Comparative proteomic analysis of insulin receptor isoform A and B signaling

[1]  A. Belfiore,et al.  IFN-I signaling in cancer: the connection with dysregulated Insulin/IGF axis , 2022, Trends in Endocrinology & Metabolism.

[2]  A. Pulvirenti,et al.  Novel Mechanisms of Tumor Promotion by the Insulin Receptor Isoform A in Triple-Negative Breast Cancer Cells , 2021, Cells.

[3]  Anoop Misra,et al.  Differential expression of insulin receptor substrate-1(IRS-1) in visceral and subcutaneous adipose depots of morbidly obese subjects undergoing bariatric surgery in a tertiary care center in north India; SNP analysis and correlation with metabolic profile. , 2021, Diabetes & metabolic syndrome.

[4]  P. Paoli,et al.  Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment , 2020, Cancers.

[5]  Catherin Hall,et al.  Insulin receptor endocytosis in the pathophysiology of insulin resistance , 2020, Experimental & Molecular Medicine.

[6]  Zhi-Yong Wang,et al.  Down-Regulation of Ribosomal Protein RPS21 Inhibits Invasive Behavior of Osteosarcoma Cells Through the Inactivation of MAPK Pathway , 2020, Cancer management and research.

[7]  S. O’Rahilly,et al.  Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure , 2020, Molecular metabolism.

[8]  P. Fan,et al.  GNG12 regulates PD‐L1 expression by activating NF‐κB signaling in pancreatic ductal adenocarcinoma , 2020, FEBS open bio.

[9]  Chasity E Trammell,et al.  Emerging Mechanisms of Insulin-Mediated Antiviral Immunity in Drosophila melanogaster , 2019, Front. Immunol..

[10]  W. Birchmeier,et al.  SHP-2 in Lymphocytes' Cytokine and Inhibitory Receptor Signaling , 2019, Front. Immunol..

[11]  Zhiqin Gao,et al.  Identification of candidate diagnostic and prognostic biomarkers for human prostate cancer: RPL22L1 and RPS21 , 2019, Medical Oncology.

[12]  G. Fadini,et al.  Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc , 2019, International journal of molecular sciences.

[13]  N. Galjart,et al.  Distinct Functions for Mammalian CLASP1 and -2 During Neurite and Axon Elongation , 2019, Front. Cell. Neurosci..

[14]  C. Kahn,et al.  Insulin receptor plays a central role in skin carcinogenesis by regulating cytoskeleton assembly , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[15]  W. Qian,et al.  Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation , 2018, Molecular metabolism.

[16]  C. Kahn,et al.  Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action. , 2018, Cellular signalling.

[17]  A. Belfiore,et al.  A novel functional crosstalk between DDR1 and the IGF axis and its relevance for breast cancer , 2018, Cell adhesion & migration.

[18]  W. Huber,et al.  Proteome-wide identification of ubiquitin interactions using UbIA-MS , 2018, Nature Protocols.

[19]  M. Lawrence,et al.  Insulin Receptor Isoforms in Physiology and Disease: An Updated View , 2017, Endocrine reviews.

[20]  P. Vigneri,et al.  Discoidin domain receptor 1 modulates insulin receptor signaling and biological responses in breast cancer cells , 2017, Oncotarget.

[21]  Han Han,et al.  Angiomotin-like 2 interacts with and negatively regulates AKT , 2017, Oncogene.

[22]  A. McMahon,et al.  Hedgehog Signaling: From Basic Biology to Cancer Therapy. , 2017, Cell chemical biology.

[23]  Ji-yeon Lee,et al.  The mitotic checkpoint regulator RAE1 induces aggressive breast cancer cell phenotypes by mediating epithelial-mesenchymal transition , 2017, Scientific Reports.

[24]  Y. Endo,et al.  CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. , 2017, Cell reports.

[25]  B. Potter,et al.  SHIP2: Structure, Function and Inhibition , 2017, Chembiochem : a European journal of chemical biology.

[26]  N. Perrimon,et al.  An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling. , 2016, Cell reports.

[27]  D. Yee,et al.  EMT reversal in human cancer cells after IR knockdown in hyperinsulinemic mice. , 2016, Endocrine-related cancer.

[28]  Fandi Meng,et al.  XB130: A novel adaptor protein in cancer signal transduction. , 2016, Biomedical reports.

[29]  K. Ramaiah,et al.  Insulin treatment promotes tyrosine phosphorylation of PKR and inhibits polyIC induced PKR threonine phosphorylation. , 2015, Archives of biochemistry and biophysics.

[30]  Marco Y. Hein,et al.  mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3 , 2015, Nature Communications.

[31]  A. Avogaro,et al.  p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans , 2015, Diabetologia.

[32]  A. Lavecchia,et al.  Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion , 2015, Oncotarget.

[33]  H. Zhe,et al.  The emerging role of CaMKII in cancer , 2015, Oncotarget.

