11β-Hydroxysteroid dehydrogenase 1 contributes to the pro-inflammatory response of keratinocytes.

[1]  Lianne Abrahams,et al.  11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. , 2013, The Journal of clinical investigation.

[2]  H. Murota,et al.  Expression profiles of cortisol‐inactivating enzyme, 11β‐hydroxysteroid dehydrogenase‐2, in human epidermal tumors and its role in keratinocyte proliferation , 2013, Experimental dermatology.

[3]  Blazej Zbytek,et al.  Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system. , 2012, Advances in anatomy, embryology, and cell biology.

[4]  T. Brunner,et al.  Local glucocorticoid production in the mouse lung is induced by immune cell stimulation , 2012, Allergy.

[5]  J. Seckl,et al.  Explorer 11-Hydroxysteroid Dehydrogenase Type 1 , But Not Type 2 , Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice , 2011 .

[6]  A. Kimura,et al.  11β-Hydroxysteroid Dehydrogenase-1 Is a Novel Regulator of Skin Homeostasis and a Candidate Target for Promoting Tissue Repair , 2011, PloS one.

[7]  N. Cirillo,et al.  Keratinocytes synthesize and activate cortisol , 2011, Journal of cellular biochemistry.

[8]  O. Stojadinović,et al.  Cortisol Synthesis in Epidermis Is Induced by IL-1 and Tissue Injury* , 2011, The Journal of Biological Chemistry.

[9]  T. Brunner,et al.  TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis , 2010, The Journal of experimental medicine.

[10]  K. Nakao,et al.  Glucocorticoid reamplification within cells intensifies NF-kappaB and MAPK signaling and reinforces inflammation in activated preadipocytes. , 2010, American journal of physiology. Endocrinology and metabolism.

[11]  M. Cooper,et al.  11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation. , 2009, The Journal of clinical endocrinology and metabolism.

[12]  M. Hori,et al.  Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure , 2009, Journal of hypertension.

[13]  P. Elias,et al.  Skin as an endocrine organ: implications for its function. , 2008, Drug discovery today. Disease mechanisms.

[14]  H. Reichardt,et al.  Glucocorticoids exert opposing effects on macrophage function dependent on their concentration , 2007, Immunology.

[15]  Johan Auwerx,et al.  LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease , 2007, Proceedings of the National Academy of Sciences.

[16]  S. Alran,et al.  Dehydroepiandrosterone 7α-hydroxylation in human tissues: Possible interference with type 1 11β-hydroxysteroid dehydrogenase-mediated processes , 2007, The Journal of Steroid Biochemistry and Molecular Biology.

[17]  K. Nakao,et al.  Augmentation of 11β‐hydroxysteroid dehydrogenase type 1 in LPS‐activated J774.1 macrophages – Role of 11β‐HSD1 in pro‐inflammatory properties in macrophages , 2007, FEBS letters.

[18]  R. Paus,et al.  Differential expression of HPA axis homolog in the skin , 2007, Molecular and Cellular Endocrinology.

[19]  Olivera Stojadinovic,et al.  Novel Genomic Effects of Glucocorticoids in Epidermal Keratinocytes , 2006, Journal of Biological Chemistry.

[20]  T. Brunner,et al.  The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine , 2006, The Journal of experimental medicine.

[21]  A. Slominski,et al.  Cultured human dermal fibroblasts do produce cortisol. , 2006, The Journal of investigative dermatology.

[22]  R. Paus,et al.  Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  A. Slominski,et al.  CRH stimulates POMC activity and corticosterone production in dermal fibroblasts , 2005, Journal of Neuroimmunology.

[24]  A. Slominski,et al.  CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. , 2005, American journal of physiology. Endocrinology and metabolism.

[25]  J. Seckl 11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action. , 2004, Current opinion in pharmacology.

[26]  J. Marcos,et al.  A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. , 2004, European journal of biochemistry.

[27]  J. Cidlowski,et al.  Mechanisms of glucocorticoid receptor signaling during inflammation , 2004, Mechanisms of Ageing and Development.

[28]  Jeremy W Tomlinson,et al.  11 (cid:1) -Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid Response , 2004 .

[29]  A. Munck,et al.  Glucocorticoid regulation of the inflammatory response to injury , 2004, Acta anaesthesiologica Scandinavica.

[30]  M. Young,et al.  Cardiac steroidogenesis in the normal and failing heart. , 2001, The Journal of clinical endocrinology and metabolism.

[31]  G. Caramori,et al.  Cross‐talk between pro‐inflammatory transcription factors and glucocorticoids , 2001, Immunology and cell biology.

[32]  E. Sternberg,et al.  Neuroendocrine regulation of autoimmune/inflammatory disease. , 2001, The Journal of endocrinology.

[33]  P. White,et al.  Steroidogenic enzyme gene expression in the human heart. , 2000, The Journal of clinical endocrinology and metabolism.

[34]  C. Gomez-Sanchez,et al.  Active steroidogenesis in the normal rat skin. , 2000, Biochimica et biophysica acta.

[35]  R. Sapolsky,et al.  How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. , 2000, Endocrine reviews.

[36]  C. Gomez-Sanchez,et al.  Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells , 1999, FEBS letters.

[37]  F. Dhabhar,et al.  The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions , 1997, Brain Research Reviews.

[38]  T. Wilckens Glucocorticoids and immune function: physiological relevance and pathogenic potential of hormonal dysfunction. , 1995, Trends in pharmacological sciences.

[39]  E. Walker,et al.  Localization, age- and site-dependent expression, and regulation of 11β-hydroxysteroid dehydrogenase type 1 in skin. , 2011, The Journal of investigative dermatology.