Personal neoantigen cancer vaccines

Neoantigen-based cancer vaccines designed to target the unique immunogenic mutations arising in each patient’s tumor are breathing new life into a struggling approach. Data continue to demonstrate the importance of neoantigens in immune control of cancer. Despite manufacturing complexity, outstanding questions and desired further improvements, neoantigen vaccines are currently undergoing clinical evaluation.

[1]  T. Graham.  Faculty Opinions recommendation of Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival. , 2016 .

[2]  K. Cibulskis,et al.  Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. , 2014, Blood.

[3]  S. Rosenberg,et al.  Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer , 2014, Science.

[4]  Scott D. Brown,et al.  Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival , 2014, Genome research.

[5]  D. Douek,et al.  PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors. , 2014, The Journal of clinical investigation.

[6]  N. Hacohen,et al.  HLA-Binding Properties of Tumor Neoepitopes in Humans , 2014, Cancer Immunology Research.

[7]  R. Holt,et al.  Surveillance of the Tumor Mutanome by T Cells during Progression from Primary to Recurrent Ovarian Cancer , 2013, Clinical Cancer Research.

[8]  M. Stratton,et al.  Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  D. Neuberg,et al.  Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells. , 2013, The Journal of clinical investigation.

[10]  Jimmy Lin,et al.  Mining Exomic Sequencing Data to Identify Mutated Antigens Recognized by Adoptively Transferred Tumor-reactive T cells , 2013, Nature Medicine.

[11]  N. Hacohen,et al.  Cancer Immunology at the Crossroads : Functional Genomics Getting Personal with Neoantigen-Based Therapeutic Cancer Vaccines , 2013 .

[12]  Pia Kvistborg,et al.  The cancer antigenome , 2012, The EMBO journal.