Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy.

The advancement of biocompatible nanoplatforms with dual functionalities of diagnosis and therapeutics has been strongly demanded in biomedicine in recent years. In this work, we report the synthesis and characterization of polydopamine (pD)-coated gold nanostars (Au NSs) for computed tomography (CT) imaging and enhanced photothermal therapy (PTT) of tumors. Au NSs were firstly formed via a seed-mediated growth method and then stabilized with thiolated polyethyleneimine (PEI-SH), followed by deposition of pD on their surface. The formed pD-coated Au NSs (Au-PEI@pD NSs) were well characterized. We show that the Au-PEI@pD NSs are able to convert the absorbed near-infrared laser light into heat, and have strong X-ray attenuation properties. Due to the co-existence of Au NSs and pD, the light to heat conversion efficiency of the NSs can be significantly enhanced. These very interesting properties allow them to be used as a powerful theranostic nanoplatform for efficient CT imaging and enhanced phtotothermal therapy of cancer cells in vitro and the xenografted tumor model in vivo. Due to their easy functionalization nature enabled by the coated pD shell, the developed pD-coated Au NSs may be used as a versatile nanoplatform for targeted CT imaging and PTT of different types of cancers.

[1]  Jong Seung Kim,et al.  Small conjugate-based theranostic agents: an encouraging approach for cancer therapy. , 2015, Chemical Society reviews.

[2]  Xiangyang Shi,et al.  Dendrimer-entrapped metal colloids as imaging agents. , 2015, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[3]  Shailesh N Mistry,et al.  Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand. , 2015, Journal of medicinal chemistry.

[4]  Haeshin Lee,et al.  Role of Dopamine Chemistry in the Formation of Mechanically Strong Mandibles of Grasshoppers , 2015 .

[5]  J. Cheon,et al.  Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy. , 2015, Chemical reviews.

[6]  K. Wooley,et al.  Polymeric Nanostructures for Imaging and Therapy. , 2015, Chemical reviews.

[7]  Chao Zhang,et al.  Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy. , 2015, Chemical reviews.

[8]  Hakho Lee,et al.  Nanostar Clustering Improves the Sensitivity of Plasmonic Assays. , 2015, Bioconjugate chemistry.

[9]  Tuan Vo-Dinh,et al.  A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy , 2015, Theranostics.

[10]  Hao Zhang,et al.  Hydroquinone-assisted synthesis of branched au-ag nanoparticles with polydopamine coating as highly efficient photothermal agents. , 2015, ACS applied materials & interfaces.

[11]  W. Tan,et al.  Silver nanoparticle gated, mesoporous silica coated gold nanorods (AuNR@MS@AgNPs): low premature release and multifunctional cancer theranostic platform. , 2015, ACS applied materials & interfaces.

[12]  M. Houška,et al.  Self-assembled anchor layers/polysaccharide coatings on titanium surfaces: a study of functionalization and stability , 2015, Beilstein journal of nanotechnology.

[13]  Scott G. Mitchell,et al.  Dissecting the molecular mechanism of apoptosis during photothermal therapy using gold nanoprisms. , 2015, ACS nano.

[14]  Shuping Xu,et al.  A silica-gold-silica nanocomposite for photothermal therapy in the near-infrared region. , 2015, ACS applied materials & interfaces.

[15]  Yong Hu,et al.  Hyaluronic acid-modified Fe3O4@Au core/shell nanostars for multimodal imaging and photothermal therapy of tumors. , 2015, Biomaterials.

[16]  Eun Seong Lee,et al.  Y-shaped ligand-driven gold nanoparticles for highly efficient tumoral uptake and photothermal ablation. , 2014, ACS nano.

[17]  Donghong Zhao,et al.  Neural Stem Cell-Mediated Intratumoral Delivery of Gold Nanorods Improves Photothermal Therapy , 2014, ACS nano.

[18]  A. Concheiro,et al.  Targeted Combinatorial Therapy Using Gold Nanostars as Theranostic Platforms , 2014 .

[19]  Lidong Li,et al.  Fluorescent organic nanoparticles with enhanced fluorescence by self-aggregation and their application to cellular imaging. , 2014, ACS applied materials & interfaces.

[20]  Mingwu Shen,et al.  Multifunctional PEGylated Multiwalled Carbon Nanotubes for Enhanced Blood Pool and Tumor MR Imaging , 2014, Advanced healthcare materials.

[21]  Mingwu Shen,et al.  Synthesis and characterization of PEGylated polyethylenimine-entrapped gold nanoparticles for blood pool and tumor CT imaging. , 2014, ACS applied materials & interfaces.

[22]  Xiaolong Liu,et al.  Lipid-AuNPs@PDA nanohybrid for MRI/CT imaging and photothermal therapy of hepatocellular carcinoma. , 2014, ACS applied materials & interfaces.

[23]  Ben Wang,et al.  A strong integrated strength and toughness artificial nacre based on dopamine cross-linked graphene oxide. , 2014, ACS nano.

[24]  Mingwu Shen,et al.  Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles. , 2014, Biomaterials.

[25]  Hao Hong,et al.  Positron Emission Tomography Image-Guided Drug Delivery: Current Status and Future Perspectives , 2014, Molecular pharmaceutics.

