Oral Steroid Treatment of Sudden Sensorineural Hearing Loss: A Ten Year Retrospective Analysis

Objective To describe ten years of experience with Sudden Sensorineural Hearing Loss and compare the outcomes with and without treatment with oral corticosteroids. Study Design Retrospective review of medical records. Setting Large specialty hospital, Department of Otolaryngology. Patients Patients presenting with sudden onset (72 hours) unilateral sensorineural hearing loss, with no evidence of Ménière's Disease, acoustic injury, retrocochlear disease, and other specifiable disorders. Interventions The majority of patients received a standard course of oral corticosteroids (Prednisone 60mg and taper). A smaller group declined treatment. Main Outcome Measures Recovery of hearing sensitivity was measured using standard audiometry and reported as change in Pure Tone Average. Word recognition scores were also analyzed. Results When severe-to-profound cases are analyzed, a significant improvement (p < .01) in Pure Tone Average is seen in cases treated with steroids versus those untreated. When milder cases are included, a statistical floor effect prevents differentiation of these groups. Word recognition scores were significantly improved (p < .05) in the treated group. Conclusions Application of steroid medication significantly improves the recovery outcomes in cases of Severe Sudden Sensorineural Hearing Loss.

[1]  D. Tucci,et al.  Treatment of Sudden Sensorineural Hearing Loss with Systemic Steroids and Valacyclovir , 2002, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[2]  Joe C. Adams,et al.  Clinical Implications of Inflammatory Cytokines in the Cochlea: A Technical Note , 2002, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[3]  J. Kronenberg,et al.  Steroids, carbogen or placebo for sudden hearing loss: a prospective double-blind study , 2001, European Archives of Oto-Rhino-Laryngology.

[4]  M. Hoffer,et al.  Targeted Topical Steroid Therapy in Sudden Sensorineural Hearing Loss , 2001, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[5]  W. Arnold,et al.  Sudden sensorineural hearing loss: does application of glucocorticoids make sense? , 2001, Archives of otolaryngology--head & neck surgery.

[6]  R. Minoda,et al.  Initial steroid hormone dose in the treatment of idiopathic sudden deafness. , 2000, The American journal of otology.

[7]  T. Nakashima,et al.  Clinicoepidemiologic Features of Sudden Deafness Diagnosed and Treated at University Hospitals in Japan , 2000, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[8]  D. Tucci.  Sudden sensorineural hearing loss: a viral etiology? , 2000, Archives of otolaryngology--head & neck surgery.

[9]  G. Gianoli,et al.  Transtympanic Steroids for Treatment of Sudden Hearing Loss , 1999, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[10]  L. Parnes,et al.  Corticosteroid Pharmacokinetics in the Inner Ear Fluids: An Animal Study Followed by Clinical Application , 1999, The Laryngoscope.

[11]  P. Laippala,et al.  Sudden Deafness: A Comparison of Anticoagulant Therapy and Carbogen Inhalation Therapy , 1997, The Annals of otology, rhinology, and laryngology.

[12]  J. Saunders,et al.  Prognosis and treatment of sudden sensorineural hearing loss. , 1996, The American journal of otology.

[13]  G. Darmstadt,et al.  Luetic hearing loss: clinical presentation, diagnosis, and treatment. , 1989, American journal of otolaryngology.

[14]  T. Stijnen,et al.  HERPES-VIRUS IMMUNITY AND ACUTE GRAFT-VERSUS-HOST DISEASE , 1987, The Lancet.

[15]  W. Wilson.  The Relationship of the Herpesvirus Family to Sudden Hearing Loss: A Prospective Clinical Study and Literature Review , 1986, The Laryngoscope.

[16]  D. Richman,et al.  Hearing Loss in Experimental Cytomegalovirus Infection of the Guinea Pig Inner Ear: Prevention by Systemic Immunity , 1985, The Annals of otology, rhinology, and laryngology.

[17]  F. Byl.  Sudden hearing loss: Eight years' experience and suggested prognostic table , 1984, The Laryngoscope.

[18]  R. Veltri,et al.  Viral and Epidemiologic Studies of Idiopathic Sudden Hearing Loss , 1983, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[19]  R. Veltri,et al.  The Implication of Viruses in Idiopathic Sudden Hearing Loss: Primary Infection or Reactivation of Latent Viruses? , 1981, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[20]  F. Byl,et al.  The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. , 1980, Archives of otolaryngology.

[21]  A. Thornton,et al.  Speech-discrimination scores modeled as a binomial variable. , 1978, Journal of speech and hearing research.

[22]  B. Jaffe.  Viral causes of sudden inner ear deafness. , 1978, Otolaryngologic clinics of North America.

[23]  F. B. Simmons,et al.  Natural History of Sudden Sensorineural Hearing Loss , 1977, The Annals of otology, rhinology, and laryngology.

[24]  J. Sheehy,et al.  Sudden sensori‐neural hearing impairment: A report of 1,220 cases , 1976, The Laryngoscope.

[25]  D. R. Gamble,et al.  A VIROLOGICAL AND EPIDEMIOLOGICAL STUDY OF PATIENTS WITH ACUTE HEARING LOSS , 1975, The Lancet.

[26]  F. B. Simmons,et al.  Sudden idiopathic sensori-neural hearing loss: some observations. , 1973, The Laryngoscope.

[27]  H. Schuknecht,et al.  The pathology of sudden deafness. , 1973, Acta oto-laryngologica.

[28]  Y. Guerrier,et al.  [Management of sudden deafness]. , 1969, Journal francais d'oto-rhino-laryngologie, audio-phonologie et chirurgie maxillo-faciale.

[29]  J. Jerger,et al.  Preferred Method For Clinical Determination Of Pure-Tone Thresholds , 1959 .

[30]  C. Fernández,et al.  EXPERIMENTS ON TEMPORARY OBSTRUCTION OF THE INTERNAL AUDITORY ARTERY. , 1959, The Laryngoscope.

[31]  H. van Dishoeck,et al.  LXXIII Sudden Perceptive Deafness and Viral Infection , 1957 .

[32]  I. Hirsh,et al.  Development of materials for speech audiometry. , 1952, The Journal of speech and hearing disorders.

[33]  H. Schuknecht,et al.  The pathology of idiopathic sudden sensorineural hearing loss , 2004, Archives of oto-rhino-laryngology.

[34]  M. Bolzan,et al.  Epidemiological considerations in sudden hearing loss: a study of 183 cases , 2004, Archives of oto-rhino-laryngology.

[35]  E. Laurikainen,et al.  A follow-up study of patients suffering from sudden sensorineural hearing loss. , 2001, Acta oto-laryngologica.

[36]  R. Stokroos,et al.  Antiviral treatment of idiopathic sudden sensorineural hearing loss: a prospective, randomized, double-blind clinical trial. , 1998, Acta oto-laryngologica.

[37]  J. Kanzaki,et al.  Estimated annual number of patients treated for sensorineural hearing loss in Japan. Results of a nationwide epidemiological survey in 1987. , 1994, Acta oto-laryngologica. Supplementum.

[38]  Mattox De,et al.  Idiopathic sudden sensorineural hearing loss. , 1989, The American journal of otology.

[39]  H. Fletcher,et al.  A method of calculating hearing loss for speech from an audiogram. , 1950, Acta oto-laryngologica. Supplementum.

[40]  Harvey Fletcher,et al.  A Method of Calculating Hearing Loss for Speech from an Audiogram , 1950 .

[41]  A. D. Kleyn,et al.  Sudden complete or partial loss of function of the octavus-system in apparently normal persons , 1944 .