Salivary gland tumors: A 20-year review of clinical diagnostic accuracy at a single center

Obtaining reliable pre-operative diagnosis is crucial in planning treatment for patients with salivary gland tumors. The purpose of this study was to evaluate the accuracy of pre-operative clinical diagnosis of salivary gland tumors managed at a single tertiary university hospital over a period of 20 years. A retrospective analysis of the period between 1992 and 2011 was carried out to review the cases of patients with salivary gland tumors. A total of 101 patients were enrolled and general data were described. Clinical diagnosis was compared with the final pathological diagnosis to reveal the clinical diagnostic accuracy. Of the parotid and submandibular gland tumors, 86 and 67% were benign, respectively. The clinical diagnostic accuracies for diagnosis of parotid tumors as benign or malignant were 100 and 57%, respectively. The clinical diagnostic accuracies for diagnosis of submandibular tumors as benign or malignant were 67%. Therefore, the overall clinical judgment of benign and malignant tumors in the submandibular gland is unreliable. The accuracy for a parotid tumor to be clinically interpreted as benign was 100%. While it is difficult to draw any conclusion for non-parotid gland tumors, surgical intervention should be recommended in patients with parotid tumors clinically suspected to be malignant, and all submandibular, sublingual and minor salivary gland tumors.

[1]  Hui Li,et al.  Predictive index for lymph node management of major salivary gland cancer , 2012, The Laryngoscope.

[2]  Konstantinos Vahtsevanos,et al.  Fine-needle aspiration cytology of salivary gland tumours: a 10-year retrospective analysis , 2012, Oral and Maxillofacial Surgery.

[3]  I. Tateya,et al.  [A study of salivary gland aspiration cytology reporting: guideline validity]. , 2011, Nihon Jibiinkoka Gakkai kaiho.

[4]  S. Martin,et al.  US-guided fine-needle aspiration of major salivary gland masses and adjacent lymph nodes: accuracy and impact on clinical decision making. , 2011, Radiology.

[5]  J. Serpell,et al.  Preoperative fine needle cytology and imaging facilitates the management of submandibular salivary gland lesions , 2009, ANZ journal of surgery.

[6]  K. Maiti,et al.  Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry. , 2010, Journal of the Indian Medical Association.

[7]  B. Vicandi,et al.  Role of fine needle aspiration cytology in the diagnosis and management of Warthin’s tumour of the salivary glands , 2009, Cytopathology : official journal of the British Society for Clinical Cytology.

[8]  C. Godballe,et al.  Value of fine‐needle aspiration biopsy of salivary gland lesions , 2009, Head & neck.

[9]  J. L. St Guily,et al.  Value of the cytological diagnosis in the treatment of parotid tumors , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[10]  J. Ko,et al.  Analysis of fine-needle aspiration cytology of the salivary gland. , 2008, Journal of the Formosan Medical Association = Taiwan yi zhi.

[11]  J. Choi,et al.  Role of 18F-FDG PET/CT in Management of High-Grade Salivary Gland Malignancies , 2007, Journal of Nuclear Medicine.

[12]  K. Ogawa,et al.  Role of Salivary Gland Scintigraphy With Tc-99m Pertechnetate in Determining Treatment of Solitary Parotid Gland Tumors: A Retrospective Study , 2007, Clinical nuclear medicine.

[13]  N. K. Kavabata,et al.  [Fine needle aspiration in salivary gland tumors: specificity and sensitivity]. , 2007, Revista da Associacao Medica Brasileira.

[14]  C. Martin,et al.  Morphologie IRM des tuméfactions de la glande parotide. Corrélations histopathologiques , 2007 .

[15]  J. Dumollard,et al.  [Parotid gland masses: diagnostic value of MR imaging with histopathologic correlations]. , 2007, Morphologie : bulletin de l'Association des anatomistes.

[16]  F. Salaffi,et al.  [Usefulness of ultrasonography and color Doppler sonography in the diagnosis of major salivary gland diseases]. , 2011, Reumatismo.

[17]  M. Quraishi,et al.  A comparison of the incidence of facial palsy following parotidectomy performed by ENT and non-ENT surgeons , 2006, The Journal of Laryngology & Otology.

[18]  T. Nakashima,et al.  Comparison of preoperative fine-needle aspiration cytology diagnosis and histopathological diagnosis of salivary gland tumors. , 2006, The Kurume medical journal.

[19]  O. Guntinas-Lichius,et al.  Risk of facial palsy and severe Frey's syndrome after conservative parotidectomy for benign disease: analysis of 610 operations , 2006, Acta oto-laryngologica.

[20]  T. Higuchi,et al.  Positron emission tomographic imaging with11C-choline in differential diagnosis of head and neck tumors: comparison with18F-FDG PET , 2004, Annals of nuclear medicine.

[21]  J. Shah,et al.  Fine-needle aspiration biopsy of salivary gland lesions in a selected patient population. , 2004, Archives of otolaryngology--head & neck surgery.

[22]  K. Nagao,et al.  Malignant parotid gland tumors and facial nerve paralysis , 1984, Archives of oto-rhino-laryngology.

[23]  E. Janska,et al.  Fine needle aspiration biopsy in a diagnostic workup algorithm of salivary gland tumors. , 2003, Neoplasma (Bratislava).

[24]  E. Yumoto,et al.  [Clinical significance of fine-needle aspiration biopsy in major salivary gland tumors]. , 2002, Nihon Jibiinkoka Gakkai kaiho.

[25]  J. Jacobs,et al.  Predictors of nodal metastasis in salivary gland cancer , 2002, Journal of surgical oncology.

[26]  G. Fillola,et al.  [Value of of fine-needle aspiration cytology and MRI in parotid gland masses]. , 2002, Revue de laryngologie - otologie - rhinologie.

[27]  A. Afify,et al.  Salivary Gland Fine Needle Aspiration Using the ThinPrep® Technique , 2001, Acta Cytologica.

[28]  T. Ichikawa,et al.  Various imaging modalities for the detection of salivary gland lesions: The advantages of 201Tl SPET , 2000, Nuclear medicine communications.

[29]  K. Mackenzie,et al.  Fine‐needle aspiration cytology of salivary gland: A review of 341 cases , 2000, Diagnostic cytopathology.

[30]  J. Medina.  Neck dissection in the treatment of cancer of major salivary glands. , 1998, Otolaryngologic clinics of North America.

[31]  H. Ishinaga,et al.  [Neck Dissection for salivary gland carcinoma]. , 1998, Nihon Jibiinkoka Gakkai kaiho.

[32]  N. Gritzmann,et al.  [The value of sonography in salivary gland tumors]. , 1989, HNO.

[33]  R. Chisin,et al.  The clinical value of quantitative dynamic scintigraphy in salivary gland disorders. , 1988, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

[34]  P. Lundquist,et al.  Salivary calculi and chronic sialoadenitis of the submandibular gland: a radiographic and histologic study. , 1984, Oral surgery, oral medicine, and oral pathology.

[35]  R. R. Smith,et al.  Radionuclide salivary imaging usefulness in a private otolaryngology practice. , 1981, Archives of otolaryngology.

[36]  E. Röttinger,et al.  The diagnostic value of sialography and scintigraphy in salivary gland diseases. , 1976, The British journal of radiology.

[37]  C. Eneroth.  Facial nerve paralysis. A criterion of malignancy in parotid tumors. , 1972, Archives of otolaryngology.