophagy- and Senescence-Induced Mitophagy in Arabidopsis[W] , 2014, Plant Cell.
[6] E. Holzbaur,et al. The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation , 2014, The Journal of Neuroscience.
[7] D. Klionsky,et al. An overview of autophagy: morphology, mechanism, and regulation. , 2014, Antioxidants & redox signaling.
[8] G. Juhász,et al. Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila , 2014, Autophagy.
[9] Katharine H. Wrighton. Cytoskeleton: Autophagy and ciliogenesis come together , 2013, Nature Reviews Molecular Cell Biology.
[10] H. Simon,et al. ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy , 2013, Nature Communications.
[11] R. Truant,et al. Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin , 2013, Proceedings of the National Academy of Sciences.
[12] D. Klionsky,et al. The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy. , 2013, Developmental cell.
[13] R. Parker,et al. Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function , 2013, Cell.
[14] T. P. Neufeld,et al. ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase , 2013, Nature Cell Biology.
[15] John Calvin Reed,et al. Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging , 2013, Autophagy.
[16] S. Subramani,et al. Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11 , 2013, EMBO reports.
[17] F. Saudou,et al. Huntingtin’s Function in Axonal Transport Is Conserved in Drosophila melanogaster , 2013, PloS one.
[18] Kuninori Suzuki. Selective autophagy in budding yeast , 2012, Cell Death and Differentiation.
[19] J. Haber,et al. DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase , 2012, Proceedings of the National Academy of Sciences.
[20] P. Cossart,et al. Selective autophagy degrades DICER and AGO2 and regulates miRNA activity , 2012, Nature Cell Biology.
[21] Nima Ghitani,et al. A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis , 2012, Molecular Brain.
[22] S. Rikka,et al. Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy* , 2012, The Journal of Biological Chemistry.
[23] T. Lamark,et al. Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy , 2012, International journal of cell biology.
[24] R. Ferrante,et al. Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. , 2011, The Journal of clinical investigation.
[25] Benedikt Westermann,et al. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria , 2011, The Journal of cell biology.
[26] T. Saigusa,et al. Phosphorylation of Serine 114 on Atg32 mediates mitophagy , 2011, Molecular biology of the cell.
[27] Sebastian A. Wagner,et al. Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth , 2011, Science.
[28] M. MacDonald,et al. Deficiency of Huntingtin Has Pleiotropic Effects in the Social Amoeba Dictyostelium discoideum , 2011, PLoS genetics.
[29] C. Ross,et al. Huntington's disease: from molecular pathogenesis to clinical treatment , 2011, The Lancet Neurology.
[30] A. Rego,et al. Mitochondrial-associated metabolic changes and neurodegeneration in Huntington's disease - from clinical features to the bench. , 2010, Current drug targets.
[31] J. Steffan. Does Huntingtin play a role in selective macroautophagy? , 2010, Cell cycle.
[32] Kay Hofmann,et al. Selective autophagy: ubiquitin-mediated recognition and beyond , 2010, Nature Cell Biology.
[33] Yohanns Bellaiche,et al. Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis , 2010, Neuron.
[34] Elena Cattaneo,et al. Molecular mechanisms and potential therapeutical targets in Huntington's disease. , 2010, Physiological reviews.
[35] D. Sulzer,et al. CARGO RECOGNITION FAILURE IS RESPONSIBLE FOR INEFFICIENT AUTOPHAGY IN HUNTINGTON’S DISEASE , 2010, Nature Neuroscience.
[36] D. Rubinsztein,et al. Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice , 2010, PLoS genetics.
[37] S. Finkbeiner,et al. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome , 2009, The Journal of cell biology.
[38] S. Finkbeiner,et al. Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice , 2009, Neuron.
[39] C. Liang,et al. Neural-specific Deletion of FIP200 Leads to Cerebellar Degeneration Caused by Increased Neuronal Death and Axon Degeneration* , 2009, The Journal of Biological Chemistry.
[40] Ji Zhang,et al. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy , 2009, Cell Death and Differentiation.
[41] N. Perrimon,et al. Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington’s disease model , 2009, Disease Models & Mechanisms.
[42] Christian Pohl,et al. Midbody ring disposal by autophagy is a post-abscission event of cytokinesis , 2009, Nature Cell Biology.
[43] F. Inagaki,et al. Structural basis of target recognition by Atg8/LC3 during selective autophagy , 2008, Genes to cells : devoted to molecular & cellular mechanisms.
[44] R. Shiekhattar,et al. Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies , 2008, Proceedings of the National Academy of Sciences.
[45] D. Klionsky,et al. Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy , 2008, The Journal of cell biology.
[46] Antonia P. Sagona,et al. Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain , 2008, The Journal of cell biology.
[47] T. P. Neufeld,et al. Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. , 2007, Genes & development.
[48] R. Richards,et al. Huntingtin-deficient zebrafish exhibit defects in iron utilization and development. , 2007, Human molecular genetics.
[49] Danielle A. Simmons,et al. Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease , 2007, Glia.
[50] V. Sheffield,et al. A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis , 2007, Cell.
[51] Masaaki Komatsu,et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice , 2006, Nature.
[52] Hideyuki Okano,et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice , 2006, Nature.
[53] Alexei Degterev,et al. Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1* , 2006, Journal of Biological Chemistry.
[54] Jan Kassubek,et al. Thalamic atrophy in Huntington's disease co-varies with cognitive performance: a morphometric MRI analysis. , 2005, Cerebral cortex.
[55] D. Klionsky,et al. Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. , 2005, Molecular biology of the cell.
[56] E. Seeberg,et al. Mutant Huntingtin Impairs Axonal Trafficking in Mammalian Neurons In Vivo and In Vitro , 2004, Molecular and Cellular Biology.
[57] Fabrice P Cordelières,et al. Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules , 2004, Cell.
[58] Katarina Hattula,et al. FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis , 2000, Current Biology.
[59] Michael S. Levine,et al. Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice , 2000, Nature Genetics.
[60] Virginia E. Papaioannou,et al. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue , 1995, Nature Genetics.
[61] A. Joyner,et al. Inactivation of the mouse Huntington's disease gene homolog Hdh. , 1995, Science.
[62] S. Floresco,et al. Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes , 1995, Cell.
[63] M. Nakano,et al. Age-related changes in the lipofuscin accumulation of brain and heart. , 1995, Gerontology.
[64] S. Buck,et al. Selection for increased longevity in Drosophila melanogaster: a reply to Lints. , 1995, Gerontology.