A practical approach to OCT based classification of Diabetic Macular Edema

This paper addresses the problem of automatic classification of OCT images for identification of patients with DME versus normal subjects. In this paper a relativity simple and practical approach is proposed to exploit the information in OCT images for a robust classification of Diabetic Macular Edema (DME) using coherent tensors. From the retinal OCT scan top and bottom layers are extracted to find thickness profile. Cyst spaces are also segmented out from the normal and DME images. The features extracted from thickness profile and cyst are tested on Duke Dataset having 55 diseased and 53 normal OCT scans. Results reveal that SVM with Leave-one-Out gives the maximum accuracy of 79.65% with 7.6 standard deviation. However, experiments reveal that for the identification of DME, nearly same accuracy of 78.7% can be achieved by using a simple threshold which can be calculated using thickness variation of OCT layers. Moreover a comparison of the proposed algorithm on a standard dataset with other recently published work shows that our method gives the best classification performance.

[1]  Bartosz L. Sikorski,et al.  The Diagnostic Function of OCT in Diabetic Maculopathy , 2013, Mediators of inflammation.

[2]  Desislava Koleva-Georgieva,et al.  Optical Coherence Tomography Findings in Diabetic Macular Edema , 2012 .

[3]  Peter K Kaiser,et al.  Optical coherence tomography imaging of macular oedema , 2014, British Journal of Ophthalmology.

[4]  C. Keith Retinal cysts and retinoschisis. , 1966, The British journal of ophthalmology.

[5]  Sina Farsiu,et al.  Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images. , 2014, Biomedical optics express.

[6]  Wolfgang Drexler,et al.  State-of-the-art retinal optical coherence tomography , 2008, Progress in Retinal and Eye Research.

[7]  J Cunha-Vaz,et al.  Diabetic Macular Edema , 1998 .

[8]  Taimur Hassan,et al.  Review of OCT and fundus images for detection of Macular Edema , 2015, 2015 IEEE International Conference on Imaging Systems and Techniques (IST).

[9]  Chi-Chun Lai,et al.  Current Treatments of Diabetic Macular Edema , 2011 .

[10]  D. Sobieraj,et al.  Improving Diabetic Retinopathy Screening Through a Statewide Telemedicine Program at a Large Federally Qualified Health Center , 2011, Journal of health care for the poor and underserved.

[11]  Bram van Ginneken,et al.  Automated age-related macular degeneration classification in OCT using unsupervised feature learning , 2015, Medical Imaging.

[12]  Adeel M. Syed,et al.  Automated segmentation of subretinal layers for the detection of macular edema. , 2016, Applied optics.

[13]  F. Mériaudeau,et al.  Classification of SD-OCT Volumes Using Local Binary Patterns: Experimental Validation for DME Detection , 2016, Journal of ophthalmology.

[14]  Sina Farsiu,et al.  Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema. , 2015, Biomedical optics express.

[15]  J. Bigun,et al.  Optimal Orientation Detection of Linear Symmetry , 1987, ICCV 1987.

[16]  M. Khairallah,et al.  Diabetic Macular Edema. An OCT-Based Classification , 2008 .

[17]  Taimur Hassan,et al.  Structure tensor based automated detection of macular edema and central serous retinopathy using optical coherence tomography images. , 2016, Journal of the Optical Society of America. A, Optics, image science, and vision.