High-flow-velocity and shear-rate imaging by use of color Doppler optical coherence tomography.

Color Doppler optical coherence tomography (CDOCT) is capable of precise velocity mapping in turbid media. Previous CDOCT systems based on the short-time Fourier transform have been limited to maximum flow velocities of the order of tens of millimeters per second. We describe a technique, based on interference signal demodulation at multiple frequencies, to extend the physiological relevance of CDOCT by increasing the dynamic range of measurable velocities to hundreds of millimeters per second. The physiologically important parameter of shear rate is also derived from CDOCT measurements. The measured flow-velocity profiles and shear-rate distributions correlate very well with theoretical predictions. The multiple demodulation technique, therefore, may be useful to monitor blood flow in vivo and to identify regions with high and low shear rates.

[1]  P. Serruys,et al.  Evaluation of endothelial shear stress and 3D geometry as factors determining the development of atherosclerosis and remodeling in human coronary arteries in vivo. Combining 3D reconstruction from angiography and IVUS (ANGUS) with computational fluid dynamics. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[2]  G. Hutchins,et al.  Shear-dependent thickening of the human arterial intima. , 1986, Atherosclerosis.

[3]  J. Izatt,et al.  High resolution imaging of in vivo cardiac dynamics using color Doppler optical coherence tomography. , 1997, Optics express.

[4]  J. Izatt,et al.  Optical coherence microscopy in gastrointestinal tissues , 1996, Summaries of papers presented at the Conference on Lasers and Electro-Optics.

[5]  J. Izatt,et al.  In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography. , 1997, Optics letters.

[6]  B. Kuban,et al.  The effect of pulsatile frequency on wall shear in a compliant cast of a human aortic bifurcation. , 1995, Journal of biomechanical engineering.

[7]  J. Izatt,et al.  Velocity-estimation accuracy and frame-rate limitations in color Doppler optical coherence tomography. , 1998, Optics letters.

[8]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[9]  Zhongping Chen,et al.  Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media. , 1997, Optics letters.

[10]  M. V. van Gemert,et al.  Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. , 1997, Optics letters.

[11]  R S Reneman,et al.  A noninvasive method to estimate wall shear rate using ultrasound. , 1995, Ultrasound in medicine & biology.

[12]  Joseph A. Izatt,et al.  Ophthalmic diagnostics using optical coherence tomography , 1993, Photonics West - Lasers and Applications in Science and Engineering.