[34]  Xiang Zhou,et al.  Ribosomal proteins: functions beyond the ribosome. , 2015, Journal of molecular cell biology.

[35]  R. Iozzo,et al.  Novel cross-talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses , 2015, Oncotarget.

[36]  A. Belfiore,et al.  The Emerging Role of Insulin and Insulin-Like Growth Factor Signaling in Cancer Stem Cells , 2014, Front. Endocrinol..

[37]  V. Elner,et al.  Tissue-Based Microarray Expression of Genes Predictive of Metastasis in Uveal Melanoma and Differentially Expressed in Metastatic Uveal Melanoma , 2013, Journal of ophthalmic & vision research.

[38]  H. Fu,et al.  RPS12-specific shRNA inhibits the proliferation, migration of BGC823 gastric cancer cells with S100A4 as a downstream effector. , 2013, International journal of oncology.

[39]  H. Bussemaker,et al.  Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. , 2012, Molecular cell.

[40]  M. White,et al.  Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 , 2012, Diabetologia.

[41]  M. Holliday,et al.  Attenuated Pik3r1 Expression Prevents Insulin Resistance and Adipose Tissue Macrophage Accumulation in Diet-Induced Obese Mice , 2012, Diabetes.

[42]  A. Belfiore,et al.  Proinsulin binds with high affinity the insulin receptor isoform A and predominantly activates the mitogenic pathway. , 2012, Endocrinology.

[43]  A. Belfiore,et al.  The Insulin Receptor: A New Target for Cancer Therapy , 2011, Front. Endocrin..

[44]  A. Belfiore,et al.  Insulin receptor and cancer. , 2011, Endocrine-related cancer.

[45]  M. Larsen,et al.  Research resource: New and diverse substrates for the insulin receptor isoform A revealed by quantitative proteomics after stimulation with IGF-II or insulin. , 2011, Molecular endocrinology.

[46]  A. Belfiore,et al.  Insulin receptor isoforms and insulin-like growth factor receptor in human follicular cell precursors from papillary thyroid cancer and normal thyroid. , 2011, The Journal of clinical endocrinology and metabolism.

[47]  T. Prolla,et al.  The Shc locus regulates insulin signaling and adiposity in mammals , 2011, Aging cell.

[48]  M. Shibuya,et al.  RACK1 Regulates VEGF/Flt1-mediated Cell Migration via Activation of a PI3K/Akt Pathway* , 2011, The Journal of Biological Chemistry.

[49]  Katsuo Suzuki,et al.  WAVE2 targeting to phosphatidylinositol 3,4,5-triphosphate mediated by insulin receptor substrate p53 through a complex with WAVE2. , 2010, Cellular signalling.

[50]  J. Wands,et al.  The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling. , 2010, Biochemical and biophysical research communications.

[51]  M. Illario,et al.  The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC. , 2010, Endocrine-related cancer.

[52]  Ola Larsson,et al.  The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis , 2009, Proceedings of the National Academy of Sciences.

[53]  J. Tanti,et al.  Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. , 2009, Current opinion in pharmacology.

[54]  Sean M. Hartig,et al.  The Cdc42-interacting Protein-4 (CIP4) Gene Knock-out Mouse Reveals Delayed and Decreased Endocytosis* , 2009, The Journal of Biological Chemistry.

[55]  M. Reilly,et al.  Interferon γ Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway* , 2009, Journal of Biological Chemistry.

[56]  A. Belfiore,et al.  Differential signaling activation by insulin and insulin-like growth factors I and II upon binding to insulin receptor isoform A. , 2009, Endocrinology.

[57]  F. Frasca,et al.  TAp73α Increases p53 Tumor Suppressor Activity in Thyroid Cancer Cells via the Inhibition of Mdm2-Mediated Degradation , 2008, Molecular Cancer Research.

[58]  Shaun P Jackson,et al.  Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. , 2007, The Biochemical journal.

[59]  Kristian Helin,et al.  The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation , 2007, Molecular and Cellular Biology.

[60]  A. Belfiore The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer. , 2007, Current pharmaceutical design.

[61]  B. Neel,et al.  The role of Shp2 (PTPN11) in cancer. , 2007, Current opinion in genetics & development.

[62]  M. Kanzaki Insulin receptor signals regulating GLUT4 translocation and actin dynamics. , 2006, Endocrine journal.

[63]  Lei Xu,et al.  GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[64]  Robbie Loewith,et al.  A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling , 2006, Cell.

[65]  A. Merdes,et al.  NEDD1-dependent recruitment of the γ-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly , 2006, The Journal of cell biology.

[66]  M. Vinciguerra,et al.  PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signalling , 2006, Archives of physiology and biochemistry.

[67]  L. Cantley,et al.  Then Negative Regulation of Phosphoinositide 3-Kinase Signaling by p85 and Its Implication in Cancer , 2005 .

