A flavonoid fraction purified from Rutaceae aurantiae (Daflon(R)) inhibiting AGE formation, reduces urinary albumin clearance and corrects hypoalbuminemia in normotensive and hypertensive diabetic rats.

[1]  B. Li,et al.  An in vivo and in vitro study , 2016, Human & experimental toxicology.

[2]  Xiaofeng Yu,et al.  Protective effect of total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack on diabetic nephropathy in rats. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[3]  A. Ozmen,et al.  Beneficial effect of myricetin on renal functions in streptozotocin-induced diabetes , 2012, Clinical and Experimental Medicine.

[4]  M. Moridani,et al.  Renoprotective effects of (+)-catechin in streptozotocin-induced diabetic rat model. , 2012, Nutrition research.

[5]  W. Krzyściak,et al.  Oxidative DNA Damage in Blood of CVD Patients Taking Detralex , 2011, The open cardiovascular medicine journal.

[6]  S. Srinivasan,et al.  Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. , 2010, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[7]  M. Mohan,et al.  Effect of myricetin on blood pressure and metabolic alterations in fructose hypertensive rats , 2010, Pharmaceutical biology.

[8]  Andrew G Mercader,et al.  QSAR prediction of inhibition of aldose reductase for flavonoids. , 2008, Bioorganic & medicinal chemistry.

[9]  M. Bronze,et al.  Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones. , 2008, Bioorganic & medicinal chemistry.

[10]  E. Bouskela,et al.  Different flavonoids present in the micronized purified flavonoid fraction (Daflon 500 mg) contribute to its anti-hyperpermeability effect in the hamster cheek pouch microcirculation. , 2008, International angiology : a journal of the International Union of Angiology.

[11]  P. Urios,et al.  Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure , 2007, European journal of nutrition.

[12]  K Szentmihályi,et al.  The effect of citrus flavonoids on the redox state of alimentary-induced fatty liver in rats , 2007, Natural product research.

[13]  M. Sternberg,et al.  Advanced glycation endproducts (AGEs): Pharmacological inhibition in diabetes. , 2006, Pathologie-biologie.

[14]  I. Niopas,et al.  A validated HPLC determination of the flavone aglycone diosmetin in human plasma. , 2004, Biomedical chromatography : BMC.

[15]  R. Wu,et al.  Oxidative Stress in Hypertension , 2004, Clinical and experimental hypertension.

[16]  S. Pani,et al.  Some observations on the effect of Daflon (micronized purified flavonoid fraction of Rutaceae aurantiae) in bancroftian filarial lymphoedema , 2003, Filaria journal.

[17]  S. Menini,et al.  Comparative trial of N-acetyl-cysteine, taurine, and oxerutin on skin and kidney damage in long-term experimental diabetes. , 2003, Diabetes.

[18]  S. Genuth,et al.  Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Collagen Ancillary Study Group. Diabetes Contro , 1999, Diabetes.

[19]  G. Jerums,et al.  Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic rats , 1997, Diabetologia.

[20]  M. Attalah,et al.  Effects of a Purified Micronized Flavonoid Fraction on Capillary Filtration in Diabetic Patients , 1996, Diabetic medicine : a journal of the British Diabetic Association.

[21]  A. Colantuoni,et al.  Effects of the natural flavonoid delphinidin on diabetic microangiopathy. , 1995, Arzneimittel-Forschung.

[22]  Yong Ming Li,et al.  Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[23]  A. McElduff,et al.  Diabetes Control and Complications Trial , 1993 .

[24]  V. Monnier,et al.  Pentosidine Formation in Skin Correlates With Severity of Complications in Individuals With Long-Standing IDDM , 1992, Diabetes.

[25]  H. Hammes,et al.  Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[26]  L. Perdrix,et al.  Protective effect of a purified flavonoid fraction against reactive oxygen radicals. In vivo and in vitro study. , 1989, Arzneimittel-Forschung.

[27]  G. Lagrue,et al.  Study of capillary filtration by double labelling I131-albumin and Tc99m red cells. Application to the pharmacodynamic activity of Daflon 500 mg. , 1988, International angiology : a journal of the International Union of Angiology.

[28]  J. Farjanel,et al.  Aorta collagen metabolism in spontaneously hypertensive and aortic-constricted rats: variations in enzyme activities concerned with disaccharide unit synthesis and degradation according to blood pressure and age. , 1985, Collagen and related research.

[29]  A. Beyer-Mears,et al.  Reversal of Diabetic Cataract by Sorbinil, an Aldose Reductase Inhibitor , 1985, Diabetes.

[30]  J. Borel,et al.  Evaluation of the hydroxyproline isomers in blood serum. , 1984, Clinica chimica acta; international journal of clinical chemistry.

[31]  R. Spiro,et al.  Studies on the catabolism of the hydroxylysine-linked disaccharide units of basement membranes and collagens. Isolation and characterization of a rat kidney alpha-glucosidase of high specificity. , 1979, The Journal of biological chemistry.

[32]  G. W. Snedecor STATISTICAL METHODS , 1967 .

[33]  J. F. Woessner,et al.  The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. , 1961, Archives of biochemistry and biophysics.

[34]  A. Nemeikaitė-Čėnienė,et al.  Correlation between mammalian cell cytotoxicity of flavonoids and the redox potential of phenoxyl radical/phenol couple. , 2012, Acta biochimica Polonica.

[35]  V. Leblond,et al.  Production of type IV collagen and 72-kDa gelatinase by human endothelial cells cultured in high glucose. Effects of a protein kinase C inhibitor, GF 109203X. , 1996, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[36]  H. Hammes,et al.  Erratum: Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy (Proc. Natl. Acad. Sci. USA (December 15, 1991) 88:24 (11555-11558)) , 1992 .

[37]  Gert E. Nilsson,et al.  A New Instrument for Continuous Measurement of Tissue Blood Flow by Light Beating Spectroscopy , 1980, IEEE Transactions on Biomedical Engineering.