Hypolipidemic Effects of Ethanolic and Aqueous Extracts of Urtica Dioica in Rats

Lipid profile changes can be seen in metabolic syndrome and especially diabetes mellitus. The aim of this investigation is to assess the effect of ethanolic and aqueous leave extracts of this plant on serum lipid level in diabetic animal model. This study was carried out on 45 Wistar rats randomly distributed in 3 groups rats. Treatment groups received 150 mg/kg of alloxan intraperitoneally. Then rats were fed ethanolic and aqueous extracts of Urtica dioica leave in 50 mg/kg/day doses, for two weeks. After treatment, the serum lipids level were measured. Our studies showed significantly lower levels of triglyceride, cholesterol, LDL-C in both of groups of rats that were treated with ethanolic or aqueous extracts of leave Urtica dioica as compared with the control group of rat,( p<0.05). The results of this study suggest that Urtica dioica leave extracts improve lipid tolerance in alloxan induced diabetic rat.

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