[68]  R. O'Connor,et al.  RACK1-mediated Integration of Adhesion and Insulin-like Growth Factor I (IGF-I) Signaling and Cell Migration Are Defective in Cells Expressing an IGF-I Receptor Mutated at Tyrosines 1250 and 1251* , 2005, Journal of Biological Chemistry.

[69]  J. Engelman,et al.  Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice , 2005, Molecular and Cellular Biology.

[70]  K. Siminovitch,et al.  Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[71]  E. Medico,et al.  IGF‐II Binding to Insulin Receptor Isoform A Induces a Partially Different Gene Expression Profile from Insulin Binding , 2004, Annals of the New York Academy of Sciences.

[72]  Andrea Disanza,et al.  Abi1 is essential for the formation and activation of a WAVE2 signalling complex , 2004, Nature Cell Biology.

[73]  A. Wernig,et al.  Muscle Regeneration and Myogenic Differentiation Defects in Mice Lacking TIS7 , 2004, Molecular and Cellular Biology.

[74]  K. Rottner,et al.  Sra‐1 and Nap1 link Rac to actin assembly driving lamellipodia formation , 2004, The EMBO journal.

[75]  P. Berggren,et al.  Isoform-specific insulin receptor signaling involves different plasma membrane domains , 2003, Journal of Cell Biology.

[76]  E. Medico,et al.  Differential Gene Expression Induced by Insulin and Insulin-like Growth Factor-II through the Insulin Receptor Isoform A* , 2003, Journal of Biological Chemistry.

[77]  M. Crow,et al.  Interaction of Filamin A with the Insulin Receptor Alters Insulin-dependent Activation of the Mitogen-activated Protein Kinase Pathway* , 2003, Journal of Biological Chemistry.

[78]  L. Blanchoin,et al.  Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. , 2003, Molecular cell.

[79]  A. Belfiore,et al.  In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A , 2002, Oncogene.

[80]  A. Belfiore,et al.  Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved* , 2002, The Journal of Biological Chemistry.

[81]  A. Saltiel,et al.  The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[82]  Alexandre V. Podtelejnikov,et al.  Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck , 2002, Nature.

[83]  Weiqun Li,et al.  RACK1, an Insulin-Like Growth Factor I (IGF-I) Receptor-Interacting Protein, Modulates IGF-I-Dependent Integrin Signaling and Promotes Cell Spreading and Contact with Extracellular Matrix , 2002, Molecular and Cellular Biology.

[84]  Kohjiro Ueki,et al.  Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[85]  A. Diefenbach,et al.  Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity , 2001, Nature.

[86]  A. Costantino,et al.  Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells , 1999, Molecular and Cellular Biology.

[87]  A. Klip,et al.  Opposite effects of insulin on focal adhesion proteins in 3T3-L1 adipocytes and in cells overexpressing the insulin receptor. , 1998, Molecular biology of the cell.

[88]  K. Siddle,et al.  Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. , 1998, The Biochemical journal.

[89]  A. Kosaki,et al.  Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells. , 1993, The Journal of biological chemistry.

[90]  J. Baker,et al.  Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) , 1993, Cell.

[91]  J. Flier,et al.  Ligand-binding properties of the two isoforms of the human insulin receptor. , 1993, Endocrinology.

[92]  J. Flier,et al.  Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells. , 1991, Endocrinology.

[93]  A. Ullrich,et al.  The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics. , 1991, Biochemical and biophysical research communications.

[94]  A. Ullrich,et al.  Functionally distinct insulin receptors generated by tissue‐specific alternative splicing. , 1990, The EMBO journal.

[95]  J. Flier,et al.  Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. , 1989, Molecular endocrinology.

[96]  G. Bell,et al.  Alternative splicing of human insulin receptor messenger RNA. , 1989, Biochemical and biophysical research communications.

[97]  C. Weigert,et al.  Divergent Roles of IRS (Insulin Receptor Substrate) 1 and 2 in Liver and Skeletal Muscle. , 2017, Current medicinal chemistry.

[98]  Thaddeus S Block,et al.  The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness , 2017, The Journal of Steroid Biochemistry and Molecular Biology.

[99]  G. Benedetto,et al.  TRANSCRIPTIONAL AND PHOSPHO-PROTEOMIC SCREENS REVEAL STEM CELL ACTIVATION OF INSULIN-RESISTANCE AND TRANSFORMATION PATHWAYS FOLLOWING A SINGLE MINIMALLY TOXIC EPISODE OF ROS. , 2011, International journal of genomics and proteomics.

[100]  Steven Y. Cheng,et al.  Role and regulation of human tumor suppressor SUFU in Hedgehog signaling. , 2008, Advances in cancer research.

[101]  M. Mann,et al.  Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips , 2007, Nature Protocols.

[102]  A. Belfiore,et al.  A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer. , 2002, The Journal of clinical endocrinology and metabolism.