Dissecting abdominal aortic aneurysm in Ang II-infused mice : the importance of imaging

Introduction. Since the initial publication in 2000, Angiotensin II-infused mice have become the model of choice to study abdominal aortic aneurysm in a pre-clinical setting. We recently used phase contrast X-ray based computed tomography to challenge the existing paradigm and demonstrated that these animals develop an apparent luminal dilatation and an intramural hematoma, both related to mural ruptures in the tunica media in the vicinity of suprarenal side branches, providing evidence that the main lesion is rather a mere dissection without previous

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