Survival of a patient with pancytopenia and disseminated coagulation associated with miliary tuberculosis.

A 56-year-old man with histologically and bacteriologically proved disseminated tuberculosis in association with pancytopenia responded to antituberculosis chemotherapy with bacteriologic cure of his tuberculosis and concomitant resolution of the pancytopenia. This association has been generally believed to have a nearly 100 percent mortality. In addition, the patient developed laboratory evidence of disseminated intravascular coagulation (DIC). The single and simultaneous occurrence of these two hematologic abnormalities is extremely rare. A number of factors possibly relating to the development of pancytopenia and DIC in conjunction with miliary tuberculosis are briefly discussed.

[1]  L. Hudson,et al.  Miliary tuberculosis and adult respiratory distress syndrome. , 1976, Annals of internal medicine.

[2]  H. Roberts,et al.  Letter: Isoniazid and disseminated intravascular coagulation. , 1976, Annals of Internal Medicine.

[3]  E. Harman,et al.  Miliary tuberculosis presenting as acute respiratory failure: treatment by membrane oxygenator and ventricle pump. , 1975, Chest.

[4]  R. Blowers,et al.  Tuberculosis and Blood Disorders , 1973, British journal of haematology.

[5]  W. Crosby,et al.  Disseminated intravascular coagulation in miliary tuberculosis. , 1972, Archives of internal medicine.

[6]  P. Mangion,et al.  Disseminated Tuberculosis Complicated by Pancytopenia , 1971, Proceedings of the Royal Society of Medicine.

[7]  D. Deykin.  The clinical challenge of disseminated intravascular coagulation. , 1970, The New England journal of medicine.

[8]  R. Walker,et al.  The significance of hematologic abnormalities in patients with tuberculosis. , 1970, Archives of internal medicine.

[9]  H. Kingdon,et al.  Consumption coagulopathy in miliary tuberculosis. , 1969, Annals of internal medicine.

[10]  M. G. Nelson,et al.  Disseminated tuberculosis with associated haematological disorders , 1969 .

[11]  W. Cooper.  Pancytopenia associated with disseminated tuberculosis. , 1959, Annals of internal medicine.

[12]  W. E. Medd,et al.  Tuberculous miliary necrosis with pancytopenia. , 1955, The Quarterly journal of medicine.

[13]  J. Paulley.  Blood Changes in Tuberculosis , 1954 .

[14]  J. Fountain.  Blood Changes Associated with Disseminated Tuberculosis , 1954 .

[15]  F. edridge-green.  THE BOARD OF TRADE AND DR. EDRIDGE-GREEN , 1915 .