A Micropower Electrocardiogram Amplifier

We introduce an electrocardiogram (EKG) preamplifier with a power consumption of 2.8 muW, 8.1 muVrms input-referred noise, and a common-mode rejection ratio of 90 dB. Compared to previously reported work, this amplifier represents a significant reduction in power with little compromise in signal quality. The improvement in performance may be attributed to many optimizations throughout the design including the use of subthreshold transistor operation to improve noise efficiency, gain-setting capacitors versus resistors, half-rail operation wherever possible, optimal power allocations among amplifier blocks, and the sizing of devices to improve matching and reduce noise. We envision that the micropower amplifier can be used as part of a wireless EKG monitoring system powered by rectified radio-frequency energy or other forms of energy harvesting like body vibration and body heat.

[1]  Alan B. Grebene,et al.  Analog Integrated Circuit Design , 1978 .

[2]  Kristofer S. J. Pister,et al.  An ultra–low power ADC for distributed sensor networks , 2002 .

[3]  C. Mead,et al.  White noise in MOS transistors and resistors , 1993, IEEE Circuits and Devices Magazine.

[4]  David A. Johns,et al.  Analog Integrated Circuit Design , 1996 .

[5]  R. R. Harrison,et al.  A low-power low-noise CMOS amplifier for neural recording applications , 2003, IEEE J. Solid State Circuits.

[6]  Soumyajit Mandal,et al.  Low-Power CMOS Rectifier Design for RFID Applications , 2007, IEEE Transactions on Circuits and Systems I: Regular Papers.

[7]  Y. Nemirovsky,et al.  1/f noise in CMOS transistors for analog applications , 2001 .

[8]  Robert G. Meyer,et al.  Analysis and Design of Analog Integrated Circuits , 1993 .

[9]  Gu-Yeon Wei,et al.  A portable, low-power, wireless two-lead EKG system , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[10]  Tobi Delbrück,et al.  Adaptive photoreceptor with wide dynamic range , 1994, Proceedings of IEEE International Symposium on Circuits and Systems - ISCAS '94.

[11]  Cedric Assambo,et al.  An improved micro-power pre-amplifier for dry-electrode ECG recording , 2007 .

[12]  Ying Bai,et al.  An ultra-wearable, wireless, low power ECG monitoring system , 2006, 2006 IEEE Biomedical Circuits and Systems Conference.

[13]  SarpeshkarRahul,et al.  A Low-Power Wide-Linear-Range Transconductance Amplifier , 1997 .

[14]  Rahul Sarpeshkar,et al.  An ultra-low-power programmable analog bionic ear processor , 2005, IEEE Transactions on Biomedical Engineering.

[15]  D. Pugh,et al.  C.M.R.R. analysis of the 3-op-amp instrumentation amplifier , 1977 .

[16]  Rahul Sarpeshkar,et al.  A Low-Power Wide-Linear-Range Transconductance Amplifier , 1997 .

[17]  A.-T. Avestruz,et al.  A 2 $\mu\hbox{W}$ 100 nV/rtHz Chopper-Stabilized Instrumentation Amplifier for Chronic Measurement of Neural Field Potentials , 2007, IEEE Journal of Solid-State Circuits.

[18]  Refet Firat Yazicioglu,et al.  A 60/spl mu/W 60 nV/Hz Readout Front-End for Portable Biopotential Acquisition Systems , 2006, 2006 IEEE International Solid State Circuits Conference - Digest of Technical Papers.

[19]  A. Hastings The Art of Analog Layout , 2000 .

[20]  Rahul Sarpeshkar,et al.  An Energy-Efficient Micropower Neural Recording Amplifier , 2007, IEEE Transactions on Biomedical Circuits and Systems.

[21]  Rui Escadas Martins,et al.  A CMOS IC for portable EEG acquisition systems , 1998, IEEE Trans. Instrum. Meas..

[22]  Martin J. Burke,et al.  A micropower dry-electrode ECG preamplifier , 2000, IEEE Transactions on Biomedical Engineering.

[23]  John G. Webster,et al.  Reductionl of Interference Due to Common Mode Voltage in Biopotential Amplifiers , 1983, IEEE Transactions on Biomedical Engineering.

[24]  Reid R. Harrison,et al.  A low-power, low-noise CMOS amplifier for neural recording applications , 2002, 2002 IEEE International Symposium on Circuits and Systems. Proceedings (Cat. No.02CH37353).

[25]  Scott K. Arfin,et al.  Fast startup CMOS current references , 2006, 2006 IEEE International Symposium on Circuits and Systems.

[26]  Rahul Sarpeshkar,et al.  A Bio-Inspired Ultra-Energy-Efficient Analog-to-Digital Converter for Biomedical Applications , 2006, IEEE Transactions on Circuits and Systems I: Regular Papers.

[27]  P. K. Chan,et al.  A CMOS analog front-end IC for portable EEG/ECG monitoring applications , 2005, IEEE Transactions on Circuits and Systems I: Regular Papers.