Cardiac modeling using active appearance models and morphological operators

We present an approach for fast reconstructing of cardiac myocardium and blood masses of a patient's heart from morphological image data, acquired either MRI or CT, in order to estimate numerically the spread of electrical excitation in the patient's atria and ventricles. The approach can be divided into two main steps. During the first step the ventricular and atrial blood masses are extracted employing Active Appearance Models (AAM). The left and right ventricular blood masses are segmented automatically after providing the positions of the apex cordis and the base of the heart. Because of the complex geometry of the atria the segmentation process of the atrial blood masses requires more information as the ventricular blood mass segmentation process of the ventricles. We divided, for this reason, the left and right atrium into three divisions of appearance. This proved sufficient for the 2D AAM model to extract the target blood masses. The base of the heart, the left upper and left lower pulmonary vein from its first up to its last appearance in the image stack, and the right upper and lower pulmonary vein have to be marked. After separating the volume data into these divisions the 2D AAM search procedure extracts the blood masses which are the main input for the second and last step in the myocardium extraction pipeline. This step uses morphologically-based operations in order to extract the ventricular and atrial myocardium either directly by detecting the myocardium in the volume block or by reconstructing the myocardium using mean model information, in case the algorithm fails to detect the myocardium.

[1]  F. Morady Radio-frequency ablation as treatment for cardiac arrhythmias. , 1999, The New England journal of medicine.

[2]  G. Huiskamp,et al.  The depolarization sequence of the human heart surface computed from measured body surface potentials , 1988, IEEE Transactions on Biomedical Engineering.

[3]  Bernhard Pfeifer,et al.  Atrial myocardium model extraction , 2004, Medical Imaging: Image-Guided Procedures.

[4]  Timothy F. Cootes,et al.  Interpreting face images using active appearance models , 1998, Proceedings Third IEEE International Conference on Automatic Face and Gesture Recognition.

[5]  F Greensite The mathematical basis for imaging cardia electrical function. , 1994, Critical reviews in biomedical engineering.

[6]  Timothy F. Cootes,et al.  Modelling Object Appearance using The Grey-Level Surface , 1994, BMVC.

[7]  Timothy F. Cootes,et al.  Active Appearance Models , 2001, IEEE Trans. Pattern Anal. Mach. Intell..

[8]  Robert Modre,et al.  An iterative algorithm for myocardial activation time imaging , 2001, Comput. Methods Programs Biomed..

[9]  C. Tai,et al.  Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation. , 1999, Circulation.

[10]  R Modre-Osprian,et al.  Atrial and Ventricular Myocardium Extraction Using Model-based Techniques , 2006, Methods of Information in Medicine.

[11]  J Clémenty,et al.  Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. , 1998, The New England journal of medicine.

[12]  Timothy F. Cootes,et al.  Automatic tracking, coding and reconstruction of human faces, using flexible appearance models , 1994 .

[13]  Robert Modre,et al.  Model-based imaging of cardiac electrical excitation in humans , 2002, IEEE Transactions on Medical Imaging.

[14]  Ian Craw,et al.  Parameterising Images for Recognition and Reconstruction , 1991 .

[15]  Edward R. Dougherty,et al.  Hands-on Morphological Image Processing , 2003 .