A case of ovarian metastasis of gall bladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature

The ovary is a relatively frequent site of metastases from malignant neoplasia arising elsewhere in the body, the majority of these originating from the gastrointestinal tract. The best-known tumor of this type is signet ring cell adenocarcinoma (Krukenberg tumor) of gastric origin and large bowel. The gall bladder and bile ducts are extremely rare sources of these metastases. The casuistic describes a female patient, presented with pelvic mass and jaundice. While clinical and imaging results suggested a primary ovarian carcinoma with incidental cholelithiasis and choledocholithiasis, the final diagnosis was obtained on the basis of histopathologic findings of resected specimen.

[1]  Brigitte M. Ronnett,et al.  Primary and Metastatic Mucinous Adenocarcinomas in the Ovaries: Incidence in Routine Practice With a New Approach to Improve Intraoperative Diagnosis , 2003, The American journal of surgical pathology.

[2]  R. Young,et al.  The Distinction Between Primary and Metastatic Mucinous Carcinomas of the Ovary: Gross and Histologic Findings in 50 Cases , 2003, The American journal of surgical pathology.

[3]  M. Bajka,et al.  [Krukenberg syndrome in metastatic gallbladder adenocarcinoma with unknown primary tumor]. , 1999, Praxis.

[4]  B. Behmaram,et al.  Primary biliary carcinoma with metastasis to the ovary. , 1992, Gynecologic Oncology.

[5]  K. Hušek [Secondary adenocarcinoma of the ovary and problems in diagnosis]. , 1992, Ceskoslovenska patologie.

[6]  R. Scully,et al.  Metastatic tumors in the ovary: a problem-oriented approach and review of the recent literature. , 1991, Seminars in diagnostic pathology.

[7]  R. Yazigi,et al.  Ovarian involvement in extragenital cancer. , 1989, Gynecologic oncology.

[8]  S. Martin,et al.  Malignant Melanoma Metastatic to the Ovary , 1987, The American journal of surgical pathology.

[9]  N. Dubin,et al.  Secondary Ovarian Carcinoma: A Clinical and Pathological Evaluation , 1987, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[10]  R. Scully,et al.  Ovarian metastases from cancer of the lung: problems in interpretation--a report of seven cases. , 1985, Gynecologic oncology.

[11]  M. Mazur,et al.  Metastases to the female genital tract: Analysis of 325 cases , 1984, Cancer.

[12]  T. Ulbright,et al.  Secondary ovarian neoplasia. A clinicopathologic study of 35 cases , 1984, Cancer.

[13]  D. Dennis,et al.  Laparotomy for „ovarian tumors”︁ in unsuspected carcinoma of the colon , 1968, Cancer.

[14]  Harald Johansson Clinical Aspects of Metastatic Ovarian Cancer of Extragenital Origin , 1960, Acta obstetricia et gynecologica Scandinavica.

[15]  A. Ayhan,et al.  Ovarian metastasis of primary biliary and gallbladder carcinomas. , 2001, European journal of gynaecological oncology.

[16]  W. Hamm,et al.  [Isolated ovarian metastasis of primary gallbladder carcinoma with estrogen and androgen production]. , 1996, Zentralblatt für Gynäkologie.