[26]  Wei Lu,et al.  Combinatorial Photothermal and Immuno Cancer Therapy Using Chitosan-Coated Hollow Copper Sulfide Nanoparticles , 2014, ACS nano.

[27]  J. Ji,et al.  Multidentate polyethylene glycol modified gold nanorods for in vivo near-infrared photothermal cancer therapy. , 2014, ACS applied materials & interfaces.

[28]  Hao Zhang,et al.  Polypyrrole-coated chainlike gold nanoparticle architectures with the 808 nm photothermal transduction efficiency up to 70%. , 2014, ACS applied materials & interfaces.

[29]  Huang-Hao Yang,et al.  Multifunctional Fe₃O₄@polydopamine core-shell nanocomposites for intracellular mRNA detection and imaging-guided photothermal therapy. , 2014, ACS nano.

[30]  Sang Cheon Lee,et al.  Polydopamine-based simple and versatile surface modification of polymeric nano drug carriers. , 2014, ACS nano.

[31]  Lingxin Chen,et al.  Upconversion fluorescence-SERS dual-mode tags for cellular and in vivo imaging. , 2014, ACS applied materials & interfaces.

[32]  Manuel Alatorre-Meda,et al.  Fluorescent drug-loaded, polymeric-based, branched gold nanoshells for localized multimodal therapy and imaging of tumoral cells. , 2014, ACS nano.

[33]  W. Peukert,et al.  Shedding light on the growth of gold nanoshells. , 2014, ACS nano.

[34]  Rizia Bardhan,et al.  Emerging advances in nanomedicine with engineered gold nanostructures. , 2014, Nanoscale.

[35]  G. Xu,et al.  Gold nanorod enhanced two-photon excitation fluorescence of photosensitizers for two-photon imaging and photodynamic therapy. , 2014, ACS applied materials & interfaces.

[36]  X. Fang,et al.  Gold nanorod-embedded electrospun fibrous membrane as a photothermal therapy platform. , 2014, ACS applied materials & interfaces.

[37]  B. Kong,et al.  Tungsten Oxide Nanorods: An Efficient Nanoplatform for Tumor CT Imaging and Photothermal Therapy , 2014, Scientific Reports.

[38]  Jian Ji,et al.  Mussel-inspired polydopamine: a biocompatible and ultrastable coating for nanoparticles in vivo. , 2013, ACS nano.

[39]  S. Achilefu,et al.  Multifunctional Gold Nanostar Conjugates for Tumor Imaging and Combined Photothermal and Chemo-therapy , 2013, Theranostics.

[40]  Jordi Llop,et al.  Biodistribution of different sized nanoparticles assessed by positron emission tomography: a general strategy for direct activation of metal oxide particles. , 2013, ACS nano.

[41]  Lehui Lu,et al.  Dopamine‐Melanin Colloidal Nanospheres: An Efficient Near‐Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy , 2013, Advanced materials.

[42]  Linfeng Zheng,et al.  Facile hydrothermal synthesis and surface functionalization of polyethyleneimine-coated iron oxide nanoparticles for biomedical applications. , 2013, ACS applied materials & interfaces.

[43]  Xin Cai,et al.  Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment. , 2013, ACS nano.

[44]  Yunpeng Huang,et al.  Multifunctional dendrimer-entrapped gold nanoparticles for dual mode CT/MR imaging applications. , 2013, Biomaterials.

[45]  V. Ball,et al.  Kinetics of polydopamine film deposition as a function of pH and dopamine concentration: insights in the polydopamine deposition mechanism. , 2012, Journal of colloid and interface science.

[46]  J. Fei,et al.  Hypocrellin-loaded gold nanocages with high two-photon efficiency for photothermal/photodynamic cancer therapy in vitro. , 2012, ACS nano.

[47]  Tuan Vo-Dinh,et al.  TAT peptide-functionalized gold nanostars: enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance. , 2012, Journal of the American Chemical Society.

[48]  Younan Xia,et al.  Evaluating the pharmacokinetics and in vivo cancer targeting capability of Au nanocages by positron emission tomography imaging. , 2012, ACS nano.

[49]  Mingwu Shen,et al.  PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography. , 2012, Biomaterials.

[50]  Ki Young Choi,et al.  Theranostic nanoplatforms for simultaneous cancer imaging and therapy: current approaches and future perspectives. , 2012, Nanoscale.

[51]  Rujia Zou,et al.  Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. , 2011, ACS nano.

[52]  Younan Xia,et al.  Gold nanocages: from synthesis to theranostic applications. , 2011, Accounts of chemical research.

[53]  J. Gracio,et al.  Dopamine-melanin film deposition depends on the used oxidant and buffer solution. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[54]  Klaas Nicolay,et al.  Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents. , 2010, Biomaterials.

[55]  Kai Yang,et al.  Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. , 2010, Nano letters.

[56]  Raoul Kopelman,et al.  Targeted gold nanoparticles enable molecular CT imaging of cancer. , 2008, Nano letters.

[57]  J. Richie,et al.  Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. , 2006, Proceedings of the National Academy of Sciences of the United States of America.